Horizon Pharma plc Contracts & Agreements

Amendment No. 10 to the License Agreement, dated May 22, 2023, by and among F. Hoffmann-La Roche Ltd, Hoffman-La Roche Inc. and Horizon Therapeutics Ireland DAC (as successor in... (Filed With SEC on August 8, 2023)

Transaction Agreement, dated as of December 11, 2022, by and among Amgen Inc., Pillartree Limited and Horizon Therapeutics plc (Filed With SEC on December 12, 2022)

Appendix 3 to the Rule 2.7 Announcement, dated as of December 12, 2022 (Conditions Appendix) (Filed With SEC on December 12, 2022)

Executive Employment Agreement, effective as of November 1, 2021, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Aaron Cox (Filed With SEC on August 3, 2022)

Executive Employment and Transition Agreement, dated May 11, 2022, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Paul W. Hoelscher (Filed With SEC on August 3, 2022)

Executive Employment Agreement, effective as of May 15, 2022, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Jacopo Leonardi (Filed With SEC on August 3, 2022)

Amendment No. 4 to Commercial Supply Agreement, dated May 31, 2022, by and between AGC Biologics A/S (formerly known as CMC Biologics A/S) and Horizon Therapeutics Ireland DAC (Filed With SEC on August 3, 2022)

Horizon Therapeutics Public Limited Company Non-Employee Director Compensation Policy, as amended (Filed With SEC on May 4, 2022)

Horizon Therapeutics Public Limited Company Non-Employee Director Compensation Policy, as amended (Filed With SEC on March 1, 2022)

Horizon Therapeutics Public Limited Company Amended and Restated 2020 Equity Incentive Plan, as amended, and 2020 Restricted Stock Unit Award Sub-Plan and Form of Option... (Filed With SEC on March 1, 2022)

Horizon Therapeutics Public Limited Company Amended and Restated 2018 Equity Incentive Plan (assumed from Viela Bio, Inc.), as amended, and 2018 Restricted Stock Unit Award... (Filed With SEC on March 1, 2022)

Master Manufacturing Services Agreement, dated October 15, 2018, by and between Patheon Pharmaceuticals Inc. and Horizon Medicines LLC (Filed With SEC on March 1, 2022)

Release and Waiver of Claims of Brian Beeler, dated as of January 6, 2022 (Filed With SEC on March 1, 2022)

Release and Waiver of Claims of Barry Moze, dated as of January 10, 2022 (Filed With SEC on March 1, 2022)

Executive Employment Agreement, effective as of February 28, 2022, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Sean M. Clayton (Filed With SEC on March 1, 2022)

Horizon Therapeutics Public Limited Company Amended and Restated 2020 Equity Incentive Plan and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted... (Filed With SEC on November 3, 2021)

Horizon Therapeutics Public Limited Company Amended and Restated 2018 Equity Incentive Plan (assumed from Viela Bio, Inc.) and Form of RSU Award Grant Notice and Form of Award... (Filed With SEC on November 3, 2021)

Horizon Therapeutics Public Limited Company 2014 Non-Employee Equity Plan, as amended, and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted Stock... (Filed With SEC on November 3, 2021)

Third Supplemental Indenture, dated March 15, 2021, by and between Viela Bio, Inc. and U.S. Bank National Association (Filed With SEC on May 5, 2021)

Executive Employment Agreement, effective as of March 15, 2021, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Elizabeth H.Z. Thompson (Filed With SEC on May 5, 2021)

License Agreement, dated April 16, 1999, by and among Saul Brusilow, M.D., Brusilow Enterprises, Inc. and Horizon Therapeutics, LLC (as successor in interest to Medicis... (Filed With SEC on February 24, 2021)

Settlement Agreement and First Amendment to License Agreement, dated August 21, 2007, by and among Saul Brusilow, M.D., Brusilow Enterprises, Inc., and Horizon Therapeutics, LLC... (Filed With SEC on February 24, 2021)

License Agreement, dated August 12, 1998, by and among Mountain View Pharmaceuticals, Inc., Duke University and Horizon Therapeutics Ireland DAC (as successor in interest to... (Filed With SEC on February 24, 2021)

Agreement and Plan of Merger, dated January 31, 2021, by and among Horizon Therapeutics USA, Inc., Teiripic Merger Sub, Inc., Viela Bio, Inc. and solely for purposes of Sections... (Filed With SEC on February 1, 2021)

Amendment No. 3 to Commercial Supply Agreement, dated July 30, 2020, by and between AGC Biologics A/S (formerly known as CMC Biologics A/S) and Horizon Therapeutics Ireland DAC (Filed With SEC on November 2, 2020)

Development and Manufacturing Services Agreement, dated June 10, 2015, by and between AGC Biologics A/S (formerly known as CMC Biologics A/S) and Horizon Therapeutics Ireland DAC... (Filed With SEC on November 2, 2020)

Incremental Amendment and Lender Joinder Agreement, dated August 17, 2020, by and among JP Morgan Chase Bank, N.A., as an incremental revolving lender and as an issuing bank,... (Filed With SEC on November 2, 2020)

API Supply Agreement, dated November 3, 2010, by and between Cambrex Profarmaco Milano and Horizon Therapeutics Ireland DAC (as successor in interest to Raptor Therapeutics Inc.... (Filed With SEC on November 2, 2020)

Underwriting Agreement, dated August 6, 2020, by and among Horizon Therapeutics Public Limited Company and the several underwriters named therein (Filed With SEC on August 10, 2020)

