IONIS PHARMACEUTICALS INC Contracts & Agreements

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Isis Pharmaceuticals, Inc. Requests that the marked portions of the exhibit be granted confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.
IONIS PHARMACEUTICALS INC
Biotechnology
2012
Underwriting Agreement, dated September 9, 2024
Underwriting Agreements
IONIS PHARMACEUTICALS INC
2024
Second Amendment dated as of June 11, 2024 to the Amended and Restated Lease Agreement dated as of August 21, 2023 by and between the Registrant and Lots 21 and 22 Owner (DE) LLC,...
Lease Agreements
IONIS PHARMACEUTICALS INC
2024
Advisory Services Agreement by and between the Registrant and Onaiza Cadoret-Manier dated March 15, 2024
Services Agreements
IONIS PHARMACEUTICALS INC
2024
Form of Indemnity Agreement entered into between the Registrant and its Directors and Executive Officers with related schedule
IONIS PHARMACEUTICALS INC
2024
First Amendment dated as of November 6, 2023 to Amended and Restated Lease Agreement between the Registrant and Lots 21 & 22 Owner (DE) LLC dated as of August 21, 2023
Lease Agreements
IONIS PHARMACEUTICALS INC
2024
Collaboration and License Agreement by and between the Registrant and Novartis Pharma AG dated as of August 2, 2023. Portions of this exhibit have been omitted because they are...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2023
Amended and Restated Lease Agreement between the Registrant and Lots 21 & 22 Owner (DE) LLC dated as of August 21, 2023. Portions of this exhibit have been omitted because they...
Lease Agreements
IONIS PHARMACEUTICALS INC
2023
Research, Development, and License Agreement by and among the Registrant, F. Hoffmann-La Roche Ltd., and Hoffmann-La Roche Inc. dated as of September 26, 2023. Portions of this...
License Agreements
IONIS PHARMACEUTICALS INC
2023
Amendment No. 3 dated April 27, 2023 to the Collaboration and License Agreement by and between the Registrant and BicycleTx Limited dated July 9, 2021. Portions of this exhibit...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2023
First Amendment dated June 15, 2023 to the Purchase and Sale Agreement by and between the Registrant and Oxford I Asset Management USA Inc. dated as of October 20, 2022
Purchase Agreements
IONIS PHARMACEUTICALS INC
2023
Letter Agreement dated June 29, 2023 in reference to the Collaboration and License Agreement dated December 6, 2021 by and between Akcea Therapeutics, Inc. and AstraZeneca AB....
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2023
Indenture, dated as of June 12, 2023, by and between the Company and U.S. Bank Trust Company, National Association, as Trustee
Indenture Agreements
IONIS PHARMACEUTICALS INC
2023
Second Amended Non-Employee Director Compensation Policy
Compensation Agreements
IONIS PHARMACEUTICALS INC
2023
Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors Stock Option Plan, as amended on March 14, 2023
Stock Agreements
IONIS PHARMACEUTICALS INC
2023
Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement for Restricted Stock Units granted under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002...
Stock Agreements
IONIS PHARMACEUTICALS INC
2023
HTT Research, Development, Option and License Agreement among the Registrant, F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., dated as of April. 8, 2013
License Agreements
IONIS PHARMACEUTICALS INC
2023
Form of Option Agreement for Options granted under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors Stock Option Plan
Stock Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2023
Form of Option Agreement under the 2011 Equity Incentive Plan
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2023
Form of Time-Vested Restricted Stock Unit Agreement for Restricted Stock Units granted under the 2011 Equity Incentive Plan
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
2023
Forms of Performance Based Restricted Stock Unit Grant Notice and Performance Based Restricted Stock Unit Agreement for Performance Based Restricted Stock Units granted beginning...
