Notice of Assignment of Lease, dated January 1, 2022 from 5

2000 Main Holdings Inc. and Mount Pixel Projects Limited Partnership (together, the
"Interim Owner"); and

RE:    Lease dated for reference January 25, 2019, as amended and modified from time to time (collectively, the "Lease"), between the Assignor, as landlord, and the Tenant, as tenant, the Assignor leased to the Tenant certain premises comprising a portion of the second
floor and the fifth, sixth, seventh and eighth floors of the building situate at 114 East 4th Avenue, Vancouver, British Columbia and legally described as Parcel Identifier: 030-712
181, Lot A Block 24 District Lot 200A Group 1 New Westminster District Plan EPP83574
(the "Property")

1.Effective as of the date of this Notice, the Assignor transferred (the "First Transfer") to the
Interim Owner, all of the Assignor's beneficial right, title and interest in and to the Property,
each as to an undivided 50% interest.

2.In connection with the First Transfer, the Assignor transferred to the Interim Owner all of the
Assignor's right, title and interest in and to the Lease. A copy of the assignment agreement is
attached hereto as Schedule A.

3.Effective as of the date hereof, the Interim Owner transferred (the "Second Transfer") to the
Assignee, all of the Interim Owner's beneficial right, title and interest in and to the Property.

4.In connection with the Second Transfer, the Interim Owner transferred to the Assignee all of
the Interim Owner's right, title and interest in and to the Lease. A copy of the assignment
agreement is attached hereto as Schedule B.

5.The Assignee has accepted the assignment of the Lease and all of the right, title, interest, obligations, duties and liabilities of the landlord arising under the Lease from and after the effective date of the assignment, and covenants and agrees with the Tenant to perform any
such obligations and duties and discharge such liabilities in accordance with the provisions of the Lease.

6.From and after the date of this Notice, the Assignee is entitled to: (i) receive all rents and other
payments due under your lease; and (ii) be named as your landlord in any insurance policy

7.    Until further written notice from the Assignee, you are hereby authorized and directed to
make all rent and other payments falling due under your lease from and after the date hereof
payable to "130 E 4th Partnership”, or as the Assignee may in writing further direct, at the
address set out below:

This Notice may be executed by electronic signatures and delivered by electronic means. Such
electronic copy will be deemed an original and may be used as evidence of execution.

by its general partner, 1038324 B.C. LTD.

by its general partner, 1038324 B.C. LTD.

The Tenant hereby acknowledges receipt of this Notice and covenants to perform and observe
all of the obligations of the Tenant as set out in the Lease or established at law arising during the
term of the Lease and any renewal or extension thereof including, without limiting the generality
of the foregoing, the obligation to pay rent and all other amounts payable under the Lease by the Tenant to the Assignee, now owing or to become due in the future and whether characterized as
rent or not, and all other obligations of the Tenant whether constituting conditions, covenants,
provisos, representations, undertakings or warranties.

Acknowledged this 14th day of February, 2022. ZYMEWORKS INC.