Horizon Therapeutics Public Limited Company 2020 Equity Incentive Plan and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted Stock Unit Agreement... (Filed With SEC on August 5, 2020)

First Supplemental Indenture, dated November 19, 2019, by and between HZNP Finance Limited and U.S. Bank National Association (Filed With SEC on May 6, 2020)

Second Supplemental Indenture, dated April 23, 2020, by and among Horizon Properties Holding LLC, Curzion Pharmaceuticals, Inc. and U.S. Bank National Association (Filed With SEC on May 6, 2020)

Description of securities registered under Section 12 of the Exchange Act of 1934 (Filed With SEC on February 26, 2020)

Separation Agreement, dated January 23, 2020, by and between Horizon Therapeutics USA, Inc. and Shao-Lee Lin, M.D., Ph.D (Filed With SEC on February 26, 2020)

License Agreement, effective as of June 15, 2011, by and among F. Hoffmann-La Roche Ltd, Hoffman-La Roche Inc. and Horizon Therapeutics Ireland DAC (as successor in interest to... (Filed With SEC on February 26, 2020)

Amendment No. 2 to Commercial Supply Agreement, dated December 18, 2019, by and between AGC Biologics A/S (formerly known as CMC Biologics A/S) and Horizon Therapeutics Ireland DAC (Filed With SEC on February 26, 2020)

Amendment No. 2 to API Supply Agreement, effective as of January 17, 2018, by and between Cambrex Profarmaco Milano and Horizon Therapeutics Ireland DAC (Filed With SEC on February 26, 2020)

Amendment to Supply Agreement, effective as of November 30, 2018, by and between NOF Corporation and Horizon Therapeutics Ireland DAC (Filed With SEC on February 26, 2020)

Mutual Settlement, Release and Media License Agreement, effective as of December 21, 2016, by and between River Vision Development Corp. and Boehringer Ingelheim... (Filed With SEC on November 6, 2019)

Release and Waiver of Claims of Robert F. Carey, dated as of September 18, 2019 (Filed With SEC on November 6, 2019)

Executive Employment Agreement, effective as of November 1, 2019, by and among Horizon Therapeutics Public Limited Company, Horizon Therapeutics USA, Inc. and Andy Pasternak (Filed With SEC on November 6, 2019)

Horizon Pharma Public Limited Company Non-Employee Director Compensation Policy, as amended (Filed With SEC on August 7, 2019)

Amendment No. 1 to Commercial Supply Agreement, dated May 15, 2019, by and between AGC Biologics A/S (formerly known as CMC Biologics A/S) and Horizon Pharma Ireland Limited (Filed With SEC on August 7, 2019)

Indenture dated as of July 16, 2019 by and between Horizon Pharma USA, Inc., the guarantors party thereto and U.S. Bank National Association, as trustee (Filed With SEC on July 16, 2019)

Executive Employment Agreement, effective as of May 1, 2019, by and between Horizon Pharma USA, Inc. and Jeffery Kent, M.D., FACP, FACG (Filed With SEC on May 8, 2019)

Commercial Supply Agreement, effective as of February 14, 2018, by and between CMC Biologics A/S, dba AGC Biologics and Horizon Pharma Ireland Limited (Filed With SEC on May 8, 2019)

Commercial Supply Agreement, effective as of December 18, 2018, by and between Catalent Indiana, LLC and Horizon Pharma Ireland Limited (Filed With SEC on May 8, 2019)

License Agreement, effective as of June 15, 2011, by and among F. Hoffmann-La Roche Ltd, Hoffman-La Roche Inc. and River Vision Development Corp, as amended through Amendment No.... (Filed With SEC on May 8, 2019)

Exclusive License Agreement, dated December 5, 2012, by and between Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center and River Vision Development Corp (Filed With SEC on May 8, 2019)

Horizon Therapeutics Public Limited Company Amended and Restated 2014 Equity Incentive Plan, and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted... (Filed With SEC on May 8, 2019)

Horizon Therapeutics Public Limited Company 2014 Non-Employee Equity Plan, as amended, and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted Stock... (Filed With SEC on May 8, 2019)

Underwriting Agreement, dated March 6, 2019, by and among Horizon Pharma Public Limited Company and the several underwriters named therein (Filed With SEC on March 7, 2019)

Rights Agreement, dated as of February 28, 2019, between Horizon Pharma Public Limited Company and Computershare Trust Company, N.A (Filed With SEC on February 28, 2019)

Third Supplemental Indenture, dated November 15, 2018, by and between Horizon Medicines LLC and U.S. Bank National Association (Filed With SEC on February 27, 2019)

Seventh Supplemental Indenture, dated November 15, 2018, by and between Horizon Medicines LLC and U.S. Bank National Association (Filed With SEC on February 27, 2019)

Horizon Pharma Public Limited Company Non-Employee Director Compensation Policy, as amended (Filed With SEC on February 27, 2019)

Amended and Restated Executive Employment Agreement, effective as of August 1, 2018, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Geoffrey M. Curtis (Filed With SEC on February 27, 2019)

