SETTLEMENT AGREEMENT AND RELEASE

Release. The Parties hereby release and forever discharge one another, their present and former parents, affiliates, subsidiaries, predecessors, successors, and related entities, its present and former officers, directors, shareholders, employees (including but not limited to [***]’s former employee, [***]), partners, attorneys, affiliates, representatives, spouses, trustees, and agents, and each of such persons’ heirs, successors, assigns, executors, administrators, and beneficiaries, of and from any and all claims (including claims for costs and attorneys’ fees), damages, demands, suits, debts, actions or causes of action of any kind, whether known or unknown, suspected or unsuspected, that the Parties, or any of them, ever had or may now or hereafter own, hold, have or claim to have by reason of any matter, cause or thing whatsoever from the beginning of the world to the day of the date of this Agreement, including but not limited to any and all investments Claimant made at or through any employee or agent of [***], including but not limited to investments in [***], and any claims which are or could have been asserted by Claimant in the [***] arbitration matter entitled Vermillion, Inc. f/k/a Ciphergen Biosystems, Inc. v. [***], and identified as [***], (collectively, the “Claim”).

Section 1542 Waiver. The Parties hereby expressly waives any and all rights that they may have under the provisions of California Civil Code section 1542, which reads as follows:

Unknown Claims. It is possible that other injuries or damages not now known to the Parties will develop or be discovered, and this Agreement is expressly intended to cover and include all such injuries or damages, including all rights of action relating thereto.

Dismissal of Arbitration. Within ten (10) days of the total payment due under this Agreement by [***], Claimant shall dismiss [***] in its entirety, with prejudice.

Payment by [***]. For and in consideration of each of the terms set forth herein, [***] shall pay Claimant the total sum of $1,000,000 payable in two (2) installments as follows: $535,000 on or before March 1, 2012 and $465,000 on or before September 1, 2012. Such payments shall be made by wire transfer to the “Ackerman, Link & Sartory, P.A. Trust Account f/b/o Vermillion, Inc.,” (tax identification number 65-0668726) as follows:

Assignment of Claims Based on Released Matters. Claimant hereby transfers and assigns to [***] any and all claims, demands, and causes of action whatsoever that Claimant has or may have against any individual or entity arising out of or related to the Claim. [***] may in its own name and for its own benefit prosecute, collect, settle, compromise and grant releases on said claims, demands, and causes of action as it in its sole discretion deems advisable.

Attorneys’ Fees and Costs. Each Party shall bear its own expenses, including any costs or attorneys’ fees, incurred in connection with the Claim. Claimant is responsible for any tax liability that may be created as a result of this Agreement.

Applicable Law. This Agreement shall be construed, interpreted, governed, and enforced in accordance with the laws of the State of California.

Entire Agreement. This Agreement constitutes a binding and enforceable agreement of settlement among the Parties, and the Parties acknowledge that there are no other warranties, promises, assurances or representations of any kind, express or implied, upon which the Parties have relied in entering into this Agreement, unless expressly set forth herein. This Agreement shall not be modified except by written agreement signed by all Parties to this Agreement.

Parties Affected. This Agreement shall be binding upon and inure to the benefit of the officers, directors, shareholders, employees, partners, attorneys, affiliates, representatives, spouses, trustees, heirs, successors, and assigns of the Parties.

Warranty. Each Party warrants (a) that the person executing this Agreement on its behalf has the authority to do so; and (b) that the matters being released pursuant to this Agreement have not been assigned or otherwise transferred to any other person or entity.

Acknowledgment of Terms. The Parties have read and understand the terms of this Agreement, have consulted with their respective counsel, and understand and acknowledge the significance and consequence of each such term.

Representation by Counsel. The Parties agree that they are entering into this Agreement after having received full advice from counsel of their choosing with respect to this Agreement and all other matters related thereto.

Execution of Documents. This Agreement may be executed in counterparts, that is, all signatures need not appear on the same copy. All such executed copies shall together constitute the complete Agreement. Facsimile signatures shall for all purposes have the same effect as original signatures.

Confidentiality. The Parties agree that, other than acknowledging in response to any inquiry the fact that the Claim has been settled, Claimant shall not disclose or discuss, or cause or permit his/her counsel or anyone in privity with counsel to disclose or discuss, directly or indirectly, to any person, entity or representative thereof, who is not a Party or an employee or agent of a Party to the Claim, any of the terms of the settlement of the Claim, any documents received in connection with the Claim and/or the facts regarding the underlying controversies and disputes; provided, however, that nothing contained herein shall preclude Claimant from: (1) complying with disclosure and reporting laws applicable to public companies, (2) complying with any lawful subpoena or court order, (3) complying with any request for information or documents from any securities industry regulator or self-regulatory organization, (4) responding to any inquiry by or providing testimony to the United States Securities and Exchange Commission, any self-regulatory organization or any federal or state regulatory authority, or (5) from making disclosure of the fact and amount of this settlement to lawyers, accountants, tax

advisors, board members, shareholders, or during any 2012 quarterly earnings call as Claimant’s counsel determines is reasonably necessary to comply with applicable securities laws, rules and regulations.