ALNYLAM PHARMACEUTICALS, INC. Contracts & Agreements

209 Contracts & Agreements
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Filed
Form of Restricted Stock Unit Award Agreement for Non-employee Directors under the Amended and Restated 2018 Stock Incentive Plan, as amended
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2025
Forms of Performance Stock Unit Award Agreements under the Amended and Restated 2018 Stock Incentive Plan, as amended
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2025
Amendment No. 3 entered into as of August 1, 2024 to the Master Collaboration Agreement dated as of April 8, 2019 by and between the Registrant and Regeneron Pharmaceuticals, Inc
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Form of Performance Stock Unit Award Agreement for Executive Officers under 2018 Stock Incentive Plan, as amended (granted on or after June 11, 2024)
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Form of Restricted Stock Unit Award Agreement for Executive Officers under 2018 Stock Incentive Plan, as amended (granted on or after June 11, 2024)
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Form of Nonstatutory Stock Option Agreement for Executive Officers under 2018 Stock Incentive Plan, as amended (granted on or after June 11, 2024)
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Form of Nonstatutory Stock Option Agreement for Non-Employee Directors under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Amendment No
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Letter Agreement, effective as of March 1, 2024, between the Company and Indrani L. Franchini
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2024
Amendment No. 1 entered into as
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2023
Letter Agreement, dated July 31, 2023, between Alnylam Pharmaceuticals, Inc. and Akshay K. Vaishnaw, M.D., Ph.D
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2023
Form of Performance Stock Unit Award Agreement for Executive Officers under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2023
Form of Restricted Stock Unit Award Agreement for Executive Officers under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2023
Cross-License Agreement dated as of November 12, 2012 by and among the Registrant, Arbutus Biopharma Corporation (formerly Tekmira Pharmaceuticals Corporation) and Protiva...
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2023
License and Collaboration Agreement dated as of February 3, 2013 by and among The Medicines Company and the Registrant
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2023
Amendment No. 2 to License and Collaboration Agreement, dated as of October 31, 2022 between the Registrant and The Medicines Company
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2023
Amendment to Purchase and Sale Agreement dated October 31, 2022 between BX Bodyguard Royalties L.P. and the Registrant
Purchase Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2023
Indenture, dated as of September 15, 2022, between the Registrant
Indenture Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2022
Indenture, dated as of September 15, 2022, between Alnylam Pharmaceuticals, Inc. and The Bank of New York Mellon, as trustee
Indenture Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2022
Form of Capped Call Transaction Confirmation
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2022
Amended and Restated 2018 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2022
Letter Agreement between the Registrant and
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2022
Forms of Nonstatutory Stock Option Agreements under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2022
Forms of Stock Unit Award Agreements under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2022
Amendment No. 1 to Co-Development Agreement between the Registrant and BXLS V Bodyguard PCP L.P. and BXLS Family Investment Partnership V ESC L.P. dated November 23, 2021
Investment Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2022
Employment Agreement, dated December 14, 2021, between Alnylam Pharmaceuticals, Inc. and Dr. Yvonne L. Greenstreet
Employment Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2021
Letter Agreement between the Registrant and Laurie B. Keating dated September 6, 2021
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Letter Agreement effective as of October 26, 2021 between the Company and John M. Maraganore, Ph.D
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Second Amendment to Lease entered into as of April 28, 2021 by and between BMR-Fresh Pond Research Park LLC and the Registrant
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Sponsored Research Agreement dated as of July 27, 2009 by and among the
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Amendment No. 1 to Sponsored Research Agreement dated as of July 27, 2009
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Supplemental Agreement effective July 27, 2009 by and among the
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Employment Agreement effective as of August 2, 2021 between the Company and John M. Maraganore, Ph.D
Employment Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2021
Amended and Restated Annual Incentive Program, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2021
Change in Control Agreement dated November 2, 2020 by and between the Registrant and John M. Maraganore
Change of Control Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2021
Co-Development Agreement between the Registrant and BXLS
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2020
First Amendment to
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2020
First Amendment to Lease entered into between the Registrant and RREEF America REIT II CORP. PPP dated September 30, 2020
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2020
Letter Agreement between the Registrant and Barry E. Greene dated August 26, 2020
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2020
Patent Cross-License Agreement dated April 3, 2020 between Dicerna Pharmaceuticals, Inc. and the Registrant
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2020
Purchase and Sale Agreement dated April 10, 2020 between BX Bodyguard Royalties L.P. and the Registrant
Purchase Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2020
Description of Capital Stock
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2020
Amended and Restated Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2020
Amendment to License and Collaboration Agreement, dated as of November 22, 2019 between the Registrant and The Medicines Company
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2020
2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2019
Form of Ex-US Restricted/Performance Stock Unit Award Agreement under 2018 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2019
Amendment No. 3 entered into as of April 8, 2019 to the Master Collaboration Agreement dated as of January 11, 2014, as amended by Amendment No. 1 and Amendment No. 2, including...