First Supplemental Indenture, dated October 23, 2017, by and between Horizon Pharma Tepro, Inc. and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Second Supplemental Indenture, dated October 19, 2018, by and between Horizon Pharma Services LLC and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Second Supplemental Indenture, dated May 10, 2016, by and between Horizon Pharma Rheumatology LLC and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Third Supplemental Indenture, dated October 25, 2016, by and among Horizon Pharmaceutical LLC, Horizon Orphan LLC and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Fourth Supplemental Indenture, dated October 23, 2017, by and between Horizon Pharma Tepro, Inc. and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Fifth Supplemental Indenture, dated October 19, 2018, by and between Horizon Pharma Services LLC and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Sixth Supplemental Indenture, dated October 31, 2018, by and between Horizon Pharma USA, Inc. and U.S. Bank National Association (Filed With SEC on November 7, 2018)

Confidential Settlement and License Agreement, effective as of September 17, 2018, by and between Horizon Therapeutics, LLC and Par Pharmaceutical, Inc (Filed With SEC on November 7, 2018)

Amendment No. 1 to Amended and Restated License Agreement, dated September 11, 2018, by and between Horizon Orphan LLC and The Regents of the University of California (Filed With SEC on November 7, 2018)

Confidential Settlement and License Agreement, effective as of June 27, 2018, by and among Horizon Therapeutics, LLC, Lupin Ltd. and Lupin Pharmaceuticals, Inc (Filed With SEC on August 8, 2018)

Letter Agreement, dated May 1, 2018, by and between Horizon Pharma USA, Inc. and Sanofi US Services, Inc (Filed With SEC on August 8, 2018)

Amended and Restated Executive Employment Agreement, effective as of March 1, 2018, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Vikram Karnani (Filed With SEC on May 9, 2018)

Horizon Pharma Public Limited Company 2014 Equity Incentive Plan, as amended, and Form of Option Agreement, Form of Stock Option Grant Notice, Forms of Restricted Stock Unit... (Filed With SEC on February 28, 2018)

Horizon Pharma, Inc. Deferred Compensation Plan (Filed With SEC on February 28, 2018)

Executive Employment Agreement, effective as of January 4, 2018, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Shao-Lee Lin, M.D., Ph.D (Filed With SEC on February 28, 2018)

Executive Employment Agreement, effective as of February 16, 2017, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Michael DesJardin (Filed With SEC on February 28, 2018)

First Amendment to Executive Employment Agreement, dated May 4, 2017, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Michael DesJardin (Filed With SEC on February 28, 2018)

Consulting Agreement, effective as of February 1, 2018, by and between Horizon Pharma USA, Inc. and David Happel (Filed With SEC on February 28, 2018)

Second Amendment to Supply Agreement, dated January 1, 2017, by and between Horizon Pharma Ireland Limited and Nuvo Pharmaceuticals Inc. (formerly known as Nuvo Research Inc.) (Filed With SEC on February 28, 2018)

Third Amendment to Supply Agreement, dated February 16, 2018, by and between Horizon Pharma Ireland Limited and Nuvo Pharmaceuticals Inc. (formerly known as Nuvo Research Inc.) (Filed With SEC on February 28, 2018)

Executive Employment Agreement, effective as of September 11, 2017, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Irina Konstantinovsky (Filed With SEC on November 6, 2017)

Executive Employment Agreement, effective as of August 21, 2017, by and among Horizon Pharma, Inc., Horizon Pharma USA, Inc. and Eric Mosbrooker (Filed With SEC on November 6, 2017)

(hereinafterreferred to as HORIZON) (Filed With SEC on August 7, 2017)

AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN HORIZON ORPHANLLC AND THEREGENTS OF THE UNIVERSITY OF CALIFORNIA FOR CASE NOS. SD2006-092, SD2017-110, SD2017-113 AND SD2017-236... (Filed With SEC on August 7, 2017)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND VIKRAM KARNANI (Filed With SEC on August 7, 2017)

HORIZON PHARMA, INC. SECOND AMENDMENT TO AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on August 7, 2017)

HORIZON PHARMA, INC. FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on August 7, 2017)

HORIZON PHARMA, INC. SECOND AMENDMENT TO AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (Filed With SEC on August 7, 2017)

AMENDMENT (Filed With SEC on February 27, 2017)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND DAVID A. HAPPEL (Filed With SEC on February 27, 2017)

AMENDMENT NO. 1 TO SALES CONTRACT (Filed With SEC on February 27, 2017)

FIFTH AMENDMENT TO COMMERCIAL SUPPLY AGREEMENT (Filed With SEC on November 7, 2016)

SECOND AMENDMENT [Drafted as AMENDED AND RESTATED] LICENSE AGREEMENT BETWEEN RAPTOR THERAPEUTICS, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR CASE NO. SD2006-092... (Filed With SEC on November 7, 2016)

API SUPPLY AGREEMENT (Filed With SEC on November 7, 2016)

Manufacturing Services Agreement November 15, 2010 (Filed With SEC on November 7, 2016)

CONFIDENTIAL SETTLEMENT AGREEMENT AND MUTUAL RELEASE (Filed With SEC on November 7, 2016)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND DAVID A. HAPPEL (Filed With SEC on November 7, 2016)

HORIZON PHARMA, INC. and HORIZONPHARMA USA, INC. 8.750% SENIOR NOTES DUE 2024 INDENTURE Dated as of October 25, 2016 U.S. BANKNATIONAL ASSOCIATION, as Trustee TABLE OF CONTENTS (Filed With SEC on October 25, 2016)

