Apellis Pharmaceuticals, Inc. Contracts & Agreements

Underwriting Agreement, dated February 22, 2023, by and among the Company and J.P. Morgan Securities LLC, Goldman Sachs & Co. LLC and Evercore Group L.L.C (Filed With SEC on February 24, 2023)

Form of Pre-Funded Warrant (Filed With SEC on February 24, 2023)

Form of Exchange Agreement (Filed With SEC on August 2, 2022)

Form of Exchange Agreement (Filed With SEC on July 27, 2022)

Underwriting Agreement, dated March 23, 2022, by and among the Company and J.P. Morgan Securities LLC, Goldman Sachs & Co. LLC and Evercore Group L.L.C (Filed With SEC on March 25, 2022)

Description of Securities Registered Under Section 12 of the Exchange Act (Filed With SEC on February 28, 2022)

Summary of Non-Employee Director Compensation Program (Filed With SEC on February 28, 2022)

Offer Letter, dated as of April 20, 2020, by and between the Registrant and Nur Nicholson (Filed With SEC on February 28, 2022)

Offer Letter, dated as of November 16, 2018, by and between the Registrant and Adam Townsend (Filed With SEC on February 28, 2022)

Open Market Sale AgreementSM, dated as of January 20, 2022, by and between Apellis Pharmaceuticals, Inc. and Jefferies LLC (Filed With SEC on January 20, 2022)

Underwriting Agreement, dated November 15, 2021, by and among the Company and J.P. Morgan Securities LLC, Goldman Sachs & Co. LLC and Evercore Group L.L.C (Filed With SEC on November 17, 2021)

Form of Exchange Agreement (Filed With SEC on July 8, 2021)

Amended and Restated Commercial Supply Agreement, dated March 10, 2021, by and between the Registrant, Apellis Switzerland GmbH and NOF Corporation (Filed With SEC on April 28, 2021)

Description of Securities Registered Under Section 12 of the Exchange Act (Filed With SEC on February 25, 2021)

Fourth Amendment to Lease, dated November 13, 2020, by and between Registrant and NWALP PHOP Property Owner LLC (Filed With SEC on February 25, 2021)

Form of Exchange Agreement (Filed With SEC on January 7, 2021)

Amendment No. 1 to 2017 Employee Stock Purchase Plan (Filed With SEC on November 2, 2020)

Form of Capped Call Transaction Confirmation (Filed With SEC on May 7, 2020)

Description of Securities Registered Under Section 12 of the Exchange Act (Filed With SEC on February 27, 2020)

Underwriting Agreement, dated January 8, 2020, by and among the Company and Citigroup Global Markets Inc., J.P. Morgan Securities LLC and Evercore Group L.L.C (Filed With SEC on January 9, 2020)

Third Amendment to Lease, dated September 25, 2019, by and between Registrant and NWALP PHOP Property Owner LLC (Filed With SEC on November 5, 2019)

Apellis Pharmaceuticals, Inc. Executive Separation Benefits and Retention Plan (Filed With SEC on October 7, 2019)

Form of Capped Call Transaction Confirmation (Filed With SEC on September 16, 2019)

Indenture (including form of Note), dated as of September 16, 2019, by and between Apellis Pharmaceuticals, Inc and U.S. Bank National Association, as trustee (Filed With SEC on September 16, 2019)

Amendment, dated as of June 7, 2019, to the Development Funding Agreement, dated as of February 28, 2019 by and between the Registrant and SFJ Pharmaceuticals XI, L.P (Filed With SEC on July 31, 2019)

Second Amendment to Lease, dated June 5, 2019, by and between Registrant and NWALP PHOP Property Owner LLC (Filed With SEC on July 31, 2019)

Offer Letter, dated as of April 13, 2018, by and between the Registrant and Lukas Scheibler (Filed With SEC on May 7, 2019)

Development Funding Agreement, dated as of February 28, 2019 by and between the Registrant and SFJ Pharmaceuticals XI, L.P (Filed With SEC on May 7, 2019)

Standard Office Lease, dated as of March 29, 2019, by and between the Registrant and Geary-Market Investment Company, Ltd (Filed With SEC on May 7, 2019)

Underwriting Agreement, dated March 6, 2019, by and among the Company and Citigroup Global Markets Inc., J.P. Morgan Securities LLC and Cowen and Company, LLC (Filed With SEC on March 7, 2019)

Fourth Addendum to Office Lease Agreement, dated as of July 2, 2018, by and between Registrant and Westwind Way Properties, LLC (Filed With SEC on July 31, 2018)

First Amendment to Lease, dated July 25, 2018, by and between Registrant and NWALP PHOP Property Owner LLC (Filed With SEC on July 31, 2018)

Form of Underwriting Agreement (Filed With SEC on April 16, 2018)