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2019
Stock Purchase Agreement dated as of April 8, 2019 by and between the Registrant and Regeneron Pharmaceuticals, Inc
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2019
Investor Agreement dated as of April 8, 2019 by and between the Registrant and Regeneron Pharmaceuticals, Inc
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2019
Amended and Restated ALN-AT3 Global License Terms entered into as of April 8, 2019 by and between the Registrant and Genzyme Corporation
License Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2019
Amended and Restated Investor Agreement dated as of April 8, 2019 by and between the Registrant and Genzyme Corporation
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2019
Amended and Restated 2004 Employee Stock Purchase Plan, as amended
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2019
Underwriting Agreement, dated January 14, 2019, between Alnylam Pharmaceuticals, Inc. and Barclays Capital Inc
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2019
Sixth Amendment to Lease, dated August 14, 2018, by and between the Registrant and ARE-MA Region No. 28, LLC
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
Second Amendment to Lease, dated September 27, 2018, by and between Registrant and RREEF America REIT II CORP. PPP
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
2018 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2018
Forms of Incentive Stock Option Agreement, Nonstatutory Stock Option Agreements, Restricted Stock Agreement and Restricted Stock Unit Award Agreement under 2018 Stock Incentive...
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2018
Amendment No. 2 entered into as of January 6, 2018 to the Master Collaboration Agreement dated as of January 11, 2014, as amended by Amendment No. 1, including certain Regional,...
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
Exclusive License Agreement entered into as of January 6, 2018 by and between the Registrant and Genzyme Corporation
License Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
ALN-AT3 Global License Terms entered into as of January 6, 2018 by and between the Registrant and Genzyme Corporation
License Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
Manufacturing Services Agreement effective as of March 28, 2018 by and between the Registrant and Agilent Technologies, Inc
Services Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2018
Underwriting Agreement, dated November 13, 2017, by and among Alnylam Pharmaceuticals, Inc., Goldman Sachs & Co. LLC and J.P. Morgan Securities LLC, as representatives of the...
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2017
Form of Change in Control Agreement
Change of Control Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2017
ALNYLAM PHARMACEUTICALS, INC. SECOND AMENDED AND RESTATED 2009 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2017
ALNYLAM PHARMACEUTICALS, INC. Incentive Stock Option Agreement Granted Under Second Amended and Restated 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2017
ALNYLAM PHARMACEUTICALS, INC. AMENDED AND RESTATED 2004 EMPLOYEE STOCK PURCHASE PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2017
300 Third Street Cambridge MA, 02142 main ###-###-#### fax ###-###-####
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2017
ALNYLAMPHARMACEUTICALS, INC. 5,000,000 Shares of Common Stock Underwriting Agreement
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2017
300 Third StreetCambridge MA, 02142main 617.551.8200fax ###-###-####
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2017
ALNYLAM PHARMACEUTICALS, INC. Form of Nonstatutory Stock OptionAgreement Non-Plan Inducement Grant
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2016
FIRST AMENDMENT TO LEASE
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2016
FORM OF DIRECTOR INDEMNIFICATION AGREEMENT
Indemnification Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2016
CREDIT AGREEMENT Dated asof April 29, 2016 Among ALNYLAM U.S., INC., as theBorrower, ALNYLAM PHARMACEUTICALS, INC., as Parent and Parent Guarantor, and BANK OF AMERICA,N.A., as...
