SUPPLY AND DISTRIBUTION AGREEMENT

Exhibit 10.21

SUPPLY AND DISTRIBUTION AGREEMENT

This Agreement is made between

VIRANATIVE AB having its principal address at Tvistevägen 48, S-907 36 UMEÅ, Sweden.

hereinafter referred to as “the Company” and

LABORATORIOS PISA, S.A. DE. C.V., a Mexican Company having its registered Head Office in Av. España No. 1840, 44190 Guadalajara, Jalisco, Mexico,

hereinafter referred to as “the Distributor”.

The purpose of this Agreement is to grant the Distributor the exclusive right to market, sell and distribute the Product within the Territory as defined in Exhibit A and in accordance with the terms and conditions expressed herein.

In this Agreement, each time the following terms are used with initial capitals, their meanings shall be as specified hereunder.

1 of 15

The Company hereby appoints the Distributor as its exclusive Distributor for the Product in the Territory (as defined in Exhibit A) and Distributor hereby accepts such appointment in accordance with the terms and conditions herein expressed.

Performance Schedule

2 of 15

3 of 15

The Company shall refrain from selling the Product in the Territory and shall not grant nor appoint any other person or entity as Distributor of the Product in the Territory.

The Distributor shall not manufacture, sell or distribute any interferon or other products which compete with the Product. The Distributor may, however, continue its business activities with respect to such products as it sells or distributes on the date of signing this agreement as reflected in Exhibit E. The Distributor may nominate a Sub-Distributor upon submission of a request for approval and a copy of the draft Sub-Distributor Agreement which shall be submitted to the Company for its approval. No Sub-Distributor agreement shall be valid without the written approval of the Company.

From the date of this agreement, Distributor shall not distribute, directly or indirectly, any products containing the same active ingredients as the Product.

The Distributor hereby warrants that it shall not seek customers for the Product outside the Territory, sell the Product outside the Territory, or establish any branch or maintain any distribution depot outside the Territory. The Sub-Distributor Agreement shall require the Sub-Distributor to so warrant and the Distributor shall be accountable to the Company for enforcing this provision.

The Distributor shall not have the right to produce the active ingredient of the Product.

The Distributor agrees to furnish the Company within 30 (thirty) days after each calendar quarter, or at such intervals as agreed upon by the Company and the Distributor, with a true and accurate report on all sales of the Product in the Territory, as specified herein. The Distributor agrees to also furnish the Company with copies of all agreements, brochures, pamphlets and documents which may relate to the Product including those developed, produced or used by the Distributor in connection with the sale of the Product. The Distributor agrees to design all promotional materials according to company’s branding guidelines. The Distributor agrees not to use any such material without the Company’s prior written approval. Upon submission, the Company agrees to respond promptly without any unnecessary delay and consent shall not be unreasonably withheld.

At any time upon reasonable request of the Company, Distributor agrees provide the Company with information, including but limited to, selling prices, market trends, competitive environment and competitor’s prices, technical or commercial information useful for the adaptation of the Product to market requirements.

4 of 15

Distributor agrees to send to the Company a quarterly report on market developments in the Territory and Distributor’s sales progress relating to the Product.

At any time and upon reasonable request of the Company, Distributor shall permit the Company’s representative(s) to accompany Distributor’s representative(s) on visits made to customers in order to have the Company better acquainted with the specificity of the market for the Product in the Territory. The Company agrees to send a letter of notice of at least 30 calendar days prior to the visits. The Company agrees not to circumvent the Distributor during the term hereof and any renewal.

Following PL approval, the Distributor shall submit to the Company each calendar quarter during each calendar year a rolling forecast for the following 4 (four) quarters showing the planned purchase quantities of the Product. The Distributor shall place its firm orders for the Product for the following quarter with the rolling forecast. Before approval by the Company, the Distributor shall submit each month a rolling forecast for the following twelve months connected to firm orders for the Product for the following quarter.

The Company shall provide the Distributor with all presently available data, information and documents necessary for the carrying out of this Agreement, including technical documents and advertising material. The Company shall provide the Distributor with any significant Know How related to the Products, in addition to that already provided as of the date hereof, which may be or shall become available to the Company, whether originated by the Company or its Affiliated Companies, and which the Company is free to disclose.

