Zynerba Pharmaceuticals, Inc. Contracts & Agreements

Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and James E. Fickenscher (Filed With SEC on August 14, 2023)

Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Form of Incentive Stock Option Agreement under Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Form of Non-Qualified Stock Option Agreement for Company Employees under Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Form of Non-Qualified Stock Option Agreement for Non-Employee Directors under Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Form of Restricted Stock Award Agreement under Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Form of Restricted Stock Award Agreement for Non-Employee Directors under Zynerba Pharmaceuticals, Inc. 2023 Stock Option and Incentive Plan (Filed With SEC on August 14, 2023)

Agreement and Plan of Merger, dated as of August 14, 2023, by and among Harmony Biosciences Holdings, Inc., Xylophone Acquisition Corp. and Zynerba Pharmaceuticals, Inc (Filed With SEC on August 14, 2023)

Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and Armando Anido (Filed With SEC on August 14, 2023)

Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and Terri B. Sebree (Filed With SEC on August 14, 2023)

Purchase Agreement, dated as of July 21, 2022, by and between Zynerba Pharmaceuticals, Inc. and Lincoln Park Capital Fund, LLC (Filed With SEC on July 21, 2022)

Registration Rights Agreement, dated as of July 21, 2022, by and between Zynerba Pharmaceuticals, Inc. and Lincoln Park Capital Fund, LLC (Filed With SEC on July 21, 2022)

Employment Agreement dated February 14, 2022, by and between the registrant and Albert P. Parker (Filed With SEC on March 1, 2022)

Zynerba Pharmaceuticals, Inc. Non-Employee Director Compensation Policy (Filed With SEC on March 1, 2022)

Form of Restricted Stock Grant Agreement under Amended and Restated 2014 Omnibus Incentive Compensation Plan (Filed With SEC on August 9, 2021)

Controlled Equity OfferingSM Sales Agreement, dated May 11, 2021, by and among the registrant, Cantor Fitzgerald & Co., Canaccord Genuity LLC, H.C. Wainwright & Co., LLC, and... (Filed With SEC on May 12, 2021)

Lease amendment No. 3 dated November 19, 2019, by and between Provco Devon, L.L.C. and the registrant (Filed With SEC on March 10, 2021)

Lease amendment No. 4 dated March 1, 2021, by and between Provco Devon, L.L.C. and the registrant (Filed With SEC on March 10, 2021)

Description of the Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 10, 2021)

Description of the Registrants Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 (Filed With SEC on March 10, 2020)

Amendment to the Employment Agreement, dated August 30, 2019, by and between the registrant and Brian Rosenberger (Filed With SEC on November 6, 2019)

Amendment to the Employment Agreement, dated August 30, 2019, by and between the registrant and Suzanne M. Hanlon (Filed With SEC on November 6, 2019)

Amendment to Employment Agreement, dated August 30, 2019, by and between Zynerba Pharmaceuticals, Inc. and Armando Anido (Filed With SEC on August 30, 2019)

Controlled Equity OfferingSM Sales Agreement, dated August 30, 2019, by and among Zynerba Pharmaceuticals, Inc., Cantor Fitzgerald & Co., Canaccord Genuity LLC, H.C. Wainwright &... (Filed With SEC on August 30, 2019)

Amendment to Employment Agreement, dated August 30, 2019, by and between Zynerba Pharmaceuticals, Inc. and James E. Fickenscher (Filed With SEC on August 30, 2019)

Amendment to Employment Agreement, dated August 30, 2019, by and between Zynerba Pharmaceuticals, Inc. and Terri B. Sebree (Filed With SEC on August 30, 2019)

Underwriting Agreement, dated July 20, 2018, by and between Zynerba Pharmaceuticals, Inc. and Cantor Fitzgerald & Co., as representative of the underwriters named therein (Filed With SEC on July 20, 2018)

Lease amendment dated February 9, 2018, by and between Provco Devon, L.L.C. and the registrant (Filed With SEC on March 12, 2018)

EMPLOYMENT AGREEMENT (Filed With SEC on May 9, 2017)

ZYNERBA PHARMACEUTICALS, INC. NONQUALIFIED STOCK OPTION GRANT (Filed With SEC on March 27, 2017)

Board of Directors Compensation Policy (Filed With SEC on March 27, 2017)

LEASE AMENDMENT (Filed With SEC on March 27, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on March 27, 2017)

2,800,000 Common Shares Zynerba Pharmaceuticals, Inc. UNDERWRITING AGREEMENT (Filed With SEC on January 19, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on November 14, 2016)

