IONIS PHARMACEUTICALS INC Business Finance Contracts & Agreements

First Amendment dated June 15, 2023 to the Purchase and Sale Agreement by and between the Registrant and Oxford I Asset Management USA Inc. dated as of October 20, 2022 (Filed With SEC on August 9, 2023)

Indenture, dated as of June 12, 2023, by and between the Company and U.S. Bank Trust Company, National Association, as Trustee (Filed With SEC on June 12, 2023)

Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement for Restricted Stock Units granted under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002... (Filed With SEC on May 3, 2023)

Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors Stock Option Plan, as amended on March 14, 2023 (Filed With SEC on May 3, 2023)

Form of Option Agreement for Options granted under the Ionis Pharmaceuticals, Inc. Amended and Restated 2002 Non-Employee Directors Stock Option Plan (Filed With SEC on February 22, 2023)

Form of Warrant Confirmation (Filed With SEC on April 13, 2021)

Form of Convertible Note Hedge Confirmation (Filed With SEC on April 13, 2021)

Indenture, dated as of April 12, 2021, by and between the Company and U.S. Bank National Association, as Trustee (Filed With SEC on April 13, 2021)

Indenture, dated as of December 19, 2019, by and between Ionis Pharmaceuticals, Inc. and U.S. Bank National Association, as trustee (Filed With SEC on December 23, 2019)

Consent to Collateral Addition and Amendment to Loan Documents between the Registrant, Ionis Gazelle, LLC, Wells Fargo Bank, National Association, as Trustee for the Benefit of... (Filed With SEC on November 6, 2019)

Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan (Filed With SEC on March 26, 2019)

STOCK PURCHASE AGREEMENT (Filed With SEC on May 9, 2017)

AMENDMENT NO. 2 TO LINE OF CREDIT AGREEMENT (Filed With SEC on February 26, 2016)

Amendment No.1 to Loan Documents between Ionis Pharmaceuticals, Inc. and Morgan Stanley Private Bank, National Association dated December 30, 2015 (Filed With SEC on January 5, 2016)

ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of November 17, 2014 1.00% Convertible Senior Notes due 2021 (Filed With SEC on November 21, 2014)

Isis Pharmaceuticals, Inc. 9,000,000 shares of common stock, par value $0.001 per share Underwriting Agreement (Filed With SEC on May 9, 2013)

ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of August 13, 2012 2.75% Convertible Senior Notes due 2019 (Filed With SEC on August 13, 2012)

ISIS PHARMACEUTICALS, INC. RESTRICTED STOCK UNIT GRANT NOTICE (AMENDED & RESTATED 2002 NON-EMPLOYEE DIRECTORS STOCK OPTION PLAN) (Filed With SEC on August 6, 2012)

THIRD AMENDMENT TO LOAN AGREEMENT (Filed With SEC on August 6, 2012)

SECOND AMENDMENT TO LOAN AGREEMENT (Filed With SEC on March 1, 2011)

AMENDMENT NUMBER ONE TO THE FOUNDING INVESTOR RIGHTS AGREEMENT (Filed With SEC on August 9, 2010)

FIRST AMENDMENT TO LOAN AGREEMENT (Filed With SEC on March 1, 2010)

STOCK PURCHASE AGREEMENT by and among IBIS BIOSCIENCES, INC., ISIS PHARMACEUTICALS, INC. and ABBOTT MOLECULAR INC. Dated: December 17, 2008 (Filed With SEC on February 26, 2009)

LOAN AGREEMENT (Filed With SEC on February 26, 2009)

$125,000,000 ISISPHARMACEUTICALS, INC. 2 58%Convertible Subordinated Notes due 2027 PURCHASEAGREEMENT (Filed With SEC on January 24, 2007)

ISISPHARMACEUTICALS, INC. WARRANTTO PURCHASE COMMON STOCK (Filed With SEC on May 10, 2006)

AGREEMENT FOR PURCHASE AND SALE OF 2280 Faraday Avenue San Diego, CA 92008 June 28, 2005 (Filed With SEC on August 9, 2005)