Vertex Pharmaceuticals Inc Contracts & Agreements

First Amendment to Credit Agreement, dated June 20, 2024, by and between Vertex Pharmaceuticals Incorporated and Bank of America N.A (Filed With SEC on August 2, 2024)

Amendment No. 1 to Amended and Restated Joint Development and Commercialization Agreement, dated December 23, 3023, between Vertex Pharmaceuticals Incorporated, Vertex... (Filed With SEC on February 15, 2024)

Vertex Pharmaceuticals Employee Compensation Plan (Filed With SEC on February 15, 2024)

Description of Securities (Filed With SEC on February 10, 2023)

Amendment No. 2 to Employment Agreement, between Jeffrey M. Leiden and Vertex Pharmaceuticals Incorporated, dated as of February (Filed With SEC on February 10, 2023)

Vertex Pharmaceuticals Employee Compensation Plan (Filed With SEC on February 10, 2023)

Amendment No. 1 to Employment Agreement, between Jeffrey M. Leiden and Vertex (Filed With SEC on February 9, 2022)

Employment Agreement, dated August 1, 2020, by and between Vertex Pharmaceuticals Incorporated and Nia Tatsis (Filed With SEC on February 9, 2022)

Change of Control Agreement, dated August 1, 2020, by and between Vertex Pharmaceuticals Incorporated and Nia Tatsis (Filed With SEC on February 9, 2022)

Vertex Pharmaceuticals Non-Employee Board Compensation (Filed With SEC on February 9, 2022)

Research, Development and Commercialization Agreement, dated as of May 24, 2004, between Vertex Pharmaceuticals Incorporated and Cystic Fibrosis Foundation Therapeutics... (Filed With SEC on November 3, 2021)

Amendment No. 1 to Research, Development and Commercialization Agreement, dated as of January 6, 2006, between Vertex Pharmaceuticals Incorporated and Cystic Fibrosis Foundation... (Filed With SEC on November 3, 2021)

Amendment No. 5 to Research, Development and Commercialization Agreement, effective as of April 1, 2011, between Vertex Pharmaceuticals Incorporated and Cystic Fibrosis Foundation... (Filed With SEC on November 3, 2021)

Amendment No. 7 to Research, Development and Commercialization Agreement, dated October 13, 2016, between Vertex Pharmaceuticals Incorporated and Cystic Fibrosis Foundation... (Filed With SEC on November 3, 2021)

Amended and Restated Joint Development and Commercialization Agreement, dated April 16, 2021, between Vertex Pharmaceuticals Incorporated, Vertex Pharmaceuticals (Europe) Limited... (Filed With SEC on July 30, 2021)

Lease, dated May 5, 2011, between Fifty Northern Avenue LLC and Vertex Pharmaceuticals Incorporated (Filed With SEC on July 30, 2021)

Lease, dated May 5, 2011, between Eleven Fan Pier Boulevard LLC and Vertex Pharmaceuticals Incorporated (Filed With SEC on July 30, 2021)

Joint Development and Commercialization Agreement, dated December 12, 2017, between Vertex Pharmaceuticals Incorporated, Vertex Pharmaceuticals (Europe) Limited and CRISPR... (Filed With SEC on February 11, 2021)

Employment Agreement, dated as of April 1, 2020, between Vertex Pharmaceuticals Incorporated and Dr. Jeffrey M. Leiden (Filed With SEC on April 1, 2020)

Description of Securities (Filed With SEC on February 13, 2020)

Form of Restricted Stock Unit Agreement Under 2013 Stock and Option Plan (Filed With SEC on February 13, 2020)

Amended and Restated Change of Control Agreement, dated as of May 18, 2012, between Vertex Pharmaceuticals Incorporated and Paul M. Silva (Filed With SEC on February 13, 2020)

Agreement and Plan of Merger, dated as of August 30, 2019, by and among Vertex Pharmaceuticals Incorporated, Vertex Disc Inc., Semma Therapeutics, Inc., and Shareholder... (Filed With SEC on October 31, 2019)

Agreement and Plan of Merger, dated as of June 6, 2019, among Vertex Pharmaceuticals Incorporated, VXP Merger Sub, Inc., Exonics Therapeutics, Inc. and Shareholder Representative... (Filed With SEC on August 1, 2019)

Employment Agreement, dated as of July 24, 2019, between Vertex Pharmaceuticals Incorporated and Reshma Kewalramani (Filed With SEC on July 25, 2019)

Change of Control Agreement, dated as of July 24, 2019, between Vertex Pharmaceuticals Incorporated and Reshma Kewalramani (Filed With SEC on July 25, 2019)

Amendment No. 1, dated as of July 24, 2019, to the Amended and Restated Employment Agreement, dated November 30, 2016, by and between Vertex Pharmaceuticals Incorporated and... (Filed With SEC on July 25, 2019)