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
2023
Amendment No. 2 dated July 28, 2022 to the Collaboration and License Agreement by and between the Registrant and BicycleTx Limited dated July 9, 2021. Portions of this exhibit...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2022
First Amendment dated July 8, 2022 to Factor B Development, Collaboration, Option and License Agreement by and between the Registrant, F. Hoffmann-La Roche Ltd and Hoffmann-La...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2022
Amended and Restated Ionis Pharmaceuticals, Inc. Severance Benefit Plan
Severance Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
MA
2022
Description of the Registrants Securities
IONIS PHARMACEUTICALS INC
Biotechnology
2022
Forms of Performance Based Restricted Stock Unit Grant Notice and Performance Based Restricted Stock Unit Agreement for Performance Based Restricted Stock Units granted under the...
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
2022
Fourth Amended and Restated Strategic Advisory Services Agreement by and between the Registrant and B. Lynne Parshall, dated February 22, 2022
Services Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2022
Amendment No. 1 dated December 17, 2021 to the Collaboration and License Agreement by and between the Registrant and BicycleTX Limited dated July 9, 2021. Portions of this exhibit...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2022
Amended and Restated Neurology Drug Discovery and Development Collaboration, Option and License Agreement Between Ionis Pharmaceuticals, Inc., And Biogen MA Inc. Dated July 12,...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2021
COLLABORATION AND LICENSE AGREEMENT between BICYCLETX LIMITED and IONIS PHARMACEUTICALS, INC. Dated as of July 9, 2021
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2021
Non-Employee Director Compensation Policy Amended June 2, 2021
Compensation Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2021
[Signature page to follow]
IONIS PHARMACEUTICALS INC
2021
Non-Employee Director Compensation Policy
Compensation Agreements
IONIS PHARMACEUTICALS INC
2021
Indenture, dated as of April 12, 2021, by and between the Company and U.S. Bank National Association, as Trustee
Indenture Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2021
Form of Convertible Note Hedge Confirmation
Note Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2021
Form of Warrant Confirmation
Warrant Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2021
Forms of Performance Based Restricted Stock Unit Grant Notice and Performance Based Restricted Stock Unit Agreement for Performance Based Restricted Stock Units granted under the...
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
CA
2021
Research Collaboration, Option and License Agreement between the Registrant and Janssen Biotech Inc. dated December 22, 2014. Portions of this exhibit have been omitted because...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2021
First Amendment to Research Collaboration, Option and License Agreement between the Registrant and Janssen Biotech Inc. dated December 21, 2016. Portions of this exhibit have been...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2021
Third Amended and Restated Strategic Advisory Services Agreement by and between the Registrant and B. Lynne Parshall, dated February 22, 2021
Services Agreements
IONIS PHARMACEUTICALS INC
2021
Amendment No. 3 dated December 17, 2020 to the Strategic Collaboration Agreement by and between the Registrant and AstraZeneca AB dated July 31, 2015. Portions of this exhibit...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2021
Strategic Advisory Services Agreement by and between the Registrant and Stanley T. Crooke, dated December 17, 2020
Services Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2021
Side Letter dated December 31, 2020 to the New Strategic Neurology Drug Discovery and Development Collaboration, Option and License Agreement by and between the Registrant and...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2021
Agreement and Plan of Merger, dated as of August 30, 2020, among Akcea Therapeutics, Inc., Ionis Pharmaceuticals, Inc. and Avalanche Merger Sub, Inc
Merger Agreements
IONIS PHARMACEUTICALS INC
2020
Side Letter dated June 11, 2020 to the Second Amended and Restated Strategic Neurology Drug Discovery and Development Collaboration, Option and License Agreement by and between...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2020
Amendment No. 2 to the Strategic Collaboration Agreement by and between the Registrant and AstraZeneca AB dated July 31, 2015 (portions of the exhibit have been omitted because...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2020
Description of the Registrants Securities
IONIS PHARMACEUTICALS INC
2020
Letter Agreement between the Registrant, Akcea Therapeutics, Inc., and Pfizer Inc., dated October 4, 2019. Portions of this exhibit have been omitted because they are both (i) not...
