Zymeworks Inc. | Business Contracts

Open Market Sale AgreementSM, dated October 21, 2022, by and between Zymeworks Inc. and Jefferies LLC (Filed With SEC on October 21, 2022)

Restated and Amended Transaction Agreement, dated August 18, 2022, by and among Zymeworks, Parent, Callco, and ExchangeCo (Filed With SEC on August 19, 2022)

Employment Agreement by and between the Company, Zymeworks Biopharmaceuticals Inc. and Paul Moore, dated July 18, 2022 (Filed With SEC on August 4, 2022)

Third Amendment to Collaboration and Cross License Agreement, effective June 6, 2022, by and between the Company and Daiichi Sankyo Co., Ltd (Filed With SEC on August 4, 2022)

Notice of Assignment of Lease, dated January 1, 2022 from 5 (Filed With SEC on August 4, 2022)

Lease Amending Agreement, dated April 1, 2022, by and between the Company and 130 E 4th Partnership (Filed With SEC on August 4, 2022)

Transaction Agreement, dated July 14, 2022, by and among Zymeworks, Parent, Callco, and ExchangeCo (Filed With SEC on July 15, 2022)

Resolutions of the Board of Directors of Zymeworks, Inc. (incorporated by reference to Exhibit A of Exhibit 4.1 hereto) (Filed With SEC on June 10, 2022)

Zymeworks Inc. Executive Incentive Compensation Plan (Filed With SEC on March 9, 2022)

Amended and Restated Employment Agreement by and between the Company and Christopher Astle, effective February 24, 2022 (Filed With SEC on February 25, 2022)

Letter, dated November 9, 2021, from the (Filed With SEC on February 24, 2022)

Separation and Release Agreement by and between the Company and James Priour, dated (Filed With SEC on February 24, 2022)

Specimen common share certificate (Filed With SEC on February 24, 2022)

Form of Pre-Funded Warrant to Purchase Common Shares (Filed With SEC on January 27, 2022)

Underwriting Agreement dated January 26, 2022 (Filed With SEC on January 27, 2022)

Promotion Letter from the Company to Neil Klompas, dated January 5, 2022 (Filed With SEC on January 5, 2022)

Zymeworks Inc. Inducement Stock Option and Equity Compensation Plan (Filed With SEC on January 5, 2022)

Separation Agreement and Release by and between the Company and Ali Tehrani, dated January 5, 2022 (Filed With SEC on January 5, 2022)

Employment Agreement by and between the Company and Kenneth Galbraith, dated January 5, 2022 (Filed With SEC on January 5, 2022)

Amendment No. 1 to the Open Market Sale AgreementSM, dated October 1, 2021, by and between Zymeworks Inc. and Jefferies LLC (Filed With SEC on October 1, 2021)

Letter, dated May 16, 2021, from the Registrant to Neil Josephson (Filed With SEC on August 4, 2021)

Employment Agreement, effective April 29, 2019, by and between the Registrant and Neil Josephson (Filed With SEC on August 4, 2021)

Letter, dated March 3, 2021, from the Registrant to James Priour (Filed With SEC on May 5, 2021)

Employment Agreement, effective April 1, 2020, by and between the Registrant and James Priour (Filed With SEC on May 5, 2021)

First Amendment to Collaboration Agreement, dated May 25, 2020, by and between Zymeworks Inc. and BeiGene, Ltd (Filed With SEC on August 5, 2020)

Third Amendment to Collaboration Agreement, dated June 22, 2020, by and between Zymeworks Inc., Celgene Corporation and Celgene Alpine Investment Co. LLC (Filed With SEC on August 5, 2020)

Zymeworks Amended and Restated Stock Option and Equity Compensation Plan (Filed With SEC on May 7, 2020)

Registration Rights Agreement dated March 16, 2020, by and among Zymeworks Inc., Baker Brothers Life Sciences, L.P. and 667, L.P (Filed With SEC on March 16, 2020)

Employment Agreement effective October 14, 2019, by and between the Registrant and Kathryn ODriscoll (Filed With SEC on March 2, 2020)

Description of Capital Stock (Filed With SEC on March 2, 2020)

Form of Pre-Funded Warrant to Purchase Common Shares (Filed With SEC on January 24, 2020)

Underwriting Agreement dated January 22, 2020 (Filed With SEC on January 24, 2020)

Open Market Sale AgreementSM, dated November 5, 2019, between Zymeworks Inc. and Jefferies LLC (Filed With SEC on November 6, 2019)

Employment Agreement effective September 17, 2018, by and between the Registrant and Anthony Polverino (Filed With SEC on March 6, 2019)

Indenture of Lease dated as of January 25, 2019, by and between 5th & Main Partnership and Zymeworks Inc (Filed With SEC on March 6, 2019)

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