AGREEMENT AND PLAN OF MERGER BY AND AMONG HORIZON PHARMA PLC, MISNEACH CORPORATION AND RAPTOR PHARMACEUTICAL CORP. DATED AS OF SEPTEMBER 12, 2016 Table of Contents (Filed With SEC on September 12, 2016)

DATED 18 SEPTEMBER 2015 BETWEEN HORIZON PHARMAPUBLIC LIMITED COMPANY AND GOODBODY TRUSTEES LIMITED HORIZON PHARMA PUBLIC LIMITED COMPANY DIRECTOR SHARE CLOG PROGRAM (Filed With SEC on August 8, 2016)

Amendment No. 2 (hereinafter the Amendment No. 2) to the Consolidated Supply Agreement effective 31 July 2013, (hereinafter the AGREEMENT) (Filed With SEC on August 8, 2016)

COMMERCIAL SUPPLY AGREEMENT between SAVIENT PHARMACEUTICALSINC. and BIO-TECHNOLOGYGENERAL (ISRAEL) LTD. COMMERCIAL SUPPLY AGREEMENT (Filed With SEC on August 8, 2016)

COMMERCIAL SUPPLY AGREEMENT (Filed With SEC on August 8, 2016)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND TIMOTHY J. ACKERMAN (Filed With SEC on May 9, 2016)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND GEOFF CURTIS (Filed With SEC on May 9, 2016)

AGREEMENT AND PLAN OF MERGER byand among HORIZON PHARMA USA, INC., HZNP LIMITED, CRIOSTAIL LLC, CREALTA HOLDINGS LLC, [***] and THE REPRESENTATIVE NAMEDHEREIN December 10, 2015 (Filed With SEC on February 29, 2016)

Horizon Pharma Public Limited Company Non-Employee Director Compensation Policy Amended Effective: November 4, 2015 (Filed With SEC on February 29, 2016)

- 1 - (Filed With SEC on February 29, 2016)

LICENSEAGREEMENT (Filed With SEC on February 29, 2016)

DATED 18 SEPTEMBER 2015 BETWEEN HORIZON PHARMA PUBLIC LIMITED COMPANY AND GOODBODY TRUSTEES LIMITED HORIZON PHARMA PUBLIC LIMITED COMPANY DIRECTOR SHARE CLOG PROGRAM (Filed With SEC on November 6, 2015)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND GEORGE P. HAMPTON (Filed With SEC on November 6, 2015)

CONFIDENTIAL SETTLEMENT AND LICENSE AGREEMENT (Filed With SEC on November 6, 2015)

CONFIDENTIAL SETTLEMENT AND LICENSE AGREEMENT (Filed With SEC on August 7, 2015)

THIRD AMENDMENT TO DISTRIBUTION SERVICES AGREEMENT (Filed With SEC on August 7, 2015)

CREDIT AGREEMENT dated as of May 7, 2015 among HORIZON PHARMA, INC., as Borrower, HORIZON PHARMAPUBLIC LIMITED COMPANY, as Irish Holdco and a Guarantor, THE SUBSIDIARY GUARANTORS... (Filed With SEC on May 11, 2015)

FIRST SUPPLEMENTAL INDENTURE (Filed With SEC on May 11, 2015)

HORIZON PHARMA, INC. DEFERRED COMPENSATION PLAN Effective April 1, 2015 (Filed With SEC on May 8, 2015)

HORIZON PHARMA PUBLIC LIMITED COMPANY EQUITY LONG TERM INCENTIVE PROGRAM EFFECTIVE DATE: MARCH 23, 2015 (Filed With SEC on May 8, 2015)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND BRIAN BEELER (Filed With SEC on May 8, 2015)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND JOHN THOMAS (Filed With SEC on May 8, 2015)

HORIZON PHARMA FINANCING INC. 6.625% SENIOR NOTES DUE 2023 INDENTURE Dated as of April 29, 2015 U.S. BANKNATIONAL ASSOCIATION, Trustee TABLE OF CONTENTS (Filed With SEC on April 29, 2015)

HORIZON PHARMA PUBLIC LIMITED COMPANY 15,350,000 ORDINARY SHARES, NOMINAL VALUE $0.0001 PER SHARE UNDERWRITING AGREEMENT (Filed With SEC on April 16, 2015)

AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware... (Filed With SEC on April 9, 2015)

AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware... (Filed With SEC on March 31, 2015)

TENDER AND SUPPORT AGREEMENT (Filed With SEC on March 31, 2015)

HORIZONPHARMA INVESTMENT LIMITED, as Issuer HORIZON PHARMA PUBLIC LIMITED COMPANY, as Guarantor AND U.S. BANK NATIONALASSOCIATION, as Trustee Indenture Dated as ofMarch 13, 2015... (Filed With SEC on March 13, 2015)

Dated the 4th day of November 2014 JOHN RONAN AND CASTLE COVE PROPERTY DEVELOPMENTS LIMITED (Filed With SEC on February 27, 2015)

ASSET PURCHASE AGREEMENT (Filed With SEC on February 27, 2015)

AMENDMENT TO ASSET PURCHASE AGREEMENT (Filed With SEC on February 27, 2015)

CONSOLIDATED SUPPLY AGREEMENT (Filed With SEC on February 27, 2015)

LICENSE AGREEMENT FOR INTERFERON GAMMA (Filed With SEC on February 27, 2015)

AMENDMENT NO. ONE TO LICENSE AGREEMENT (Filed With SEC on February 27, 2015)