Employment Agreement, dated March 28, 2019, by and between Vertex Pharmaceuticals Incorporated and Charles F. Wagner, Jr (Filed With SEC on May 1, 2019)

Change of Control Agreement, dated as of March 28, 2019, by and between Vertex Pharmaceuticals Incorporated and Charles F. Wagner, Jr (Filed With SEC on May 1, 2019)

Vertex Pharmaceuticals Non-Employee Board Compensation (Filed With SEC on February 13, 2019)

2006 Stock and Option Plan, as amended (Filed With SEC on October 25, 2018)

Amended and Restated 2013 Stock and Option Plan (Filed With SEC on October 25, 2018)

Employment Agreement, dated as of September 6, 2017, between Vertex Pharmaceuticals Incorporated and Tom Graney (Filed With SEC on October 30, 2017)

Change of Control Agreement, dated as of September 6, 2017, between Vertex Pharmaceuticals Incorporated and Tom Graney (Filed With SEC on October 30, 2017)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Triple asterisks denote omissions. (Filed With SEC on April 28, 2017)

Asset Purchase Agreement Dated as of March 3, 2017 between Concert Pharmaceuticals, Inc., as Seller and Vertex Pharmaceuticals (Europe) Limited, as Buyer and, solely for purposes... (Filed With SEC on April 28, 2017)

FIRST AMENDMENT TO LEASE (Filed With SEC on April 28, 2017)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Triple asterisks denote omission. Amendment No. 7 Research, Development and... (Filed With SEC on February 23, 2017)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on December 2, 2016)

EXHIBIT 10.1 VERTEX PHARMACEUTICALS INCORPORATED EMPLOYEE STOCK PURCHASE PLAN (as amended and restated as of July 12, 2016) ARTICLE 1 PURPOSE AND DEFINITIONS (Filed With SEC on August 1, 2016)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Triple asterisks denote omissions. (Filed With SEC on February 16, 2016)

LEASE AGREEMENT (Filed With SEC on February 16, 2016)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Restricted Stock Unit Award (Filed With SEC on February 16, 2016)

VERTEX PHARMACEUTICALS NON-EMPLOYEE DIRECTOR DEFERRED COMPENSATION PLAN Effective January 1, 2016 (Filed With SEC on February 16, 2016)

EMPLOYMENT AGREEMENT (Filed With SEC on February 16, 2016)

Vertex Employee Compensation Plan (Filed With SEC on February 16, 2016)

Vertex Pharmaceuticals Non-Employee Board Compensation (Filed With SEC on February 16, 2016)

SECOND AMENDMENT TO CREDIT AGREEMENT (Filed With SEC on October 30, 2015)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Triple asterisks denote omissions. (Filed With SEC on August 4, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on May 4, 2015)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on February 13, 2015)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on February 13, 2015)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on February 13, 2015)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on February 13, 2015)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on February 13, 2015)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on February 13, 2015)

Vertex Employee Compensation Plan (Filed With SEC on February 13, 2015)

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 15, 2014)

CREDIT AGREEMENT Dated as of July 9, 2014 among VERTEX PHARMACEUTICALS INCORPORATED, as the Borrower, MACQUARIE US TRADING LLC, as Administrative Agent, and The Other Lenders... (Filed With SEC on July 31, 2014)

Confidential Treatment Requested. Confidential portions of this document have been redacted and have been separately filed with the Commission. 2013 Amendment to License,... (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on February 11, 2014)

Vertex Employee Compensation Plan (Filed With SEC on February 11, 2014)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Non-Qualified Stock Option Grant (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Award (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN Form of Restricted Stock Unit Award (Filed With SEC on August 2, 2013)

VERTEX PHARMACEUTICALS INCORPORATED 2013 STOCK AND OPTION PLAN (Filed With SEC on May 8, 2013)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on March 1, 2013)

SEPARATION AGREEMENT & GENERAL RELEASE (Filed With SEC on March 1, 2013)

Vertex Employee Compensation Plan (Filed With SEC on March 1, 2013)

EMPLOYMENT AGREEMENT (Filed With SEC on November 6, 2012)

EMPLOYMENT AGREEMENT (Filed With SEC on August 8, 2012)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK AND OPTION PLAN (Filed With SEC on August 8, 2012)

VERTEX PHARMACEUTICALS INCORPORATED EMPLOYEE STOCK PURCHASE PLAN (as amended and restated) ARTICLE 1 PURPOSE AND DEFINITIONS (Filed With SEC on August 8, 2012)

Confidential Treatment Requested Confidential portions of this document have been redacted and have been separately filed with the Commission (Filed With SEC on August 9, 2011)

Confidential Treatment Requested Confidential portions of this document have been redacted and have been separately filed with the Commission RESEARCH, DEVELOPMENT AND... (Filed With SEC on August 9, 2011)