2017 Stock Incentive Plan (Filed With SEC on October 30, 2017)

Summary of Non-Employee Director Compensation Program (Filed With SEC on October 30, 2017)

2017 Employee Stock Purchase Plan (Filed With SEC on October 30, 2017)

Specimen stock certificate evidencing the shares of common stock (Filed With SEC on October 27, 2017)

Form of Incentive Stock Option Agreement under 2017 Stock Incentive Plan (Filed With SEC on October 27, 2017)

Form of Nonstatutory Stock Option Agreement under 2017 Stock Incentive Plan (Filed With SEC on October 27, 2017)

Form of Director and Officer Indemnification Agreement (Filed With SEC on October 27, 2017)

Form of Underwriting Agreement (Filed With SEC on October 20, 2017)

Offer Letter, dated as of October 9, 2017, by and between the Registrant and Timothy Sullivan (Filed With SEC on October 20, 2017)

Warrant to purchase shares of common stock issued to Golda Darty Partners S.A (Filed With SEC on October 20, 2017)

Warrant to purchase shares of common stock issued to Silicon Valley Bank (Filed With SEC on October 20, 2017)

Loan and Security Agreement, dated as of October 20, 2017, between the Registrant and Silicon Valley Bank (Filed With SEC on October 20, 2017)

Asset Purchase Agreement, dated as of September 24, 2014, by and between the Registrant and Potentia Pharmaceuticals, Inc (Filed With SEC on October 13, 2017)

Investors Rights Agreement, dated as of August 7, 2017, among the Registrant and the other parties thereto (Filed With SEC on October 13, 2017)

Voting Agreement, dated as of September 8, 2015, between the Registrant and Potentia Pharmaceuticals, Inc (Filed With SEC on October 13, 2017)

2010 Equity Incentive Plan, as amended (Filed With SEC on October 13, 2017)

Form of Incentive Stock Option Grant Notice and Agreement under 2010 Equity Incentive Plan (Filed With SEC on October 13, 2017)

Form of Nonstatutory Stock Option Grant Notice and Agreement under 2010 Equity Incentive Plan (Filed With SEC on October 13, 2017)

Patent License Agreement, dated as of March 28, 2008, by and between Apellis AG and The Trustees of the University of Pennsylvania, as assigned to the Registrant (Filed With SEC on October 13, 2017)

Amended and Restated Patent License Agreement, dated as of March 28, 2008, by and between Potentia Pharmaceuticals, Inc. and The Trustees of the University of Pennsylvania, as... (Filed With SEC on October 13, 2017)

Office Lease Agreement, dated as of October 21, 2010, by and between the Registrant and DHB Properties, LLC, as amended (Filed With SEC on October 13, 2017)

Consulting Agreement, dated as of September 10, 2015, by and between the Registrant and Danforth Advisors, LLC, as amended (Filed With SEC on October 13, 2017)

Lease, dated as of April 27, 2017, by and between the Registrant and NWALP PHOP Property Owner, LLC (Filed With SEC on October 13, 2017)

Offer Letter, dated as of March 7, 2017, by and between the Registrant and Steven Axon (Filed With SEC on October 13, 2017)

SUMMARY OF NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM (Filed With SEC on November 2, 2015)

ASSET PURCHASE AGREEMENT dated September 24, 2014 between APELLISPHARMACEUTICALS, INC. and POTENTIA PHARMACEUTICALS, INC. TABLE OF CONTENTS (Filed With SEC on October 13, 2015)

INVESTORS RIGHTS AGREEMENT TABLE OF CONTENTS (Filed With SEC on October 13, 2015)

VOTINGAGREEMENT (Filed With SEC on October 13, 2015)

APELLIS PHARMACEUTICALS, INC. 2010 EQUITY INCENTIVE PLAN As adopted May 12, 2010. ARTICLE 1 PURPOSE (Filed With SEC on October 13, 2015)

APELLIS PHARMACEUTICALS, INC. 2010 EQUITY INCENTIVE PLAN STOCK OPTION GRANT NOTICE (Filed With SEC on October 13, 2015)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. CONFIDENTIAL UNIVERSITYof PENNSYLVANIA Patent... (Filed With SEC on October 13, 2015)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. CONFIDENTIAL UNIVERSITY OF PENNSYLVANIA Amended... (Filed With SEC on October 13, 2015)

BLUEGRASS EYE BUILDING OFFICE LEASE AGREEMENT BY AND BETWEEN DHBPROPERTIES. LLC, A KENTUCKY PROFESSIONAL SERVICE CORPORATION (LANDLORD) AND APELLISPHARMACUTICALS, INC. A DELAWARE... (Filed With SEC on October 13, 2015)

CONSULTING AGREEMENT (Filed With SEC on October 13, 2015)