Credit Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2016
CREDIT AGREEMENT Dated asof April 29, 2016 Among ALNYLAM U.S., INC., as the Borrower, ALNYLAMPHARMACEUTICALS, INC., as Parent and Parent Guarantor, and WELLS FARGO BANK,NATIONAL...
Credit Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2016
Alnylam Pharmaceuticals, Inc. 2016 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2016
ALNYLAM PHARMACEUTICALS, INC. AMENDED AND RESTATED 2009 STOCK INCENTIVE PLAN (including amendment through March 2, 2016)
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2016
PURCHASE AND SALE AGREEMENT
Purchase Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2016
300 ThirdStreet Cambridge MA, 02142 main ###-###-#### fax ###-###-####
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2016
AMENDMENT NO. 1 TO MASTER COLLABORATION AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
AMENDMENTNUMBER ONE TO THE SECOND AMENDED AND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
AMENDED AND RESTATED DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT
Development Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
CONFIDENTIAL SETTLEMENT AGREEMENT AND MUTUAL RELEASE
Settlement Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
EXCLUSIVE LICENSE AGREEMENT FOR TUSCHL II UNITED STATES PATENTS AND PATENT APPLICATIONS
License Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
ALNYLAM PHARMACEUTICALS, INC. AMENDED AND RESTATED 2009 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2015
ALNYLAM PHARMACEUTICALS, INC. Incentive Stock Option Agreement Granted Under Amended and Restated 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2015
ALNYLAM PHARMACEUTICALS, INC. Restricted Stock Agreement
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2015
ALNYLAM PHARMACEUTICALS, INC. Nonstatutory Stock Option Agreement Granted Under Amended and Restated 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
LEASE RREEF AMERICA REIT IICORP. PPP, Landlord, and ALNYLAM PHARMACEUTICALS,INC., Tenant RiverfrontOffice Park Cambridge, Massachusetts TABLE OF CONTENTS (continued)
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
LEASE RREEF AMERICA REIT IICORP. PPP, Landlord, and ALNYLAM PHARMACEUTICALS,INC., Tenant RiverfrontOffice Park Cambridge, Massachusetts TABLE OF CONTENTS (continued)
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
LEASE by and between BMR-675 WEST KENDALL STREET LLC, a Delaware limited liability company and ALNYLAMPHARMACEUTICALS, INC., a Delaware corporation Table of Contents
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2015
CERTIFICATE OF ELIMINATION OF THE SERIES A JUNIOR PARTICIPATING PREFERRED STOCK OF ALNYLAM PHARMACEUTICALS, INC. Pursuant to Section 151(g) of the General Corporation Law ofthe...
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
Alnylam Pharmaceuticals, Inc. 2015 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
SECOND AMENDEDAND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2015
AMENDMENT TO THE RESEARCH COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2015
ALNYLAMPHARMACEUTICALS, INC. 4,736,842 Shares of Common Stock Underwriting Agreement
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2015
LETTER AGREEMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
ALNYLAM PHARMACEUTICALS, INC. AMENDED AND RESTATED 2004 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
ALNYLAM PHARMACEUTICALS, INC. Incentive Stock Option Agreement Granted Under Amended and Restated 2004 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
ALNYLAM PHARMACEUTICALS, INC. 2009 STOCK INCENTIVE PLAN, AS AMENDED
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
ALNYLAM PHARMACEUTICALS, INC. Incentive Stock Option Agreement Granted Under 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
ALNYLAM PHARMACEUTICALS, INC. Restricted Stock Agreement
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
ALNYLAM PHARMACEUTICALS, INC. Nonstatutory Stock Option Agreement Granted Under 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
STOCK PURCHASE AGREEMENT by and among ALNYLAMPHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC., MERCK SHARP & DOHME CORP., and solely for purposes of Sections 3.19, 5.2, 5.6,...