Confidential Treatment Requested Confidential portions of this document have been redacted and have been separately filed with the Commission AMENDMENT NO. 5 to RESEARCH,... (Filed With SEC on August 9, 2011)

Confidential Treatment Requested Confidential portions of this document have been redacted and have been separately filed with the Commission (Filed With SEC on August 9, 2011)

CREDIT AGREEMENT Dated as of January 7, 2011 among VERTEX PHARMACEUTICALS INCORPORATED, as the Borrower, BANK OF AMERICA, N.A., as Administrative Agent, and The Other Lenders... (Filed With SEC on May 6, 2011)

Vertex Employee Compensation Plan (Filed With SEC on February 17, 2011)

Vertex Pharmaceuticals Non-Employee Board Compensation (Filed With SEC on February 17, 2011)

SUBORDINATED INDENTURE VERTEX PHARMACEUTICALS INCORPORATED, ISSUER AND U.S. BANK NATIONAL ASSOCIATION, TRUSTEE INDENTURE Dated as of September 28, 2010 Subordinated Debt Securities (Filed With SEC on September 29, 2010)

FIRST SUPPLEMENTAL INDENTURE BETWEEN VERTEX PHARMACEUTICALS INCORPORATED, AS ISSUER AND U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE DATED AS OF SEPTEMBER 28, 2010 ESTABLISHING THE... (Filed With SEC on September 29, 2010)

[FACE OF SECURITY] (Filed With SEC on September 29, 2010)

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 3.35% Convertible Senior Subordinated Notes due 2015 UNDERWRITING AGREEMENT (Filed With SEC on September 24, 2010)

AMENDED AND RESTATEDEMPLOYMENT AGREEMENT (Filed With SEC on May 3, 2010)

SECOND AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on May 3, 2010)

Stock Option Grant (Filed With SEC on February 19, 2010)

EMPLOYMENT AGREEMENT (Filed With SEC on February 19, 2010)

Vertex Employee Compensation Plan (Filed With SEC on February 19, 2010)

VertexPharmaceuticals Non-Employee Board Compensation (Filed With SEC on February 19, 2010)

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 11,500,000 Shares of Common Stock UNDERWRITING AGREEMENT (Filed With SEC on December 4, 2009)

ConfidentialTreatment Requested. Confidentialportions of this document have been redacted and have been separately filed with the Commission. VERTEXPHARMACEUTICALS INCORPORATED... (Filed With SEC on November 9, 2009)

(Face of Note) VERTEX PHARMACEUTICALS INCORPORATED SECURED NOTES DUE 2012 (Filed With SEC on November 9, 2009)

Confidential Treatment Requested Confidential portions of this document have been redacted and have beenseparately filed with the Commission LICENSE,DEVELOPMENT AND... (Filed With SEC on November 9, 2009)

Confidential Treatment Requested. Confidential portions of this document have been redacted and have beenseparately filed with the Commission. SECOND AMENDMENT TO... (Filed With SEC on November 9, 2009)

Confidential Treatment Requested. Confidential portions of this document have been redacted and have beenseparately filed with the Commission. (Filed With SEC on November 9, 2009)

ConfidentialTreatment Requested. (Filed With SEC on November 9, 2009)

Confidential Treatment Requested. Confidential portions of this document have been redacted and have beenseparately filed with the Commission. PURCHASE AGREEMENT REGARDING... (Filed With SEC on November 9, 2009)

Dated 10June 2009 Lease between MEPCMilton Park No. 1 Limited and MEPC Milton Park No. 2 Limited and VertexPharmaceuticals (Europe) Limited and VertexPharmaceuticals Incorporated... (Filed With SEC on August 10, 2009)

VERTEX PHARMACEUTICALS INCORPORATED AMENDED AND RESTATED 2006 STOCK and OPTION PLAN (Filed With SEC on August 10, 2009)

FIRSTAMENDMENT TO LEASE (Filed With SEC on May 11, 2009)

EIGHTH AMENDMENT TO LEASE (Filed With SEC on May 11, 2009)

SHAREPURCHASE AGREEMENT AMONG VERTEXPHARMACEUTICALS INCORPORATED, as the Parent, VERTEX PHARMACEUTICALS (CANADA) INCORPORATED, as the Purchaser, -AND - VIROCHEMPHARMA INC., as the... (Filed With SEC on March 13, 2009)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on March 13, 2009)

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 10,000,000 Shares of Common Stock UNDERWRITING AGREEMENT (Filed With SEC on February 19, 2009)

Amendment No. 3 to Employment Agreement (Filed With SEC on February 17, 2009)

Vertex Employee Compensation Plan (Filed With SEC on February 17, 2009)