AMENDMENT NO. TWO TO LICENSE AGREEMENT (Filed With SEC on February 27, 2015)

AMENDMENT NO. THREE TO LICENSE AGREEMENT (Filed With SEC on February 27, 2015)

CONSENT TO ASSIGNMENT AGREEMENT BETWEEN CONNETICS AND INTERMUNE PHARMACEUTICALS, INC. JUNE 23, 2000 (Filed With SEC on February 27, 2015)

AMENDMENT No. 6 to the License Agreement for Interferon Gamma (Filed With SEC on February 27, 2015)

SEVENTH AMENDMENT TO LICENSE AGREEMENT FOR INTERFERON GAMMA (Filed With SEC on February 27, 2015)

ASSIGNMENTAND OPTION AGREEMENT BY AND BETWEEN INTERMUNE PHARMACEUTICALS, INC. AND CONNETICSCORPORATION JUNE 23, 2000 (SUPERSEDING AND REPLACING THE AMENDED AND RESTATED EXCLUSIVE... (Filed With SEC on February 27, 2015)

REVENUE ADJUSTMENT AGREEMENT BY AND BETWEEN INTERMUNE PHARMACEUTICALS, INC. AND CONNETICSCORPORATION JUNE 27, 2000 REVENUE ADJUSTMENT AGREEMENT (Filed With SEC on February 27, 2015)

Dated the 16th day of April 2012 BENTON PROPERTY HOLDING LIMITED (IN RECEIVERSHIP) (1) and JIM HAMILTON (2) and VIDARA THERAPEUTICS (3) LICENCE AGREEMENT Re: Unit Nos. 202 and 203... (Filed With SEC on February 27, 2015)

CONSULTING AGREEMENT (Filed With SEC on February 27, 2015)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND BARRY MOZE (Filed With SEC on February 27, 2015)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND JOHN KODY (Filed With SEC on February 27, 2015)

HORIZON PHARMA PUBLIC LIMITEDCOMPANY CASH LONG TERM INCENTIVE PROGRAM EFFECTIVE DATE: NOVEMBER 5, 2014 (Filed With SEC on February 27, 2015)

EXCLUSIVE DISTRIBUTION AGREEMENT - AMENDMENT No. 3 (Filed With SEC on February 27, 2015)

MANUFACTURING AND SUPPLY AGREEMENT - AMENDMENT No. 3 (Filed With SEC on February 27, 2015)

HORIZON PHARMA PUBLIC LIMITED COMPANY ORDINARY SHARES, NOMINAL VALUE $0.0001 PER SHARE UNDERWRITING AGREEMENT (Filed With SEC on November 14, 2014)

HORIZON PHARMA, INC., HORIZONPHARMA PUBLIC LIMITED COMPANY AND U.S. BANK NATIONAL ASSOCIATION, as Trustee FIRST SUPPLEMENTALINDENTURE Dated as of September 19, 2014 5.00%... (Filed With SEC on September 19, 2014)

INDEMNIFICATION AGREEMENT (Filed With SEC on September 19, 2014)

TEMPORARY ESCROW AGREEMENT (Filed With SEC on September 19, 2014)

Horizon Pharma Public Limited Company Non-Employee Director Compensation Policy Effective: September 19, 2014 (Filed With SEC on September 19, 2014)

Horizon Pharma, Inc. Amended and Restated Non-Employee Director Compensation Policy Amended Effective: May 17, 2014 (Filed With SEC on August 7, 2014)

THIRD AMENDMENT TO LEASE (Corporate 500 Centre) (Filed With SEC on August 7, 2014)

Deerfield Management Company, L.P. 780 Third Avenue, 37th Floor NewYork, NY 10017 (Filed With SEC on March 19, 2014)

SECOND AMENDMENT TO LEASE (Corporate 500 Centre) (Filed With SEC on March 13, 2014)

EXCLUSIVE DISTRIBUTION AGREEMENT AMENDMENT No. 2 (Filed With SEC on March 13, 2014)

MANUFACTURING AND SUPPLY AGREEMENT AMENDMENT No. 2 (Filed With SEC on March 13, 2014)

ASSET PURCHASE AGREEMENT By and between AstraZeneca AB and Horizon Pharma USA, Inc. Dated as of November 18, 2013 TABLE OF CONTENTS (Filed With SEC on March 13, 2014)

LICENSE AGREEMENT By and between AstraZeneca AB and Horizon Pharma USA, Inc. Dated as of November 22, 2013 (Filed With SEC on March 13, 2014)

SUPPLY AGREEMENT (Filed With SEC on March 13, 2014)

AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT FOR THE UNITED STATES by and between POZEN INC. and ASTRAZENECA AB November 18, 2013 (Filed With SEC on March 13, 2014)

AMENDMENT NO. 1 TO AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT FOR THE UNITED STATES (Filed With SEC on March 13, 2014)

Master Manufacturing Services Agreement October 31, 2013 (Filed With SEC on March 13, 2014)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND ROBERT F. CAREY (Filed With SEC on March 13, 2014)

HORIZON PHARMA, INC. AND U.S. BANK NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of November 22, 2013 5.00% Convertible Senior Notes due 2018 TABLE OF CONTENTS (Filed With SEC on November 25, 2013)

MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED Mundipharma House -14, Par-la-Ville Road - P.O. Box HM 2332 - Hamilton HM JX -Bermuda Tel: (441) 295-6480 - Fax: (441) 292-1472 a... (Filed With SEC on May 10, 2013)