SEPARATION AGREEMENT (Filed With SEC on November 14, 2016)

[] Common Shares Zynerba Pharmaceuticals, Inc. UNDERWRITING AGREEMENT (Filed With SEC on July 23, 2015)

AMENDMENT TO ZYNERBA PHARMACEUTICALS, INC. AMENDED AND RESTATED 2014 OMNIBUS INCENTIVE COMPENSATION PLAN (Filed With SEC on July 23, 2015)

ZYNERBA PHARMACEUTICALS, INC. INDEMNIFICATION AGREEMENT (Filed With SEC on July 23, 2015)

Kentucky Science and Technology Corporation (KSTC) Grant Agreement No. KSTC-184-512-12-140 Kentucky Cabinet for Economic Development Office of Commercialization and Innovation... (Filed With SEC on June 30, 2015)

ZYNERBA PHARMACEUTICALS, INC. 2014OMNIBUS INCENTIVE COMPENSATION PLAN RESTRICTED STOCK GRANT (Filed With SEC on June 30, 2015)

Kentucky Science and Technology Corporation (KSTC) Grant Agreement No. KSTC-184-512-11-114 Kentucky Cabinet for Economic Development Office of Commercialization and Innovation... (Filed With SEC on June 30, 2015)

Kentucky Science and Technology Corporation (KSTC) Grant Agreement No. KSTC-184-512-07-029 Kentucky Cabinet for Economic Development Department of Commercialization and Innovation... (Filed With SEC on June 30, 2015)

Notice of Award (Filed With SEC on June 30, 2015)

Lease Agreement (Filed With SEC on June 30, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on June 30, 2015)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on June 30, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on June 30, 2015)

Lock-Up Agreement (Filed With SEC on June 30, 2015)

ZYNERBA PHARMACEUTICALS, INC. THIRD AMENDED AND RESTATED STOCKHOLDERS AGREEMENT (Filed With SEC on June 30, 2015)

Notice of Award SMALL BUSINESS INNOVATION RESEARCH PROG Department of Health and Human Services National Institutes of Health NATIONAL INSTITUTE ON DRUG ABUSE Issue Date:... (Filed With SEC on June 30, 2015)

PATENT ASSIGNMENT (Filed With SEC on June 30, 2015)

Broadband Capital Management LLC | 712 Fifth Avenue, New York, New York 10019 | tel ###-###-#### | fax ###-###-#### www.broadbandcapital.com Member FINRA, SIPC (Filed With SEC on June 30, 2015)

AGREEMENT AND PLAN OF MERGER BY AND AMONG BCM XI HOLDINGS LLC, BCM PARTNERS IV, CORP., ALLTRANZ, INC., AUDRA STINCHCOMB and Steven Gailar, as the representative of the... (Filed With SEC on June 30, 2015)

[Signature page follows] 2 (Filed With SEC on June 30, 2015)

[Signature page follows] Broadband Capital Management LLC | 712 Fifth Avenue, New York, New York 10019 | tel ###-###-#### | fax ###-###-#### www.broadbandcapital.com Member FINRA,... (Filed With SEC on June 30, 2015)

STOCK TRANSFER AGREEMENT (Filed With SEC on June 30, 2015)

Notice of Award (Filed With SEC on June 30, 2015)

SEVERANCE AGREEMENT AND RELEASE OF CLAIMS (Filed With SEC on June 30, 2015)

Notice of Award (Filed With SEC on June 30, 2015)

Notice of Award RESEARCH PROJECT Issue Date: 06/09/2011 Department of Health and Human Services National Institutes of Health NATIONAL INSTITUTE ON DRUG ABUSE (Filed With SEC on June 30, 2015)

PATENT ASSIGNEMENT CONSIDERATION AGREEMENT (Filed With SEC on June 30, 2015)

TERMINATION AND RELEASE AGREEMENT (Filed With SEC on June 30, 2015)

ZYNERBA PHARMACEUTICALS, INC. AMENDED AND RESTATED 2014 OMNIBUS INCENTIVE COMPENSATION PLAN (Filed With SEC on June 30, 2015)

ZYNERBA PHARMACUETICALS, INC. 2014 OMNIBUS INCENTIVE COMPENSATION PLAN INCENTIVE STOCK OPTION GRANT (Filed With SEC on June 30, 2015)

ZYNERBA PHARMACEUTICALS, INC. 2014 OMNIBUS INCENTIVE COMPENSATION PLAN NONQUALIFIED STOCK OPTION GRANT (Filed With SEC on June 30, 2015)