Amendment No. 2 to Amended and Restated Employment Agreement (Filed With SEC on February 17, 2009)

Amendment No. 1 to Employment Agreement (Filed With SEC on February 17, 2009)

Amendment No. 1 to Amended and Restated Employment Agreement (Filed With SEC on February 17, 2009)

Form of Amendment to EmploymentAgreement and Change of Control Agreement (Filed With SEC on February 17, 2009)

AGREEMENT (Filed With SEC on February 10, 2009)

EMPLOYEE NON-DISCLOSURE, NON-COMPETITION & INVENTIONSAGREEMENT (Filed With SEC on February 10, 2009)

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 7,500,000Shares of Common Stock UNDERWRITING AGREEMENT (Filed With SEC on September 19, 2008)

INDENTURE BETWEEN VERTEXPHARMACEUTICALS INCORPORATED, AS ISSUER AND U.S. BANK NATIONALASSOCIATION, AS TRUSTEE 4.75% CONVERTIBLESENIOR SUBORDINATED NOTES DUE 2013 DATED AS... (Filed With SEC on February 25, 2008)

VERTEXPHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 6,000,000 Shares of Common Stock UNDERWRITINGAGREEMENT (Filed With SEC on February 14, 2008)

VERTEXPHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 4.75%Convertible Senior Subordinated Notes due 2013 UNDERWRITINGAGREEMENT (Filed With SEC on February 14, 2008)

VERTEX PHARMACEUTICALS INCORPORATED EMPLOYEE STOCK PURCHASE PLAN (as amended and restated May 31,2007) ARTICLE 1 PURPOSE ANDDEFINITIONS (Filed With SEC on August 9, 2007)

Confidential Treatment Requested Confidentialportions of this document have been redacted and have been separately filed with the Commission LICENSE, DEVELOPMENT... (Filed With SEC on August 9, 2007)

EMPLOYMENT AGREEMENT (Filed With SEC on August 9, 2007)

RESTRICTED STOCK AGREEMENT VERTEX PHARMACEUTICALS INCORPORATED (Filed With SEC on August 9, 2007)

CONSULTINGAGREEMENT (Filed With SEC on May 10, 2007)

ExecutiveCompensation Program (Filed With SEC on May 10, 2007)

Vertex EmployeeCompensation Plan (Filed With SEC on March 1, 2007)

VertexPharmaceuticals Non-Employee Board Compensation (Filed With SEC on March 1, 2007)

VERTEXPHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 9,100,000 Shares of Common Stock PURCHASE AGREEMENT (Filed With SEC on September 15, 2006)

VERTEXPHARMACEUTICALS INCORPORATED 2006 STOCK and OPTION PLAN (Filed With SEC on May 15, 2006)

VERTEXPHARMACEUTICALS INCORPORATED 2006 STOCK AND OPTION PLAN Formof Stock Option Grant (Filed With SEC on May 15, 2006)

VERTEXPHARMACEUTICALS INCORPORATED 2006 STOCK AND OPTION PLAN Form of RestrictedStock Award (Performance Accelerated Restricted Stock) (Filed With SEC on May 15, 2006)

Confidential TreatmentRequested. Confidential portions of thisdocument have been redacted and have been separately filed with the Commission AMENDMENT NO. 2 to RESEARCH,... (Filed With SEC on May 10, 2006)

EXCHANGEAGREEMENT (Filed With SEC on November 9, 2005)

Exchange Agreement (Filed With SEC on November 9, 2005)

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 11,750,000 Shares of Common Stock PURCHASE AGREEMENT (Filed With SEC on June 8, 2005)

VERTEX PHARMACEUTICALS INCORPORATED 1996 STOCK AND OPTION PLAN [Form of Stock Option Grant] (Filed With SEC on February 9, 2005)

VERTEX PHARMACEUTICALSINCORPORATED 1996 STOCK AND OPTION PLAN (Filed With SEC on February 9, 2005)

VERTEX PHARMACEUTICALS INCORPORATED 1996 STOCK AND OPTION PLAN (Filed With SEC on February 9, 2005)

INDENTURE BETWEEN VERTEX PHARMACEUTICALS INCORPORATED, AS ISSUER AND U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE 5% CONVERTIBLE SENIOR SUBORDINATED NOTES DUE 2011 DATED AS OF... (Filed With SEC on February 23, 2004)

Dated February 10, 2004 VERTEXPHARMACEUTICALS INCORPORATED and UBS SECURITIES LLC DEALERMANAGER AGREEMENT (Filed With SEC on February 23, 2004)

REGISTRATION RIGHTS AGREEMENT among VERTEX PHARMACEUTICALS INCORPORATED, and UBS Securities LLC as Dealer Manager Dated February 13, 2004 (Filed With SEC on February 23, 2004)

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Vertex Pharmaceuticals Inc Contracts & Agreements