Horizon Pharma, Inc. Amended and Restated Non-Employee DirectorCompensation Policy Amended Effective: December 14, 2012 (Filed With SEC on March 18, 2013)

FIRST AMENDMENT TO LEASE (Corporate 500 Centre) (Filed With SEC on November 13, 2012)

HORIZON PHARMA, INC. WARRANT TO PURCHASE COMMON STOCK (Filed With SEC on September 20, 2012)

21,425,000 Units Each Unit Consisting of One Share of Common Stock ($0.0001 par value per Share) And A Warrant to Purchase 0.50 of a Share of Common Stock HORIZON PHARMA, INC.... (Filed With SEC on September 20, 2012)

EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND TODD N. SMITH (Filed With SEC on August 10, 2012)

CO-PROMOTION AGREEMENT (Filed With SEC on August 10, 2012)

THIRD LOAN MODIFICATION AGREEMENT (Filed With SEC on March 23, 2012)

English Translation for Convenience Addendum No. 7 to the Lease Agreementof 06.01.2005 / 22.12.2004 Object: Janus-Office-Center, Josef-Meyer-Str. 13-15, 68167 Mannheim (Filed With SEC on March 23, 2012)

HORIZON PHARMA, INC. SEVERANCE BENEFIT PLAN (AS AMENDED AND RESTATED MARCH 1, 2012) (Filed With SEC on March 23, 2012)

HORIZON PHARMA, INC. 2011EQUITY INCENTIVE PLAN RESTRICTED STOCKUNIT AGREEMENT (Filed With SEC on March 23, 2012)

HORIZON PHARMA, INC. WARRANT TO PURCHASE COMMON STOCK (Filed With SEC on March 1, 2012)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on March 1, 2012)

LOAN AND SECURITY AGREEMENT Dated as of February 22, 2012 among HORIZON PHARMA USA, INC. and HORIZON PHARMA, INC. (as Borrowers), CORTLAND CAPITAL MARKET SERVICESLLC (as... (Filed With SEC on March 1, 2012)

GUARANTY AND SECURITY AGREEMENT Dated as of February 22, 2012 by HORIZON PHARMA USA, INC. and HORIZON PHARMA, INC., as the Borrowers, and EACH OTHER GRANTOR FROM TIME TO TIME... (Filed With SEC on March 1, 2012)

HORIZON PHARMA, INC. AMENDMENT TO INVESTORS RIGHTS AGREEMENT (Filed With SEC on March 1, 2012)

STANDARD OFFICE LEASE BY AND BETWEEN LONG RIDGE OFFICE PORTFOLIO, L.P., a Delaware limited partnership, AS LANDLORD, AND HORIZON PHARMA USA, INC., a Delaware corporation, AS... (Filed With SEC on November 14, 2011)

CONSENT AND FIRST LOAN MODIFICATION AGREEMENT (Filed With SEC on November 14, 2011)

SECOND LOAN MODIFICATION AGREEMENT (Filed With SEC on November 14, 2011)

[ ] Shares HORIZON PHARMA, INC. Common Stock ($0.0001 par value per Share) UNDERWRITING AGREEMENT (Filed With SEC on July 11, 2011)

CONVERSION AND AMENDMENT AGREEMENT (Filed With SEC on July 11, 2011)

INDEMNIFICATION AGREEMENT (Filed With SEC on July 11, 2011)

HORIZON PHARMA, INC. 2011EQUITY INCENTIVE PLAN ADOPTED BYTHE BOARD OF DIRECTORS: March 31, 2011 APPROVED BY THE STOCKHOLDERS: June 16, 2011 TERMINATION DATE: March 30, 2021 (Filed With SEC on July 11, 2011)

HORIZON PHARMA, INC. 2011EMPLOYEE STOCK PURCHASE PLAN ADOPTEDBY THE BOARD OF DIRECTORS: MARCH 31, 2011 APPROVED BY THE STOCKHOLDERS: JUNE 16, 2011 (Filed With SEC on July 11, 2011)

Horizon Pharma, Inc. Non-Employee Director Compensation Policy Effective: Upon the effectiveness of the IPO (Filed With SEC on July 11, 2011)

[ ] Shares HORIZON PHARMA, INC. Common Stock ($0.0001 par value per Share) UNDERWRITING AGREEMENT (Filed With SEC on June 7, 2011)

WARRANT TO PURCHASE STOCK ( in a series of3) (Filed With SEC on June 7, 2011)

WARRANT TO PURCHASE STOCK (Filed With SEC on June 7, 2011)

HORIZON PHARMA, INC. WARRANT TO PURCHASE SERIES B PREFERRED STOCK (Filed With SEC on June 7, 2011)

HORIZON PHARMA, INC. 2011EQUITY INCENTIVE PLAN ADOPTED BYTHE BOARD OF DIRECTORS: March 31, 2011 APPROVED BY THE STOCKHOLDERS: , 2011 TERMINATIONDATE: March 30, 2021 (Filed With SEC on June 7, 2011)

HORIZON PHARMA, INC. 2011EMPLOYEE STOCK PURCHASE PLAN ADOPTEDBY THE BOARD OF DIRECTORS: MARCH 31, 2011 APPROVED BY THE STOCKHOLDERS: , 2011 (Filed With SEC on June 7, 2011)