IONIS PHARMACEUTICALS INC
Biotechnology
2020
Performance Based Restricted Stock Unit Grant Notice and Performance Based Restricted Stock Unit Agreement
Bonus & Incentive Agreements
IONIS PHARMACEUTICALS INC
2020
Second Amended and Restated Advisory Services Agreement dated January 9, 2020
Services Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2020
Indenture, dated as of December 19, 2019, by and between Ionis Pharmaceuticals, Inc. and U.S. Bank National Association, as trustee
Indenture Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2019
Amendment No. 1 to the Neurology III Agreement between the Registrant and Biogen MA Inc., dated August 16, 2019 (portions of the exhibit have been omitted because they are both...
IONIS PHARMACEUTICALS INC
Biotechnology
2019
Amendment #8 to the Research, Development and License Agreement between the Registrant, Glaxo Group Limited and Glaxosmithkline Intellectual Property Development Limited, dated...
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2019
Consent to Collateral Addition and Amendment to Loan Documents between the Registrant, Ionis Gazelle, LLC, Wells Fargo Bank, National Association, as Trustee for the Benefit of...
Loan Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2019
Amendment No. 1 to Second Amended and Restated Strategic Neurology Drug Discovery and Development Collaboration, Option and License Agreement by and between the Registrant and...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2019
Amended and Restated Advisory Services Agreement dated March 22, 2019
Services Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2019
Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan
Stock Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2019
Factor B Development Collaboration, Option and License Agreement by and between the Registrant, F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., dated October 9, 2018....
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
CA
2019
Second Amendment to Research Collaboration, Option and License Agreement of December 22, 2014, by and between Ionis Pharmaceuticals, Inc. and Janssen Biotech Inc. Portions of this...
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2018
Ionis Severance Benefit Plan and Summary Plan Description dated October 18, 2018
Severance Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2018
Strategic Advisory Services Agreement, dated as of January 15, 2018, by and between B. Lynne Parshall and Ionis Pharmaceuticals, Inc
Services Agreements
IONIS PHARMACEUTICALS INC
2018
Development, Commercialization, Collaboration, and License Agreement, dated as of March 14, 2018, by and between Ionis Pharmaceuticals, Inc. and Akcea Therapeutics, Inc
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2018
Amended and Restated Services Agreement, dated as of March 14, 2018, by and between Ionis Pharmaceuticals, Inc. and Akcea Therapeutics, Inc
Services Agreements
IONIS PHARMACEUTICALS INC
2018
IONIS CODE OF ETHICS AND BUSINESS CONDUCT PHILOSOPHY OF IONIS CODE OF ETHICS AND BUSINESS CONDUCT
Code of Ethics
IONIS PHARMACEUTICALS INC
2018
ISIS PHARMACEUTICALS, INC.
IONIS PHARMACEUTICALS INC
Biotechnology
2018
IONIS PHARMACEUTICALS, INC. EMPLOYEE CONFIDENTIAL INFORMATION AND INVENTIONS AGREEMENT
IONIS PHARMACEUTICALS INC
2018
Strategic Collaboration, Option and License Agreement Between Akcea Therapeutics, Inc. And Novartis Pharma AG
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2017
STOCK PURCHASE AGREEMENT
Stock Agreements
IONIS PHARMACEUTICALS INC
2017
AMENDMENT #1 TO THE LICENSE AGREEMENT, DATED MAY 1ST, 2015
License Agreements
IONIS PHARMACEUTICALS INC
2017
225 Binney Street, Cambridge, MA 02142 " Phone ###-###-#### " www.biogen.com
IONIS PHARMACEUTICALS INC
2017
AMENDMENT NO.3
IONIS PHARMACEUTICALS INC
2016
AMENDMENT #7 TO THE RESEARCH, DEVELOPMENT AND LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2016
AMENDMENT NO. 2 TO LINE OF CREDIT AGREEMENT
Credit Agreements
IONIS PHARMACEUTICALS INC
2016
Amendment No.1 to Loan Documents between Ionis Pharmaceuticals, Inc. and Morgan Stanley Private Bank, National Association dated December 30, 2015
Loan Agreements
IONIS PHARMACEUTICALS INC
2016
CONFIDENTIAL TREATMENT REQUESTEDUNDER 17 C.F.R 200.80(B)4, AND 240.24B-2 Exhibit 10.1ConfidentialExecution CopyLicense Agreement Between Isis Pharmaceuticals, Inc., And Bayer...