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
Alnylam Pharmaceuticals, Inc. 2014 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
STOCK PURCHASE AGREEMENT By and Between GENZYMECORPORATION AND ALNYLAM PHARMACEUTICALS, INC. Dated as of January 11, 2014 TABLE OF CONTENTS
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
INVESTOR AGREEMENT BYAND BETWEEN GENZYME CORPORATION AND ALNYLAMPHARMACEUTICALS, INC. DATED AS OF FEBRUARY 27, 2014
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2014
FIRST AMENDMENT TO RIGHTS AGREEMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2014
MASTER SERVICES AGREEMENT Between Medpace, Inc. an Ohio Corporation 4620 WesleyAvenue Cincinnati, Ohio 45212 (MEDPACE) and Alnylam Pharmaceuticals, Inc. 300Third Street Cambridge,...
Services Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2014
ALNYLAM PHARMACEUTICALS, INC. 2009 STOCK INCENTIVE PLAN, AS AMENDED
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2013
Alnylam Pharmaceuticals, Inc. 2013 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2013
LICENSE AND COLLABORATION AGREEMENT by and between ALNYLAM PHARMACEUTICALS, INC. and THE MEDICINES COMPANY
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2013
CONSULTING AGREEMENT
Consulting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2013
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions.
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2013
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions.
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2013
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2013
65 Hayden Avenue, Lexington, MA 02421 P ###-###-#### F ###-###-#### www.cubist.com
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2013
ALNYLAM PHARMACEUTICALS, INC. 8,000,000 Shares of Common Stock Underwriting Agreement
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2013
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. LICENSE AND COLLABORATION AGREEMENT
Exchange Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2012
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions.
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2012
[Signature Page follows]
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2012
Alnylam Pharmaceuticals, Inc. 2012 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2012
Confidential Materials omitted and filed separately with the Securities andExchange Commission. Asterisks denote omissions. LEASE by and between BMR-FRESH POND RESEARCH PARK LLC,...
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2012
CONSULTING AGREEMENT
Consulting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2012
ALNYLAM PHARMACEUTICALS, INC. 7,500,000 Shares of Common Stock Underwriting Agreement
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2012
FOURTH AMENDMENT TO LEASE
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2012
SUBLEASE
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2012
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions.
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. Alnylam Tekmira Protiva UBC AlCana Supplemental...
Exchange Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2011
EX-101 INSTANCE DOCUMENT
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2011
EX-10.2 Third Amendment to Lease, dated May 11, 2010
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2010
EX-10.9 Forms of Incentive Stock Option Agreement and Nonstatutory Stock Option Agreement
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2010
EX-10.16 2010 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2010
EX-10.39 Collaboration Agreement entered into as of October 29, 2009
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2010
EX-10.40 First Amendment to License and Collaboration Agreement entered into as of November 2, 2009
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2010
EX-10.1 Letter Agreement between the Registrant and John A. Schmidt, Jr., M.D
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2009
Ex-10.1 Amended and Restated 2004 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2009
Ex-10.2 2009 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2009
Ex-10.3 Amended and Restated Strategic Collaboration and License Agreement effective as of April 28, 2009 between Isis Pharmaceuticals, Inc. and the Registrant
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2009
Ex-10.4 Second Amendment to Lease, dated June 26, 2009, by and between the Registrant and ARE-MA Region No. 28, LLC
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2009
Ex-10.1 2009 Annual Incentive Program
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2009
Ex-10.2 License and Collaboration Agreement between the Registrant and Cubist
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2009
Ex-10.23 Research Collaboration and License Agreement
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2009
Ex-10.26 License and Collaboration Agreement
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2009
EX-10.3 2004 Stock Incentive Plan, as amended
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2008
EX-10.8 2004 Employee stock Purchase Plan, as amended
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2008
Ex-10.1 License and Collaboration Agreement, entered into as of July 8, 2007, by and among F. Hoffmann-La Roche, Ltd, Hoffman-La Roche Inc., the Registrant and, for limited...
