103* Employment agreement, executed September 14, 2020, by and between uniQure Inc. and Ricardo Dolmetsch

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EMPLOYMENT AGREEMENT

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into as of September 14, 2020 (the “Effective Date”), by and between uniQure, Inc., 113 Hartwell Avenue, Lexington, MA 02421 (together with any and all of its affiliates, the “Company”) and Ricardo E. Dolmetsch Ph.D. (the “Executive”).

WITNESSETH:

WHEREAS, the Company wishes to employ President, Research & Development.

WHEREAS, Executive wishes to be employed by the Company and to serve in such capacity under the terms and conditions set forth in this Agreement.

NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein and intending to be legally bound hereby, the Company and Executive agree as follows.

1.Employment. The Company hereby agrees to employ Executive, and Executive hereby accepts such employment by the Company, as a full-time employee for the period and upon the terms and conditions contained in this Agreement. Any prior agreement related to the Executive’s employment with the Company, whether written or oral, is hereby terminated as of the Effective Date.

2.Term. Executive’s term of employment with the Company under this Agreement shall begin on the Effective Date and shall continue in force and effect from year to year unless terminated earlier in accordance with Section 19 (the “Term”).

3.Position and Duties. During the Term, Executive shall serve the Company as its President, Research & Development. Executive will be responsible for directing the research, product and clinical development of uniQure’s pipeline, reporting directly to the uniQure Chief Executive Officer (the “CEO”). Executive will perform other duties consistent with the job description and as may be customarily provided by a person in such position.

4.During the Term, Executive shall devote full business time, best efforts, skill, knowledge, attention and energies to the advancement of the Company’s business and interests and to the performance of Executive’s duties and responsibilities as an employee of the Company. Executive shall abide by the rules, regulations, instructions, personnel practices and policies of the Company and any changes therein that may be adopted from time to time by the Company. However, Executive shall be permitted to continue his current position with Stanford University as an Adjunct Professor of Neurobiology. Further, Executive shall retain all copyrights and other intellectual property rights to his academic and other writings, oral presentation materials, and other works that are created by Executive outside the scope of Executive’s employment with Company (“Executive Works”), provided that such Executive Works do not incorporate and are not derived from any intellectual property (including, without limitation, inventions, trade secrets, copyrighted works, and data), proprietary information, confidential information, written documents or other works of Company.

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5.During the Term, Executive shall not be engaged in any business activity which, in the judgment of the Company, conflicts with Executive’s duties hereunder, whether or not such activity is pursued for pecuniary advantage. Should Executive wish to provide any services to any other person or entity other than the Company or to serve on the board of directors of any other entity or organization, Executive shall submit a written request to the Company for consideration and approval by the Company, which approval shall not unreasonably be withheld. If the Company later makes a reasonable, good faith determination that Executive’s continued service on another entity’s board would be detrimental to the Company, it will give Executive thirty (30) days’ written notice that it is revoking the original approval, and Executive will resign from the applicable board within thirty (30) days after receipt of such notice. Notwithstanding the foregoing, Executive may engage in civic and charitable organizations and manage Employee’s personal and business affairs during normal business hours provided such activities do not, individually or collectively, interfere with the performance of his duties hereunder.

6.Location. Executive shall perform the services hereunder from the Company’s USA headquarters at 113 Hartwell Avenue, Lexington MA, USA; provided, however, that Executive shall be required to travel from time to time for business purposes, including, without limitation, to the Company’s facilities in Amsterdam, Netherlands.

7.Compensation and Benefits.

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8.Equity. Subject to Board of Directors approval at the next regularly scheduled uniQure N.V. Board meeting after the execution of this Agreement and commencement of employment, Executive shall be granted:

Each grant will be pursuant to uniQure N.V.’s Amended and Restated 2014 Share Incentive Plan, and the terms will otherwise reflect the standard vesting and other terms and conditions contained in the Share Incentive Plan and the Company’s standard equity grant agreements. Such option will be approved by the Board of Directors of uniQure N.V. not later than at its next regularly scheduled meeting. If the Board fails to make the grant at such regularly scheduled meeting, it shall be deemed a Good Reason event under Section 19(f) hereof. The Executive will be eligible for future equity grants pursuant to the Company’s policies and procedures. Any additional grants during the first-year of employment (not including those provided above) will be prorated based on hire date, and all future grants of equity shall be subject to the provisions of this Agreement, including, without limitation, Sections 17 (Change of Control) and 19 (Termination).

9.Retirement and Welfare Benefits. Executive is eligible to participate in any and all benefit programs that the Company establishes and makes available to its employees from time to time, provided that Executive is eligible under (and subject to all provisions of) the plan documents that govern those programs. These include medical, dental and disability insurances. Benefits are subject to change at any time in the Company’s sole discretion.