IONIS PHARMACEUTICALS INC
2015
SECOND AMENDED AND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2015
AMENDMENT #1 TO HTT RESEARCH, DEVELOPMENT, OPTION AND LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
2015
[Signature page follows]
IONIS PHARMACEUTICALS INC
2015
Research Collaboration, Option and License Agreement Between Isis Pharmaceuticals, Inc. And Janssen Biotech Inc.
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2015
AMENDMENT NO.2
IONIS PHARMACEUTICALS INC
Biotechnology
2015
ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of November 17, 2014 1.00% Convertible Senior Notes due 2021
Indenture Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2014
EXCLUSIVE LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
MA
2014
Amended and Restated Collaboration and License Agreement
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2014
Amendment to Amended and Restated Collaboration and License Agreement relating to [***]
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2014
Amendment No. 3 to the Research, Development and License Agreement between the Registrant and Glaxo Group Limited dated July 10, 2013. Portions of this exhibit have been omitted...
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2014
Amendment #4 to the Research, Development and License Agreement between the Registrant and Glaxo Group Limited dated April 10, 2014. Portions of this exhibit have been omitted and...
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2014
Amendment #5 to the Research, Development and License Agreement among the Registrant, Glaxo Group Limited and GlaxoSmithKline Intellectual Property Development Limited dated June...
License Agreements
IONIS PHARMACEUTICALS INC
2014
Letter Agreement Amendment between the Registrant and Biogen Idec International Holding Ltd dated January 27, 2014. Portions of this exhibit have been omitted and separately filed...
IONIS PHARMACEUTICALS INC
Biotechnology
2014
HTT RESEARCH, DEVELOPMENT, OPTION AND LICENSE AGREEMENT AMONG ISIS PHARMACEUTICALS, INC., AND F. HOFFMANN-LA ROCHE LTD AND HOFFMANN-LA ROCHE INC.
License Agreements
IONIS PHARMACEUTICALS INC
2013
Isis Pharmaceuticals, Inc. 9,000,000 shares of common stock, par value $0.001 per share Underwriting Agreement
Underwriting Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2013
INDEMNITY AGREEMENT
IONIS PHARMACEUTICALS INC
2013
AMENDMENT #2 TO RESEARCH, DEVELOPMENT AND LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
2013
COLLABORATION, LICENSE AND DEVELOPMENT AGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND ASTRAZENECA AB
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2013
NEUROLOGY DRUG DISCOVERY AND DEVELOPMENT COLLABORATION, OPTION AND LICENSE AGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND BIOGEN IDEC MA INC.
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2013
ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of August 13, 2012 2.75% Convertible Senior Notes due 2019
Indenture Agreements
IONIS PHARMACEUTICALS INC
2012
DMPK RESEARCH, DEVELOPMENT, OPTION AND LICENSE AGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND BIOGEN IDEC MA INC.
