HELICOS BIOSCIENCES CORP Contracts & Agreements

[Signature pages follow.] (Filed With SEC on August 29, 2012)

NON-EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on August 6, 2012)

ASSET PURCHASE AGREEMENT (Filed With SEC on April 10, 2012)

FIRST AMENDMENT TO SUBORDINATED SECURED NOTE PURCHASE AGREEMENT (Filed With SEC on December 1, 2011)

FIRST AMENDMENT TO LICENSE AGREEMENT Between Arizona Science and Technology Enterprises LLC, dba Arizona Technology Enterprises, ASU SkySong, 1475 N. Scottsdale Rd., Suite 200... (Filed With SEC on November 14, 2011)

SEVENTH AMENDMENT TO LEASE (Filed With SEC on September 22, 2011)

SUBORDINATED SECURED NOTE PURCHASE AGREEMENT (Filed With SEC on November 19, 2010)

RISK PREMIUM PAYMENT AGREEMENT (Filed With SEC on November 19, 2010)

WAIVER, CONSENT AND FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on November 19, 2010)

SIXTH AMENDMENT TO LEASE (Filed With SEC on June 14, 2010)

Helicos BioSciences Corporation 6,400,000 Shares Warrantsto Purchase 4,160,000 Shares CommonStock Underwriting Agreement (Filed With SEC on December 18, 2009)

HELICOS BIOSCIENCES CORPORATION WARRANT TO PURCHASE COMMON STOCK Warrant No. [ ] Original Issue Date: December [ ], 2009 (Filed With SEC on December 18, 2009)

FIFTH AMENDMENT TO LEASE (Filed With SEC on October 13, 2009)

[Remainder of Page Intentionally Left Blank] (Filed With SEC on September 28, 2009)

HELICOS BIOSCIENCES CORPORATION WARRANT TO PURCHASE COMMON STOCK (Filed With SEC on September 17, 2009)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on September 17, 2009)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on September 17, 2009)

ScheduleA WAIVER AND RELEASE AGREEMENT (Filed With SEC on August 11, 2009)

HELICOSBIOSCIENCES CORPORATION Change inControl Agreement (Filed With SEC on August 11, 2009)

HELICOSBIOSCIENCES CORPORATION Change inControl Agreement (Filed With SEC on January 30, 2009)

WAIVER AND THIRDAMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on December 30, 2008)

LOAN AND SECURITY AGREEMENT (Filed With SEC on December 30, 2008)

HELICOS BIOSCIENCES CORPORATION WARRANT TO PURCHASE COMMON STOCK Warrant No. Original Issue Date: December , 2008 (Filed With SEC on December 22, 2008)

SECURITIESPURCHASE AGREEMENT (Filed With SEC on December 22, 2008)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on December 22, 2008)

HELICOSBIOSCIENCES CORPORATION CORPORATEOFFICER SEVERANCE PLAN (Filed With SEC on December 17, 2008)

CONSULTANTAGREEMENT (Filed With SEC on December 8, 2008)

SEVERANCE AND CONSULTING SERVICES AGREEMENT (Filed With SEC on September 12, 2008)

/s/ Stephen J. Lombardi August 19, 2008 Stephen J. Lombardi Date (Filed With SEC on August 20, 2008)

HELICOSBIOSCIENCES CORPORATION Amendedand Restated Change in Control Agreement (Filed With SEC on August 20, 2008)

SECOND AMENDMENT TO LOANAND SECURITY AGREEMENT (Filed With SEC on June 30, 2008)

SAMPLE (Filed With SEC on June 30, 2008)

HELICOSBIOSCIENCES CORPORATION Change inControl Agreement (Filed With SEC on May 1, 2008)

HELICOS BIOSCIENCES CORPORATION Amended and Restated ManagementIncentive Bonus Plan as of March 13, 2008 (Filed With SEC on March 17, 2008)

LOAN AND SECURITY AGREEMENT (Filed With SEC on March 17, 2008)

HELICOSBIOSCIENCES CORPORATION Change inControl Agreement (Filed With SEC on August 10, 2007)

[HELICOS BIOSCIENCES LOGO] HELICOS BIOSCIENCES CORPORATION INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE (Filed With SEC on May 7, 2007)

HELICOS BIOSCIENCES CORPORATION Management Incentive Bonus Plan (Filed With SEC on May 7, 2007)

AMENDMENT TO AMENDED AND RESTATED INVESTOR RIGHTSAGREEMENT (Filed With SEC on May 7, 2007)

HELICOSBIOSCIENCES CORPORATION Change inControl Agreement (Filed With SEC on May 7, 2007)

Non-EmployeeDirector Compensation Policy (Filed With SEC on May 7, 2007)

Category

Industry

Companies

Contracts

HELICOS BIOSCIENCES CORP Contracts & Agreements