LOAN AND SECURITY AGREEMENT Dated as of June 2, 2011 among HORIZON PHARMA USA, INC., HORIZON PHARMA, INC., and HORIZON PHARMA (UK) LIMITED, (as Borrowers), OXFORD FINANCE LLC (as... (Filed With SEC on June 7, 2011)

Transfer, License and Supply Agreement between Merck Pharma GmbH Alsfelder Straße 17, 64289 Darmstadt, Germany (Merck), and Nitec Pharma AG Röschenzerstr. 9, 4153 Reinach,... (Filed With SEC on June 7, 2011)

CONFIDENTIAL (Filed With SEC on June 7, 2011)

1033 Skokie Boulevard, Suite 355 Northbrook, IL 60062 (Filed With SEC on June 7, 2011)

MANUFACTURING AND SUPPLY AGREEMENT (HZT-501 LAUNCH STOCKS AND COMMERCIAL QUANTITIES) (Filed With SEC on June 7, 2011)

SECOND AMENDMENT TO AGREEMENT FOR THE PROVISION OF A LOAN FACILITY OF UPTO EURO 7,500,000 (Filed With SEC on June 7, 2011)

DATED 20 AUGUST 2004 JAGOTEC AG and SKYEPHARMA AG and NITEC PHARMA AG DEVELOPMENT & LICENCE AGREEMENT (Filed With SEC on April 1, 2011)

English Translation for Convenience LEASE AGREEMENT for rented commercial premises (Filed With SEC on April 1, 2011)

AMENDMENT TO MANUFACTURING & SUPPLY AGREEMENT (Filed With SEC on April 1, 2011)

[Signatures next page] (Filed With SEC on April 1, 2011)

DATED NOVEMBER 4, 2010 HORIZON PHARMA AG AND MUNDIPHARMA MEDICAL COMPANY MANUFACTURINGAND SUPPLY AGREEMENT MANUFACTURING AND SUPPLY AGREEMENT (Filed With SEC on April 1, 2011)

DATED NOVEMBER 4, 2010 HORIZON PHARMA AG AND MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED EXCLUSIVE DISTRIBUTION AGREEMENT EXCLUSIVE DISTRIBUTION AGREEMENT (Filed With SEC on April 1, 2011)

HORIZON PHARMA, INC. 2010 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: , 2010 APPROVEDBY THE STOCKHOLDERS: , 2010 TERMINATION DATE: , 2020 (Filed With SEC on November 5, 2010)

HORIZON PHARMA, INC. 2010 EMPLOYEE STOCK PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: , 2010 APPROVEDBY THE STOCKHOLDERS: , 2010 (Filed With SEC on November 5, 2010)

Horizon Pharma, Inc. Non-Employee Director Compensation Policy Effective: Upon theeffectiveness of the IPO (Filed With SEC on November 5, 2010)

DATED NOVEMBER 4, 2010 HORIZON PHARMA AG AND MUNDIPHARMA MEDICAL COMPANY MANUFACTURINGAND SUPPLY AGREEMENT MANUFACTURING ANDSUPPLY AGREEMENT (Filed With SEC on November 5, 2010)

DATED NOVEMBER 4, 2010 HORIZON PHARMA AG AND MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED EXCLUSIVE DISTRIBUTION AGREEMENT EXCLUSIVEDISTRIBUTION AGREEMENT (Filed With SEC on November 5, 2010)

DATED 20 AUGUST 2004 JAGOTEC AG and SKYEPHARMA AG and NITEC PHARMA AG DEVELOPMENT & LICENCE AGREEMENT (Filed With SEC on October 21, 2010)

MANUFACTURING & SUPPLY AGREEMENT (Filed With SEC on October 21, 2010)

Technology Transfer Agreement between Merck KGaA (Merck), Frankfurter Strasse 250, 64271 Darmstadt and Nitec Pharma AG (Nitec Pharma) Switzerland Preamble (Filed With SEC on October 21, 2010)

Transfer, License and Supply Agreement between Merck Pharma GmbH Alsfelder Straße 17, 64289 Darmstadt, Germany (Merck), and Nitec Pharma AG Röschenzerstr. 9, 4153 Reinach,... (Filed With SEC on October 21, 2010)

Transfer, License and Supply Agreement between Merck GesmbH Zimbagasse 5 A-1147 Vienna, Austria (Merck), and Nitec Pharma AG Kagenstr 17, 4153 Reinach, Switzerland (Nitec AG) and... (Filed With SEC on October 21, 2010)

DATED 24th March 2009 NITEC PHARMA AG AND MUNDIPHARMA MEDICAL COMPANY MANUFACTURINGAND SUPPLY AGREEMENT MANUFACTURING AND SUPPLY AGREEMENT (Filed With SEC on October 21, 2010)

DATED 24th March 2009 NITEC PHARMA AG AND MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED EXCLUSIVE DISTRIBUTION AGREEMENT (Filed With SEC on October 21, 2010)

TECHNICAL TRANSFER AGREEMENT (Filed With SEC on October 21, 2010)

English Translation for Convenience LEASE AGREEMENT for rented commercial premises (Filed With SEC on October 21, 2010)

PACKAGING and SUPPLY AGREEMENT for the packaging of pharmaceuticals between (Filed With SEC on October 21, 2010)

Master Services Agreement (Filed With SEC on October 21, 2010)

HORIZON PHARMA, INC. INVESTORS RIGHTS AGREEMENT April 1, 2010 Horizon Pharma, Inc. INVESTORS RIGHTS AGREEMENT (Filed With SEC on October 8, 2010)