The Distributor shall buy and maintain, at his own cost, an inventory of the Product equaling no less than the amount forecasted for the following quarter and see to it that the Product is kept in good condition and that all reasonable precautions are taken to prevent its deterioration at its own cost, expense and liability.

The Distributor shall buy and sell the Product in its own name and for its own account and act in all respects as an independent contractor. The Distributor shall organize the distribution of the Product in such a manner as to most effectively promote the sale of the Product and maintain a level of product support necessary for the proper selling, marketing and distribution of the Product.

5 of 15

This Agreement does not designate the Distributor to be the agent, partner or legal representative of the Company for any purpose whatsoever, and the business conducted by the Distributor pursuant to this Agreement with third parties shall be wholly at the Distributor’s own risk and account as an independent contractor.

The Distributor is not granted any right or authority to assume or create any obligation or responsibility, express or implied, on behalf of or in the name of the Company or to bind the Company in any manner whatsoever.

The Distributor shall inform the Company of all acts of unfair competition and of all infringement of patents, trade mark, trade names, or similar rights of the Company which have come to its attention to the extent that the rights of the Company have been violated. If requested by the Company, the Distributor shall assist the Company at the Company’s expense in any action or litigation involving such acts or infringements.

In order to enable the Company to comply with the requirements of the European Code of Good Manufacturing Practice (Volume IV of the Rules Governing Medical Products in the European Community), the Distributor shall keep Distribution Records for each Batch of the Product sold to the customers. This information shall be made available to the Company in case of Recall Operation, within two working days, by sending a fax, confirmed by a letter, to:

ViraNative AB

Tvistevagen 48

S-907 36 Umeå

Sweden

Tel no: 46-90-172250

Fax no: 46-90-193736

The Distributor shall send all orders for the Product to be purchased under this Agreement to the Company together with adequate delivery instructions. The Company shall deliver the Products to Distributor in a period no longer than three (3) months from receipt of the relevant Purchase Order. Orders presented by the Distributor shall bind the Company after written confirmation of acceptance thereof by the Company which shall be sent to Distributor upon 3 (three) business days following receipt of the Purchase Order. Silence in these regards following such three-day period, shall be deemed as acceptance of the Purchase Order and its terms.

6 of 15

The Distributor shall purchase the Product at prices and on conditions set forth by the Company from time to time in Exhibit B. Notwithstanding the above, any price increase will be mutually discussed in good faith by the Parties, and Exhibit B shall be deemed as amended accordingly.

The Distributor shall pay the Company for the Product supplied according to payment terms as set forth in Exhibit B.

The Distributor shall use its best efforts and diligence in promoting and initiating effectively the sales of the Product throughout the whole of its Territory.

The Distributor shall ensure the advertising and the promotion of the Product and, to a reasonable extent, the participation in conventions, trade shows and exhibitions held in the Territory. The costs of advertising and promotion are to be borne by the Distributor. All advertising and promotional copy shall be submitted to the Company for its written approval prior to release.

7 of 15

The Distributor shall not, even after the expiration of this Agreement, use or communicate to any third party any trade secrets which the Distributor has come to know in one way or another through its work for the Company. The obligation shall cease at the end of a period of (five) 5 years from the date of the termination or expiration of this Agreement; however, the obligation shall not cease for any reason prior to the end of the first (ten) 10 years after the signing of the Agreement.

The Distributor assumes the responsibility, liability and obligations that its employees and any Sub-Distributor and its employees shall preserve the secrecy of trade secrets with respect to third parties.

Trademarks, Tradenames and Copyrights used by the Distributor for the Product shall be the property of the Company, and the Distributor agrees to use only such Trademarks, Tradenames and Copyrights as indicated and approved in writing by the Company. It is agreed that the Company’s registered trademark of the Product, Multiferon^™ may be used in the Territory, provided a registration of these trademarks will be obtainable and maintained.

The Distributor shall not, without the Company’s prior written consent, use the Company’s corporate name, telegraphic address, graphic or other trademarks, whether during the maintenance of or after the termination of this Agreement.

