Consent and Amendment, dated June 12, 2018, by and among VX3, Inc., FCMI Parent Co., the Company and VX3 (DE) LP

Exhibit 10.21

EXECUTION COPY

CONSENT AND AMENDMENT

June 12, 2018

Reference is hereby made to (a) the Agreement of Limited Partnership of VX3 (DE) LP, dated as of October 27, 2017, by and among VX 3 Inc., a corporation incorporated under the laws of Ontario, as the general partner (the “General Partner”), the parties set out in Schedule A thereto (the “Limited Partners”), and any other Persons who shall in the future execute and deliver the Partnership Agreement as additional Partners pursuant to the provisions thereof (the “Partnership Agreement”), and (b) the Services Agreement, dated as of November 6, 2017, by and between Vaccinex, Inc., a corporation incorporated under the laws of Delaware (“Vaccinex”), and VX3 (DE) LP, a limited partnership organized under the laws of Delaware (the “Partnership”) (the “Services Agreement”), each as amended by (x) the Consent and Amendment, dated as of February 28, 2018, by and among the General Partner, FCMI Parent Co., a Limited Partner (“FCMI”), and the Partnership and (y) the Consent and Amendment, dated as of May 15, 2018, by and among the General Partner, FCMI and the Partnership (the “Second Amendment”).

Following the Second Amendment, the General Partner and Joseph Rutman, as trustee, agreed that, on or about the date hereof, Joseph Rutman, as trustee, would make a Capital Contribution to the Partnership in the amount of US$2,000,000 in exchange for Limited Partner Units at the Limited Partner Purchase Price (the “June 2018 Capital Contribution”).

For purposes of Section 5.2(b) of the Partnership Agreement, the General Partner and FCMI hereby authorize and approve the June 2018 Capital Contribution. Additionally, each of the undersigned parties hereby agree and acknowledge that Schedule A to the Partnership Agreement shall be amended and restated in its entirety in the form attached hereto as Annex A to reflect the June 2018 Capital Contribution (the “Amended Schedule”). Finally, each of the undersigned parties hereby acknowledge and agree that Schedule C to the Services Agreement shall be amended to provide that US$2,000,000 be applied to the costs and expenses of Vaccinex in connection with the performance of the Services (as defined in the Services Agreement) from and after the date hereof.

All capitalized terms used but not defined herein shall have the meanings set forth in the Partnership Agreement.

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IN WITNESS WHEREOF, the undersigned have duly executed this Consent and Amendment, or have caused this Consent and Amendment to be duly executed on their behalf, as of the day and year first hereinabove set forth.

[Signature Page to Consent and Amendment]