Second Amendment to API Supply Agreement, dated as of May 2, 2022, by and between

WHEREAS Xeris and Bachem entered into that certain API Supply Agreement for Glucagon, dated and effective January 1, 2018, and that certain First Amendment to API Supply Agreement dated February 26, 2021 (collectively “the Agreement”); and

WHEREAS the Parties have agreed to amend the Agreement to update Glucagon tiered pricing for Calendar Year [***], and to set forth a mechanism to review and confirm recently negotiated [***] pricing for the years [***];

NOW THEREFORE in consideration of the mutual promises contained herein, effective as of the Second Amendment Effective Date, the Parties affirm and agree as follows:

1.Exhibit 1, API Pricing, of the Agreement is hereby deleted and replaced with Exhibit 1 attached hereto, which contains [***] tiered pricing for Glucagon beginning Calendar Year [***], and [***] tiered pricing for Glucagon for the years [***];

2.Section 3.4 is hereby added to the Agreement as follows:

3.4 Annual Price Adjustment. The Parties acknowledge that annual price adjustments may be necessary to account for changes in the Specifications or a change in BACHEM's cost of (i) raw materials; or (ii) labor costs; or (iii) costs for energy and other utilities; or (iv) any other costs to manufacture the Product that results in a material increase in the cost of manufacturing of the API. BACHEM and XERIS agree to meet once annually, acting reasonably and in good faith, to review and confirm in writing by September 30th of each prior year the [***] tiered pricing set forth in Exhibit 1.

This Second Amendment shall be governed by, and construed in accordance with, the laws of the State of New York, as if entered into by New York residents and executed and wholly performed within the State of New York. This Second Amendment may be executed in counterparts, each of which shall be deemed an original, but which together shall constitute one and the same instrument. All other terms, conditions and obligations of the Agreement shall remain in force. To the extent any provision of the Agreement conflicts with any provision of this Second Amendment, this Second Amendment shall control.