The Distributor shall not register or attempt to register for any purpose any trade-mark, tradename, copyright, name, title or expression of the Company as used on the Product or any other trademark or any tradename which is similar thereto.

Electronic emails may be considered adequate consent if originated at the Company’s premises.

Should Distributor become aware of any breach on the part of third parties of Patents, Trademarks or Know How relative to the Products, it shall immediately inform the Company and shall provide the Company with the widest assistance in order to protect such rights.

Distributor undertakes to cooperate with the Company in preventing all breaches of Patents, Trademarks or Know How relative to the Products upon the terms of the subsequent paragraph and in any event to prevent said breaches using its best efforts.

In the case of possible breaches of Distributor, Trademarks or Know How on the part of third parties, Distributor undertakes to cooperate with the Company and with the Company’s attorneys in order to allow the correct carrying out of legal actions.

The Company shall inform the Distributor of all acts of unfair competition and of all infringements of Patents, Trademarks, Tradenames or similar rights of Distributor which have come to its attention to the extent that the rights of the Distributor have

8 of 15

been violated. If requested by Distributor, the Company shall assist Distributor at Distributor’s expense in any action or litigation involving such acts or infringements.

Distributor shall immediately report to the Company any actual or threatened infringement or imitation of said intellectual properties, which it may learn, by giving written information of all details available concerning said infringement.

Distributor shall not institute or bring legal actions or proceedings against such infringers without prior written authorization from the Company.

Costs and expenses for legal actions or proceedings shall be borne by the Company, which, however, will not be obliged to act.

The Parties shall have the right to assign this Agreement, upon written notice to the other Party but without the prior consent such Party, to:

Each party reserves the right to terminate this Agreement whenever the control of the other party passes over to another party other than the party controlling it at the time of signature of this present Agreement.

If due performance of this Agreement by either party is affected in whole or in part by reason of any event, omission, accident, general shortage of commodities, legal circumstances or other matter beyond the reasonable control of such party, it shall give prompt notice thereof to the other party and shall be under no liability for any loss, damage, injury or expense suffered by the other party for this reason. Both parties shall use all reasonable efforts to avoid or overcome the causes affecting performance and the party whose performance is affected by such force majeure shall fulfill all outstanding obligations as soon as possible.

9 of 15

The Distributor agrees that it will, on its own comply with all laws, statutes and ordinance in the Territory relating to the import and sale of the Product and agrees to

10 of 15

indemnify and hold the Company harmless in the event that any claim is made against it by reason of the Distributor’s failure to so comply. In particular, the Distributor agrees to comply with all safety laws and regulations in the Territory relating to the Product and the Company agrees to provide all necessary information and assistance to the Distributor to enable it to so comply.

The Distributor shall pay all excise or sales taxes that may be required to be paid by the Company or the Distributor by any statute, ordinance or regulation of any taxation authority. In the event that the Company is required to or does pay any of such taxes, the Distributor, upon being informed of such payment, shall at once repay the amount thereof to the Company. The Distributor, unless prohibited by any such statute, ordinance or regulation, shall have the right to require any dealer or Sub-Distributor handling such goods to pay any such excise or sales taxes on the goods so handled by him.

This Agreement shall have immediate force and effect and shall remain in effect until the completion of a ten (10) year Period, and shall continue thereafter for an additional three (3) year term and continue thereafter for two automatic three (3) year terms unless and until terminated by either party giving to the other six (6) months notice in writing prior to the end of the Initial Term or any Subsequent Term.

This Agreement may be terminated with three (3) months written notice forthwith by either party if the other party fails to fulfill any of its obligations under this Agreement and such default is not remedied within thirty (30) days of the date on which a written notice thereof has been dispatched to the defaulting party or if the Distributor fails to obtain or maintain the PL as set forth in Article 6, Medical Registration.

Notwithstanding the foregoing, in case Distributor does not achieve the volumes of sales stated on the Performance Schedule in section 5.1 herein, for causes satisfactorily evidenced and justified to the Company and not attributable to Distributor (i.e. material adverse effects on the market or economic situation in the Territory), such event shall not be deemed as a cause for termination of this

11 of 15

Agreement and, therefore, the Company may not terminate this agreement for this specific situation.

