Amylyx Pharmaceuticals, Inc. | Business Contracts

First Amendment, effective as of January 1, 2023, to the Supply Agreement, dated as of October 29, 2019, by and between the Registrant and CU Chemie Uetikon GmbH (Filed With SEC on May 11, 2023)

Second Amendment, dated as of March 20, 2023, to Product Agreement, dated as of November 12, 2019, as amended by Amendment No. 1, dated as of January 18, 2021, pursuant to the... (Filed With SEC on May 11, 2023)

First Amendment, dated as of January 18, 2021, to Product Agreement, dated as of November 12, 2019, pursuant to the Master Manufacturing Services Agreement, dated as of November... (Filed With SEC on May 11, 2023)

Non-Employee Director Compensation Policy (Filed With SEC on March 21, 2023)

Amendment to Employment Agreement, effective as of December 1, 2022, by and between the Company and Patrick Yeramian (Filed With SEC on December 6, 2022)

Form of Underwriting Agreement (Filed With SEC on October 4, 2022)

Description of Securities (Filed With SEC on March 31, 2022)

Employment Agreement, dated as of January 25, 2021, between the Registrant and James Frates (as currently in effect) (Filed With SEC on January 3, 2022)

Form of Employment Agreement, between the Registrant and Patrick D. Yeramian, M.D. (to be entered into in connection with this offering) (Filed With SEC on January 3, 2022)

Form of Employment Agreement, between the Registrant and Margaret Olinger (to be entered into in connection with this offering) (Filed With SEC on January 3, 2022)

Form of Employment Agreement, between the Registrant and James Frates (to be entered into in connection with this offering) (Filed With SEC on January 3, 2022)

Form of Employment Agreement, between the Registrant and Justin Klee (to be entered into in connection with this offering) (Filed With SEC on January 3, 2022)

Form of Employment Agreement, between the Registrant and Josh Cohen (to be entered into in connection with this offering) (Filed With SEC on January 3, 2022)

Employment Agreement, dated as of March 18, 2019, between the Registrant and Patrick D. Yeramian, M.D., as amended (as currently in effect) (Filed With SEC on January 3, 2022)

Employment Agreement, dated as of May 13, 2019, between the Registrant and Margaret Olinger, as amended (as currently in effect) (Filed With SEC on January 3, 2022)

Employment Agreement, dated as of August 1, 2015, between the Registrant and Justin Klee (as currently in effect) (Filed With SEC on January 3, 2022)

Employment Agreement, dated as of July 1, 2015, between the Registrant and Josh Cohen (as currently in effect) (Filed With SEC on January 3, 2022)

Non-Employee Director Compensation Plan (Filed With SEC on January 3, 2022)

Executive Cash Incentive Bonus Plan (Filed With SEC on January 3, 2022)

2022 Employee Stock Purchase Plan (Filed With SEC on January 3, 2022)

2022 Stock Option and Incentive Plan and form of award agreements thereunder (Filed With SEC on January 3, 2022)

2015 Stock Option and Incentive Plan and forms of award agreements thereunder (Filed With SEC on January 3, 2022)

Specimen stock certificate evidencing the shares of common stock (Filed With SEC on January 3, 2022)

Form of Underwriting Agreement (Filed With SEC on January 3, 2022)

Second Amended and Restated Investors Rights Agreement, dated as of July 1, 2021, among the Registrant and the other parties thereto (Filed With SEC on December 16, 2021)

Research, Development and Supply Agreement, dated as of December 9, 2019, and Deed of Amendment, dated as of July 26, 2021, by and between the Registrant and ICE S.p.A. (formerly... (Filed With SEC on December 16, 2021)

Master Manufacturing Services Agreement, dated as of November 12, 2019, by and between the Registrant and Patheon Inc (Filed With SEC on December 16, 2021)

Form of Officer Indemnification Agreement (Filed With SEC on December 16, 2021)

Form of Director Indemnification Agreement (Filed With SEC on December 16, 2021)

Lease Agreement, dated as of October 23, 2018, as amended, by and between the Registrant and Bullfinch Square Limited Partnership (Filed With SEC on December 16, 2021)

Amylyx Pharmaceuticals, Inc. (30)