Sierra Oncology, Inc. Contracts & Agreements

Loan and Security Agreement dated January 21, 2022 by and between the Company and Oxford Finance LLC (Filed With SEC on May 6, 2022)

Agreement and Plan of Merger, dated April 12, 2022, between GlaxoSmithKline plc, Orikum Acquisition Inc., and Sierra Oncology, Inc (Filed With SEC on April 13, 2022)

Form of Support Agreement, dated as of April 12, 2022, by and among GlaxoSmithKline plc, Orikum Acquisition Inc., Sierra Oncology, Inc, and certain securityholders of Sierra... (Filed With SEC on April 13, 2022)

Transition Agreement and Release dated March 22, 2022 between the Company and Mark Kowalski (Filed With SEC on March 23, 2022)

Consulting Agreement dated March 22, 2022 between the Company and Mark Kowalski (Filed With SEC on March 23, 2022)

Description of Securities (Filed With SEC on March 10, 2022)

2018 Equity Inducement Plan, as amended, and forms of award agreements thereunder (Filed With SEC on March 10, 2022)

Underwriting Agreement, dated as of January 26, 2022 (Filed With SEC on January 27, 2022)

Form of Prefunded Warrant (Filed With SEC on January 27, 2022)

License Agreement dated August 3, 2021 by and between the Registrant and AstraZeneca AB (Filed With SEC on November 5, 2021)

Form of Amendment No. 1 to the Series A Warrant to Purchase Common Stock (Filed With SEC on September 13, 2021)

Form of Amendment No. 1 to the Series B Warrant to Purchase Common Stock (Filed With SEC on September 13, 2021)

2015 Equity Incentive Plan, as amended, and forms of award agreements thereunder (Filed With SEC on March 11, 2021)

2018 Equity Inducement Plan, as amended, and forms of award agreements thereunder (Filed With SEC on March 11, 2021)

Amendment No. 1 to the License Agreement dated November 10, 2020 by and between the Registrant and CRT Pioneer Fund LP (Filed With SEC on March 11, 2021)

Office Sublease, dated December 1, 2020, by and between Sierra Oncology Canada ULC and Scougall Management (1987) Limited and consented to on December 18, 2020 by Van885 West... (Filed With SEC on March 11, 2021)

Office Lease, dated December 10, 2020 and effective December 14, 2020, by and between Sierra Oncology, Inc. and KW Fund VI-San Mateo, LLC (Filed With SEC on March 11, 2021)

Form of Employment Agreement between the Registrant and Stephen G. Dilly (Filed With SEC on August 6, 2020)

Separation Agreement dated May 28, 2020 between the Registrant and Nick Glover (Filed With SEC on August 6, 2020)

2018 Equity Inducement Plan, as amended, and forms of award agreements thereunder (Filed With SEC on August 6, 2020)

Amendment to Asset Purchase Agreement dated October 28, 2019, by and between the Registrant and YM Biosciences Australia Pty Ltd. and Gilead Sciences, Inc (Filed With SEC on March 3, 2020)

Description of Securities (Filed With SEC on March 3, 2020)

2015 Equity Incentive Plan, as amended, and forms of award agreements thereunder (Filed With SEC on March 3, 2020)

Securities Purchase Agreement, dated January 31, 2020, by and between the Company and Gilead Sciences, Inc (Filed With SEC on February 6, 2020)

Gilead Warrant, dated January 31, 2020 (Filed With SEC on February 6, 2020)

Form of Series A Convertible Voting Preferred Stock Certificate (Filed With SEC on November 13, 2019)

Underwriting Agreement, dated November 7, 2019 (Filed With SEC on November 7, 2019)

Form of Series A Warrant (Filed With SEC on November 7, 2019)

Form of Series B Warrant (Filed With SEC on November 7, 2019)

Asset Purchase Agreement dated August 20, 2018 by and between the Registrant and YM Biosciences Australia Pty Ltd, and Gilead Sciences, Inc (Filed With SEC on November 8, 2018)

Warrant dated August 21, 2018 issued to Silicon Valley Bank (Filed With SEC on November 8, 2018)

Loan and Security Agreement dated August 21, 2018, by and between the Registrant and Silicon Valley Bank (Filed With SEC on November 8, 2018)

2018 Equity Inducement Plan and forms of award agreements thereunder (Filed With SEC on November 8, 2018)

Underwriting Agreement dated March 2, 2018 (Filed With SEC on March 2, 2018)

Office Lease, dated June 12, 2017, by and between Sierra Oncology Canada ULC and The Cadillac Fairview Corporation Limited, as the duly authorized agent of Ontrea Inc. and Van885... (Filed With SEC on August 10, 2017)

AMENDMENTTO EMPLOYMENT AGREEMENT (Filed With SEC on May 9, 2017)

19,500,000 Shares Sierra Oncology, Inc. UNDERWRITING AGREEMENT (Filed With SEC on February 9, 2017)

DATED 27TH SEPTEMBER 2016 (Filed With SEC on November 10, 2016)

LICENSE AGREEMENT (Filed With SEC on August 12, 2016)

STANDARD OFFICE LEASE (Filed With SEC on March 3, 2016)

[] Shares ProNAi Therapeutics, Inc. UNDERWRITING AGREEMENT (Filed With SEC on July 6, 2015)

Additional abbreviationsmay also be used though not in the above list. (Filed With SEC on July 6, 2015)

PRONAI THERAPEUTICS, INC. 2015 EQUITY INCENTIVE PLAN (Filed With SEC on July 6, 2015)

PRONAI THERAPEUTICS, INC. 2015 EMPLOYEE STOCK PURCHASE PLAN (Filed With SEC on July 6, 2015)

PRONAI THERAPEUTICS INC. EMPLOYMENT AGREEMENT (Filed With SEC on July 6, 2015)

PRONAI THERAPEUTICS CANADA ULC EMPLOYMENT AGREEMENT (Filed With SEC on July 6, 2015)

PRONAI THERAPEUTICS, INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT TABLE OF CONTENTS (Filed With SEC on June 12, 2015)

INDEMNITY AGREEMENT (Filed With SEC on June 12, 2015)

PRONAI THERAPEUTICS, INC. 2008 STOCK PLAN (Filed With SEC on June 12, 2015)

SEPARATION AND RELEASE AGREEMENT (Filed With SEC on June 12, 2015)

MICHIGAN LIFE SCIENCE AND INNOVATION CENTER LEASE (Filed With SEC on June 12, 2015)

SUBLEASE (Filed With SEC on June 12, 2015)

EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on June 12, 2015)

SECOND LICENSE AMENDMENT AND CONSENT TO TERMINATION (Filed With SEC on June 12, 2015)

LICENSE PAYMENT AGREEMENT (Filed With SEC on June 12, 2015)