Amendment No. 2 to Product Agreement between Amylyx Pharmaceuticals, Inc. and Patheon Inc.
Amylyx Pharmaceuticals, Inc. and Patheon Inc. have agreed to amend their existing Product Agreement, originally effective November 12, 2019, regarding the manufacturing of AMX0035. This amendment, effective March 20, 2023, replaces Schedule A of the Product Agreement, updating terms related to pricing, process train, and batch size. All other terms of the original agreement remain unchanged unless specifically modified by this amendment. The amendment is legally binding and takes precedence over any conflicting terms in the previous agreements.
Exhibit 10.3
Certain identified information has been excluded from this exhibit because it is both not material and
is the type that the registrant treats as private or confidential. Information that was omitted has been
noted in this document with a placeholder identified by the mark “[***]”.
AMENDMEMENT NO. 2
TO THE PRODUCT AGREEMENT
BETWEEN PATHEONINC. AND AMYLYXPHARMACEUTICALS, INC.
(“Amendment No. 2”)
This Amendment No. 2, is effective as of March 20th, 2023 (“Effective Date”) by and between Amylyx Pharmaceuticals, Inc., having a principal place of business of business at 43 Thorndike Street, Cambridge, MA 02141 (“Client”) and Patheon Inc., having a principal place of businessat 111 Consumers Drive, Whitby, Ontario, L1N 5Z5 (“Patheon”).
WHEREAS Client and Patheon entered into a Master Manufacturing Services Agreement effective November 12, 2019 (the “Agreement”) that included as Appendix 1, that Product Agreement AMX0035 effective November 12, 2019 and as amended by Amendment No. 1 on January 18, 2021; (the “ProductAgreement”); and
WHEREAS Client and Patheon mutually desire to amend Schedule A to the Product Agreement with respect to pricing, process train and batch size (“Schedule A”).
NOW THEREFORE in consideration of the rights conferred and the obligations assumed herein, and for other good and valuable consideration (the receipt and sufficiency of which are acknowledged by each party), and intending to be legally bound the Parties agree as follows:
IN WITNESSWHEREOF, the parties heretohave caused their duly authorized representatives to sign this Amendment No. 2 upon the date first set forth above.
AMYLYX PHARMACEUTICALS, INC. PATHEON INC.
By: /s/ Joshua Cohen By: /s/ Matt Wilson
Name: Name: Matt Wilson
Title: Title: Director, Business Mgmt
Reason: Approver of the Non-GxP
EXHIBIT A
Schedule A CommercialSupply Pricing
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