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2012
THIRD AMENDMENT TO LOAN AGREEMENT
Loan Agreements
IONIS PHARMACEUTICALS INC
2012
ISIS PHARMACEUTICALS, INC. RESTRICTED STOCK UNIT GRANT NOTICE (AMENDED & RESTATED 2002 NON-EMPLOYEE DIRECTORS STOCK OPTION PLAN)
Stock Agreements
IONIS PHARMACEUTICALS INC
2012
DEVELOPMENT, OPTION AND LICENSE AGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND BIOGEN IDEC INTERNATIONAL HOLDING LTD
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2012
RESEARCH AGREEMENT
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2011
AMENDMENT #1 TO RESEARCH, DEVELOPMENT AND LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2011
SECOND AMENDMENT TO LEASE AGREEMENT
Lease Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2011
SECOND AMENDMENT TO LOAN AGREEMENT
Loan Agreements
IONIS PHARMACEUTICALS INC
2011
FIRSTAMENDMENT TOCOLLABORATION RESEARCH AND LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2010
COLLABORATION AND LICENSE AGREEMENT between REGULUS THERAPEUTICS INC. And SANOFI-AVENTIS
Collaboration Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2010
NON-EXCLUSIVE TECHNOLOGY ALLIANCE AND OPTION AGREEMENT between REGULUS THERAPEUTICS INC. and SANOFI-AVENTIS
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2010
AMENDMENT NUMBER ONE TO THE AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2010
AMENDMENT NUMBER ONE TO THE FOUNDING INVESTOR RIGHTS AGREEMENT
Investor Rights Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2010
AMENDMENT #1 TO THE PRODUCTDEVELOPMENT AND COMMERCIALIZATION AGREEMENT
IONIS PHARMACEUTICALS INC
2010
EXCLUSIVE LICENSEAND NONEXCLUSIVE OPTION AGREEMENT BETWEEN GLAXO GROUPLIMITED AND REGULUSTHERAPEUTICS INC.
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2010
LEASEAGREEMENT
IONIS PHARMACEUTICALS INC
Biotechnology
CA
2010
ARTICLE36 OPTIONTO EXTEND
IONIS PHARMACEUTICALS INC
2010
RESEARCH, DEVELOPMENT AND LICENSEAGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND GLAXO GROUP LIMITED
Development Agreements
IONIS PHARMACEUTICALS INC
2010
DRUGDEVELOPMENT AND LICENSE OPTION AGREEMENT BETWEEN ELILILLY AND COMPANY AND ISISPHARMACEUTICALS, INC. December 2,2009
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2010
AMENDED &RESTATED LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2010
FIRST AMENDMENT TO LOAN AGREEMENT
Loan Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2010
AMENDMENTNO. 1 TO AMENDEDAND RESTATED LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
2010
LOAN AGREEMENT
Loan Agreements
IONIS PHARMACEUTICALS INC
2009
REGULUS THERAPEUTICS LLC EMPLOYMENT AGREEMENT
Employment Agreements
IONIS PHARMACEUTICALS INC
2009
C O N F I D E N T I A L PRE-CLINICAL DEVELOPMENTCOLLABORATION AGREEMENT
IONIS PHARMACEUTICALS INC
2009
STOCK PURCHASE AGREEMENT by and among IBIS BIOSCIENCES, INC., ISIS PHARMACEUTICALS, INC. and ABBOTT MOLECULAR INC. Dated: December 17, 2008
Stock Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
IL
2009
EXHIBIT A SEPARATIONAGREEMENT
IONIS PHARMACEUTICALS INC
Biotechnology
2008
EXHIBIT A SEPARATIONAGREEMENT
IONIS PHARMACEUTICALS INC
Biotechnology
2008
Isis Policy andProcedures Manual
IONIS PHARMACEUTICALS INC
2008
AMENDEDAND RESTATED LICENSE AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
2008
LICENSE AND RESEARCH AGREEMENT
License Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
IL
2008
AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2008
CONFIDENTIAL TREATMENTREQUESTED UNDER 17 C.F.R 200.80(b)4,AND 240.24b-2
IONIS PHARMACEUTICALS INC
2008
STRATEGICALLIANCE MASTER AGREEMENT AMONG IBISBIOSCIENCES, INC. ISISPHARMACEUTICALS, INC. AND ABBOTTMOLECULAR INC. January 30, 2008
IONIS PHARMACEUTICALS INC
2008
CALL OPTION AGREEMENT BY AND AMONG ISIS PHARMACEUTICALS, INC., IBIS BIOSCIENCES, INC. AND ABBOTT MOLECULAR INC. January 30, 2008
IONIS PHARMACEUTICALS INC
Biotechnology
DE
2008
AMENDMENT NO. 1 TO SALE AGREEMENT
IONIS PHARMACEUTICALS INC
Biotechnology
2007
RETENTION AGREEMENT
Retention Agreements
IONIS PHARMACEUTICALS INC
2007
COLLABORATIONAND LICENSE AGREEMENT between ISIS PHARMACEUTICALS, INC. and BRISTOL-MYERSSQUIBB COMPANY
License Agreements
IONIS PHARMACEUTICALS INC
2007
AMENDMENT NO. 1
IONIS PHARMACEUTICALS INC
Biotechnology
2007
LICENSEAGREEMENT
IONIS PHARMACEUTICALS INC
2007
EXHIBIT A FORM OF SEPARATION AGREEMENT
Separation Agreements
IONIS PHARMACEUTICALS INC
2007
ISISPHARMACEUTICALS, INC.
