Amendment No. 1 to Manufacturing Services Agreement between Patheon Italia S.p.A. and ZymoGenetics, Inc. (rhThrombin)
This amendment, effective December 3, 2007, updates the Manufacturing Services Agreement between Patheon Italia S.p.A. and ZymoGenetics, Inc. regarding the production of rhThrombin. The main change is the replacement of Schedule H, which defines the territories covered by the agreement, now including a detailed list of countries across the United States, Europe, Canada/Latin America, Asia/Pacific, and Japan. All other terms of the original agreement remain unchanged and in effect.
Confidential
Exhibit 10.49
Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
This Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin, dated as of December 3, 2007 (“Effective Date”), is entered into by and between Patheon Italia S.p.A. (“Patheon”) and ZymoGenetics, Inc., a Washington corporation (“ZGEN”).
The parties hereby agree that the Manufacturing Services Agreement relating to rhThrombin, dated January 1, 2006 (the “Agreement”) shall be amended as follows:
| 1. | Territory |
Schedule H shall be replaced by the updated Schedule H attached hereto.
| 2. | Ratification of Agreement |
All other terms and obligations of the Agreement shall remain in full force and effect.
IN WITNESS WHEREOF, ZGEN and Patheon have executed this Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin as of the Effective Date.
| Patheon Italia S.p.A. | ZymoGenetics, Inc. | |||
| /s/ Aldo Braca | /s/ Vaughn B. Himes | |||
| Aldo Braca | Vaughn B. Himes, Ph.D. | |||
| Managing Director Patheon Italia S.p.A. – President Patheon Europe | Senior Vice President, Technical Operations | |||
| Date: December 3, 2007 | Date: December 5, 2007 | |||
Confidential
SCHEDULE H
TERRITORY
United States of America
Countries within Europe
| • Albania | • Andorra | • Armenia | ||
| • Austria | • Azerbaijan | • Belarus | ||
| • Belgium | • Bosnia and Herzegovina | • Bulgaria | ||
| • Croatia | • Cyprus | • Czech Republic | ||
| • Denmark | • Estonia | • Finland | ||
| • France | • Georgia | • Germany | ||
| • Greece | • Hungary | • Iceland | ||
| • Ireland | • Italy | • Kazakhstan | ||
| • Kyrgyzstan | • Latvia | • Liechtenstein | ||
| • Lithuania | • Luxembourg | • Macedonia | ||
| • Malta | • Moldova | • Monaco | ||
| • Montenegro | • Netherlands | • Norway | ||
| • Poland | • Portugal | • Romania | ||
| • Russia | • San Marino | • Serbia | ||
| • Slovakia | • Slovenia | • Spain | ||
| • Sweden | • Switzerland | • Tajikistan | ||
| • Turkey | • Turkmenistan | • Ukraine | ||
| • United Kingdom | • Uzbekistan | • Vatican City | ||
Countries within Canada/Latin America Region
| • Canada | • Mexico | • Argentina | ||
| • Bolivia | • Brazil | • Chile | ||
| • Colombia | • Dominican Republic | • Ecuador | ||
| • El Salvador | • Guatemala | • Nicaragua | ||
| • Paraguay | • Peru | • Uruguay | ||
| • Venezuela | • Costa Rica | • Honduras | ||
| • Panama | • Belize | • Cuba | ||
| • French Guiana | • Guadeloupe | • Guyana | ||
| • Haiti | • Suriname | |||
Countries within Asia/Pacific Region
| • Australia | • Cambodia | • China | ||
| • Hong Kong | • Indonesia | • India | ||
| • Malaysia | • New Zealand | • Pakistan | ||
| • Philippines | • Singapore | • South Korea | ||
| • Vietnam | • Taiwan | • Thailand | ||
| • Bahrain | • Bangladesh | • Bhutan | ||
| • Brunei | • Israel | • Jordan | ||
| • Kuwait | • Oman | • Qatar | ||
| • Saudi Arabia | • United Arab Emirates | |||
Countries within Japan Region
| • Japan |