This Agreement may be terminated immediately in the event that either party is declared insolvent, is adjudged bankrupt or files a petition for bankruptcy or reorganization under any bankruptcy law, is expropriated or sequestrated or submits or has to submit to any other administrative or judicial measures of control.

Insolvency is defined to mean the inability to pay debts, as they become due and the excess of liabilities over assets.

The Company shall have a right to terminate this Agreement with immediate effect should the Company’s license to sell the Product be withdrawn.

If this Agreement is terminated by the Company without cause, the Company shall reimburse Distributor for all expenses incurred by Distributor in connection to clinical trials of the product.

On the termination of this agreement, the Distributor shall return, without delay, all registration and permission documents to the Company together with all formulas, manufacturing procedures and other confidential documentation which the Distributor has obtained from the Company. The Distributor agrees that it shall not make any further use of this documentation. The Company shall have the option to repurchase any paid unsold Product at prices paid by the Distributor to the Company.

Notice of termination shall be in writing and shall be deemed given: (i) upon personal delivery to the appropriate address, (ii) upon delivery to the appropriate address if sent by certified or registered mail, (iii) one business day after the date of deposit with an express mail overnight courier, or (iv) if by facsimile, upon the transmittal of same with printed confirmation of receipt.

In the event Distributor fails to achieve seventy percent (70%) of the sales figures set forth under “Performance Standards” in paragraph 5.1, then the exclusive distribution rights as set forth herein may be cancelled by the Company, and shall notify the Distributor with a written notice of no less than three (3) months prior to the cancellation date, unless, as stated in clause 11.2.1, the lack of achievement is due to

12 of 15

causes satisfactorily evidenced and justified to the Company and not attributable to Distributor.

Neither party hereto shall be liable to the other for any termination compensation whether based on goodwill, loss of income or otherwise.

This Agreement shall be governed by the laws of Sweden

The English text of this Agreement shall prevail.

Any dispute in connection with this agreement shall be definitely and incontestably solved by the arbitration and conciliation statute according to the rules of the International Chamber of Commerce in Paris by three arbitrators who will be designated according to this statute.

The arbitration seat will be in Paris, the arbitration language will be English and the Swedish law will be applicable to the merits of the disputes.

All modifications and amendments to this Agreement shall be in writing and signed by the Parties.

All notices in connection with this Agreement shall be in writing and be in the English language, as shall all other written communications and correspondence, and may be given by personal delivery, prepaid registered airmail letter, facsimile, or telegram addressed to the Party required or entitled to receive the same at its address or facsimile number set out below, or to such other address or facsimile number as such Party shall have designated by like notice to the other Party. Notice of termination of this Agreement if given by facsimile or telegram shall be confirmed by prepaid registered airmail letter dated and posted within 24 hours. The effective date of any notice if served by personal delivery, facsimile, or telegram shall be deemed the first business day in the city of destination following the dispatch and if given by prepaid registered airmail letter only, it shall be deemed served seven days after the date of posting.

13 of 15

All Exhibits attached hereto shall be made a part of this Agreement.

The omission by either Party to exercise any right hereunder shall not constitute a waiver thereof and shall not prevent the subsequent enforcement of that right and shall not be deemed to be a waiver of any subsequent right.

The provisions of this Agreement shall survive its termination for so long as may be necessary to give efficacy thereto.

This Agreement, which includes the Exhibits attached hereto, contains the entire understanding and supersedes all prior agreements of the parties with respect to the transactions contemplated hereby, especially, this Agreement substitutes the Agreement executed by and between Alfanative AB and Distributor dated as of July 14, 1998. There are no agreements, promises, warranties, covenants or understandings other than those expressly set forth herein.

Any provision of this Agreement that is invalid or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such invalidity or unenforceability without invalidating the remaining provisions hereof or affecting the validity or enforceability of such provision in any other jurisdiction.

14 of 15

IN WITNESS WHEREOF the parties hereto have hereunto set their hands the day and year indicated below.

15 of 15