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2007
Ex-10.2 Common Stock Purchase Agreement dated as of July 8, 2007 between the Registrant and Roche Finance Ltd
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2007
Ex-10.3 Share Purchase Agreement, dated as of July 8, 2007, among Alnylam Europe AG, the Registrant and Roche Pharmaceuticals GmbH
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2007
Ex-10.4 Amended and Restated Collaboration Agreement, entered into as of July 27, 2007, by and between the Registrant and Medtronic, Inc
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2007
Ex-10.5 License and Collaboration Agreement, entered into as of September 6, 2007, by and among the Registrant, Isis Pharmaceuticals, Inc. and Regulus Therapeutics LLC
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2007
Ex-10.6 Limited Liability Company Agreement of Regulus Therapeutics LLC, dated as of September 6, 2007
Limited Liability Company Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2007
Ex-10.7 Termination Agreement, dated as of September 18, 2007, by and between Merck & Co., Inc. and the Registrant
Termination Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2007
EX-1.1 Underwriting Agreement, dated December 12, 2006
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2006
Ex-10.1 Collaboration and License Agreement by and between the Registrant and Biogen Idec MA. Inc. dated September 20, 2006
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2006
Ex-10.2 Letter Agreement by and between the Registrant and Vincent J. Miles effective as of October 20, 2006
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2006
EX-10.1 AMEND. & RESTATED RESEARCH COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2006
EX-10.2 TERMINATION AGREEMENT
Termination Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2006
EX-10.3 AMENDMENT NO. 2 TO ADDENDUM RE: INFLUENZA PROGRAM
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2006
Ex-10.1 Master Security Agreement
Security Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
VA
2006
EX-10.1 First Amendment to Lease, effective as of March 16, 2006
Lease Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2006
Ex-10.39 Amendment No. 1 to Addendum
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2006
EX-10.1 RESEARCH COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2005
EX-10.1 STOCK PURCHASE AGREEMENT
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2005
EX-10.2 INVESTOR RIGHTS AGREEMENT
Investor Rights Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.3 RESEARCH COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2005
EX-10.3 Forms of Incentive Stock Option
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.6 Amendment No. 1 to dated August 2,2004
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.8 Agreement Garching Innovation GmbH
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
Ex-4.1 Rights Agreement
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2005
EX-10.1 - Form of Nonstatutory Stock Option Agreement
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.2 - Form of Restricted Stock Agreement
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2005
Ex-10.1 Amendment No. 02 to Loan and Security Agreement
Loan Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.1 SUMMARY OF CASH COMPENSATION FOR DIRECTORS
Compensation Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
EX-10.2 2004 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2005
Ex-10.1 Collaboration Agreement effective as of February 8, 2005
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2005
Ex-10.6 Summary of Cash Compensation Paid to Directors
Compensation Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2005
Ex-10.1 Form of Nonstatutory Stock Option Agreement
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004
EX-1.1 Amendment to Underwriting Agreement
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004
EX-10.1 COLLABORATION AND LICENSE AGREEMENT
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2004
EX-1.1 UNDERWRITING AGREEMENT
Underwriting Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
NY
2004
EX-4.1 SPECIMEN CERTIFICATE
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004
EX-10.1 2002 EMP, DIRECTOR & CONSULTANT STOCK PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2004
EX-10.2 2003 EMP, DIRECTOR & CONSULTANT STOCK PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
MA
2004
EX-10.3 2004 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.4 2004 EMPLOYEE STOCK PURCHASE PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
Ex-4.1 Specimen Certificate evidencing shares
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004
Ex-10.2 2003 Stock Plan, as amended
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
Ex-10.3 2004 Stock Incentive Plan
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
Ex-10.19 Co-exclusive License Agreement
License Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004
Ex-10.26 Agreement with Perini Building Company
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
WA
2004
EX-10.1 2002 EMPLOYEE, DIRECTOR STOCK PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.2 2003 EMPLOYEE, DIRECTOR STOCK PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.3 2004 STOCK INCENTIVE PLAN
Bonus & Incentive Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.4 2004 EMPLOYEE STOCK PURCHASE PLAN
Stock Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.11 LOAN AND SECURITY AGREEMENT
Loan Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
CA
2004
EX-10.12 WARRANT TO PURCHASE PREFERRED STOCK
Warrant Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.24 STRATEGIC COLLABORATION & LICENSE
Collaboration Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
DE
2004
EX-10.25 INVESTOR RIGHTS AGREEMENT
Investor Rights Agreements
ALNYLAM PHARMACEUTICALS, INC.
Biotechnology
2004