IONIS PHARMACEUTICALS INC
2007
REGISTRATION RIGHTSAGREEMENT BY AND BETWEEN ISIS PHARMACEUTICALS,INC., AS ISSUER AND LEHMAN BROTHERS INC., ASREPRESENTATIVE OF THE INITIAL PURCHASERS DATED AS OF JANUARY 23,2007
IONIS PHARMACEUTICALS INC
2007
$125,000,000 ISISPHARMACEUTICALS, INC. 2 58%Convertible Subordinated Notes due 2027 PURCHASEAGREEMENT
Note Agreements
IONIS PHARMACEUTICALS INC
2007
MANUFACTURING, COMMERCIALIZATION AND DEVELOPMENT AGREEMENT
Development Agreements
IONIS PHARMACEUTICALS INC
2006
CONFIDENTIALTREATMENT REQUESTED UNDER 17 C.F.R. 200.80(b)4, AND 240.24b-2
IONIS PHARMACEUTICALS INC
2006
CONFIDENTIAL TREATMENTREQUESTED UNDER 17 C.F.R. 200.80(b)4, AND 240.24b-2
IONIS PHARMACEUTICALS INC
Biotechnology
2006
CONFIDENTIAL TREATMENTREQUESTED UNDER 17 C.F.R. 200.80(b)4, AND 240.24b-2
IONIS PHARMACEUTICALS INC
2006
CONFIDENTIAL TREATMENTREQUESTED UNDER 17 C.F.R. 200.80(b)4, AND 240.24b-2
IONIS PHARMACEUTICALS INC
2006
ISISPHARMACEUTICALS, INC. WARRANTTO PURCHASE COMMON STOCK
Stock Agreements
IONIS PHARMACEUTICALS INC
Biotechnology
NY
2006
LEASEAGREEMENT
IONIS PHARMACEUTICALS INC
2005
RESTATEDISIS PHARMACEUTICALS, INC. 10B5-1 TRADING PLAN
IONIS PHARMACEUTICALS INC
2005
SECONDAMENDED AND RESTATED COLLABORATION AGREEMENT BETWEEN ELI LILLYAND COMPANY AND ISISPHARMACEUTICALS, INC. August 5,2005
Collaboration Agreements
IONIS PHARMACEUTICALS INC
2005
NOTICE OF GRANT AWARD
IONIS PHARMACEUTICALS INC
2005
SUBCONTRACT AGREEMENT Time and Material /Labor Hour
IONIS PHARMACEUTICALS INC
2005
COLLABORATIVE RESEARCH AGREEMENT
IONIS PHARMACEUTICALS INC
2005
AGREEMENT FOR PURCHASE AND SALE OF 2280 Faraday Avenue San Diego, CA 92008 June 28, 2005
Purchase Agreements
IONIS PHARMACEUTICALS INC
2005
SECURITIESPURCHASE AGREEMENT
IONIS PHARMACEUTICALS INC
2004
SUBCONTRACT AGREEMENT Time and Material / Labor Hour
IONIS PHARMACEUTICALS INC
Biotechnology
2004
OMBApp-al 2700-0042
IONIS PHARMACEUTICALS INC
2004