Amended Employment Offer Letter by and between La Jolla Pharmaceutical Company and Larry Edwards

If La Jolla terminates your employment without Cause, or you terminate your employment for Good Reason within 12 months after a Change In Control Event (as defined in Attachment A), then: (1) you will receive as severance pay an amount equal to eighteen (18) months of your then­current base salary (subject to all applicable federal, state and local tax withholdings, and payable over a eighteen­month period in accordance with La Jolla's regular payroll practices); (2) you will receive 100% of your then­current annual Target Bonus (subject to all applicable federal, state and local taxes and withholdings and payable in a lump sum); and (3) La Jolla will pay your COBRA premiums for medical, dental and vision insurance for you, your spouse and covered dependents, provided that you are eligible for and elect COBRA coverage, until the earlier of: (i) eighteen (18) months after your employment ends; or (ii) the date that you become employed by a new employer.