[Signatures next page] (Filed With SEC on October 8, 2010)

SHARE EXCHANGE AGREEMENT Dated April 1, 2010 by and among (Filed With SEC on August 3, 2010)

HORIZON THERAPEUTICS, INC. WARRANT TO PURCHASE STOCK (Filed With SEC on August 3, 2010)

WARRANT AGREEMENT To Purchase Shares of the Series C Preferred Stock of HORIZON THERAPEUTICS, INC. Dated as of December 18, 2007 (the Effective Date) (Filed With SEC on August 3, 2010)

WARRANT AGREEMENT To Purchase Shares of the Series C Preferred Stock of HORIZON THERAPEUTICS, INC. Dated as of November 21, 2008 (the Effective Date) (Filed With SEC on August 3, 2010)

HORIZON PHARMA, INC. WARRANT TO PURCHASE SERIES A PREFERRED STOCK (Filed With SEC on August 3, 2010)

HORIZON PHARMA, INC. WARRANT TO PURCHASE SERIES B PREFERRED STOCK (Filed With SEC on August 3, 2010)

WARRANT TO PURCHASE STOCK (No. PBW-2) (Filed With SEC on August 3, 2010)

HORIZON PHARMA, INC. INDEMNITY AGREEMENT (Filed With SEC on August 3, 2010)

HORIZON PHARMA, INC. 2005 STOCK PLAN ADOPTED BY THE BOARD OF DIRECTORS:OCTOBER 17, 2005 APPROVED BY STOCKHOLDERS:OCTOBER 17, 2005 AMENDED BY THE BOARDOF DIRECTORS: JULY 18, 2007... (Filed With SEC on August 3, 2010)

LOAN AND SECURITY AGREEMENT Dated as of April 1, 2010 among HORIZON PHARMA USA, INC. and NITEC PHARMA AG, (as Borrowers), HORIZON PHARMA, INC. (as Guarantor), KREOS CAPITAL III... (Filed With SEC on August 3, 2010)

AGREEMENT FOR THE PROVISION OF A LOAN FACILITY OF UP TO EURO 7,500,000 Date 15/8/2008 Between (Filed With SEC on August 3, 2010)

DATED 20 AUGUST 2004 JAGOTEC AG and SKYEPHARMA AG and NITEC PHARMA AG DEVELOPMENT & LICENCEAGREEMENT (Filed With SEC on August 3, 2010)

MANUFACTURING & SUPPLY AGREEMENT (Filed With SEC on August 3, 2010)

Technology Transfer Agreement between Merck KGaA (Merck), Frankfurter Strasse 250, 64271 Darmstadt and NitecPharma AG (Nitec Pharma) Switzerland Preamble (Filed With SEC on August 3, 2010)

Transfer, License and Supply Agreement between Merck Pharma GmbH Alsfelder Straße 17, 64289 Darmstadt, Germany (Merck), and Nitec Pharma AG Röschenzerstr. 9, 4153 Reinach,... (Filed With SEC on August 3, 2010)

Agreement between Merck Pharma GmbH Alsfelder Straße 17 64289 Darmstadt, Germany (Merck) and NitecPharma AG Kägenstraße 17 4153 Reinach, Switzerland (Nitec AG) and NitecGmbH... (Filed With SEC on August 3, 2010)

Transfer, License and Supply Agreement between Merck GesmbH Zimbagasse 5 A-1147 Vienna, Austria (Merck), and NitecPharma AG Kagenstr 17, 4153 Reinach, Switzerland (Nitec AG) and... (Filed With SEC on August 3, 2010)

EMPLOYEE CONFIDENTIALITY AND INVENTIONS ASSIGNMENT AGREEMENT (Filed With SEC on August 3, 2010)

DATED24th March 2009 NITEC PHARMA AG AND MUNDIPHARMA MEDICAL COMPANY MANUFACTURINGAND SUPPLY AGREEMENT MANUFACTURING AND SUPPLY AGREEMENT (Filed With SEC on August 3, 2010)

DATED 24th March 2009 NITEC PHARMA AG AND MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED EXCLUSIVE DISTRIBUTION AGREEMENT (Filed With SEC on August 3, 2010)

MUNDIPHARMA INTERNATIONALCORPORATION LIMITED Mundipharma House 14, Par-la-Ville Road P.O. Box HM 2332 Hamilton HM JX Bermuda Tel: (441) 295-6480 Fax: (441) 292-1472 a member of... (Filed With SEC on August 3, 2010)

TECHNICAL TRANSFER AGREEMENT (Filed With SEC on August 3, 2010)

SUBLEASE (Filed With SEC on August 3, 2010)

English Translation for Convenience LEASE AGREEMENT for rented commercial premises (Filed With SEC on August 3, 2010)

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND TIMOTHY P. WALBERT (Filed With SEC on August 3, 2010)

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND ROBERT J. DE VAERE (Filed With SEC on August 3, 2010)

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT BY AND BETWEEN HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND JEFFREY W. SHERMAN, M.D. (Filed With SEC on August 3, 2010)

PACKAGING and SUPPLY AGREEMENT for the packaging of pharmaceuticals between (Filed With SEC on August 3, 2010)

Master Services Agreement (Filed With SEC on August 3, 2010)

HORIZON PHARMA, INC. SEVERANCE BENEFIT PLAN (Filed With SEC on August 3, 2010)

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