Second Amendment to Amended and Restated License Agreement between Exicure, Inc. and Northwestern University

Summary

This agreement is the second amendment to a prior license agreement between Exicure, Inc. and Northwestern University. It updates Appendix A of the original agreement, which likely lists licensed intellectual property, while confirming that all other terms remain unchanged. Both parties agree to these modifications, and the amendment is effective as of November 30, 2017. Confidential information has been omitted from the public version of this document.

EX-10.22 4 exicureexhibit1022123119.htm EXHIBIT 10.22 Exicure Exhibit 10.22 12/31/19

Exhibit 10.22



Innovation and	Northwestern University	Phone ###-###-####	Northwestern \|INVO
New Ventures Office	1800 Sherman Ave, Suite 504	invo.northwestern.edu	Innovation and New Ventures
	Evanston, IL 60201

November 30, 2017

David A Giljohann, Ph.D.

Chief Executive Officer

Exicure, Inc.

8045 Lamon Ave.

Skokie, IL 60077

Re: Amendment Two to the Amended Restated License Agreement effective December 12, 2011 between Exicure, Inc. ("Exicure") and Northwestern University ("Northwestern') (the "Agreement").

Dear David:

This letter agreement memorializes the understanding reached between Northwestern and Exicure regarding the Second Amendment to the Agreement ("Amendment Two). Unless otherwise defined In this Amendment Two, capitalized terms shall have the meaning assigned to them in the Agreement.

Subject to the terms and conditions of the Agreement and Exicure's compliance therewith, the parties hereby agree as follows:


1.	Appendix A of the Agreement is amended and incorporated herein by reference.


2.	All other terms and conditions of the Agreement shall remain in full force and effect as amended hereby.

By signing below, the parties hereby execute this valid and binding agreement effective as of the date listed above.



NORTHWESTERN UNIVERSITY		EXICURE, INC.
/s/ Alicia Löffler, Ph.D.		/s/ David A. Giljohann, Ph.D.
Alicia Löffler, Ph.D.		David A. Giljohann, Ph.D.
Associate Vice President for Research		Chief Executive Officer
and Executive Director, INVO

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.



Innovation and	Northwestern University	Phone ###-###-####	Northwestern \|INVO
New Ventures Office	1800 Sherman Ave, Suite 504	invo.northwestern.edu	Innovation and New Ventures
	Evanston, IL 60201

Exhibit A:



NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****



Innovation and	Northwestern University	Phone ###-###-####	Northwestern \|INVO
New Ventures Office	1800 Sherman Ave, Suite 504	invo.northwestern.edu	Innovation and New Ventures
	Evanston, IL 60201



NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****



Innovation and	Northwestern University	Phone ###-###-####	Northwestern \|INVO
New Ventures Office	1800 Sherman Ave, Suite 504	invo.northwestern.edu	Innovation and New Ventures
	Evanston, IL 60201



NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****



Innovation and	Northwestern University	Phone ###-###-####	Northwestern \|INVO
New Ventures Office	1800 Sherman Ave, Suite 504	invo.northwestern.edu	Innovation and New Ventures
	Evanston, IL 60201



NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****