10.Paid Time Off and Holidays. Executive is eligible for 4 weeks of paid vacation per calendar year (prorated for any partial year during the term) to be taken at such times as may be approved in advance by the Company. Executive is also entitled to all paid holidays observed by the Company in the United States. Executive shall have all rights and be subject to all obligations and responsibilities with respect to paid time off and holidays as are set forth in the Company’s employee manual or other applicable policies and procedures, which may provide for benefits greater than but not less than those provided in this Agreement.

11.Expense Reimbursement. During the Term, Executive shall be reimbursed by the Company for all necessary and reasonable expenses incurred by Executive in connection with the performance of Executive’s duties hereunder (including business trips to the uniQure

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Amsterdam headquarters). Executive shall keep an itemized account of such expenses, together with vouchers and/or receipts verifying the same and submit for reimbursement on a monthly basis. Any such expense reimbursement will be made in accordance with the Company’s travel and expense policies governing reimbursement of expenses as are in effect from time to time.

12.Withholding. All amounts set forth in this Agreement are on a gross, pre-tax basis and shall be subject to all applicable federal, state, local and foreign withholding, payroll and other taxes, and the Company may withhold from any amounts payable to Executive (including any amounts payable pursuant to this Agreement) in order to comply with such withholding obligations.

13.IP and Restrictive Covenants. The Company’s agreement to enter into this Agreement is contingent upon Executive’s execution of the Company’s Confidentiality, Developments, and Restrictive Covenants Agreement, attached as Exhibit A to this Agreement. Nothing in this Agreement or the Confidentiality, Developments, and Restrictive Covenants Agreement shall prohibit or restrict Executive from initiating communications directly with, responding to any inquiry from, providing testimony before, providing confidential information to, reporting possible violations of law or regulation to, or filing a claim or assisting with an investigation directly with a self-regulatory authority or a government agency or entity, including the Equal Employment Opportunity Commission, the Department of Labor, the National Labor Relations Board, the Department of Justice, the Securities and Exchange Commission, Congress, any agency Inspector General or any other federal, state or local regulatory authority (collectively, the “Regulators”), or from making other disclosures that are protected under the whistleblower provisions of state or federal law or regulation. Executive does not need the prior authorization of the Company to engage in conduct protected by this subsection, and Executive does not need to notify the Company that Executive has engaged in such conduct. Please take notice that federal law provides criminal and civil immunity to federal and state claims for trade secret misappropriation to individuals who disclose trade secrets to their attorneys, courts, or government officials in certain, confidential circumstances that are set forth at 18 U.S.C. §§ 1833(b)(1) and 1833(b)(2), related to the reporting or investigation of a suspected violation of the law, or in connection with a lawsuit for retaliation for reporting a suspected violation of the law.

14.At-Will Employment. This Agreement shall not be construed as an agreement, either express or implied, to employ Executive for any stated term, and shall in no way alter the Company’s policy of employment at-will, under which both the Company and Executive remain free to end the employment relationship for any reason, at any time, with or without Cause or notice. Similarly, nothing in this Agreement shall be construed as an agreement, either express or implied, to pay Executive any compensation or grant Executive any benefit beyond the end of employment with the Company.

15.Conflicting Agreements. Executive acknowledges and represents that by executing this Agreement and performing Executive’s obligations under it, Executive will not breach or be in conflict with any other agreement to which Executive is a party or is bound, and that Executive is not subject to any covenants against competition or similar covenants that would affect the performance of Executive’s obligations for the Company.

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16.No Prior Representations. This Agreement and its exhibits constitute all the terms of Executive’s hire and supersedes all prior representations or understandings, whether written or oral, relating to the terms and conditions of Executive’s employment.

17.Change of Control. In the event of a Change of Control as defined below, the vesting conditions that may apply to any options, restricted shares, restricted stock units, performance stock units or other grants of equity held by Executive pursuant to this Agreement and the Company’s Amended and Restated 2014 Share Incentive Plan will be automatically waived, and all the Stock Options will be deemed to be fully exercisable commencing on the date of the Change of Control and ending on the eighteen (18) month anniversary of the Change of Control or, if earlier, the expiration of the term of such Stock Options. For purposes of this Agreement, “Change of Control” shall mean the date on which any of the following events occurs:

18.Repayment of Certain Employment Benefits. If Executive voluntarily terminates Executive’s employment with the Company for any reason or Executive is terminated by the Company for Cause in either case within the first 24 months following the Effective Date, Executive shall repay any and all amounts paid as the Sign-on Bonus (pursuant to Section 7) according to the following schedule:

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Executive expressly authorizes the Company to deduct any amounts owed by Executive to the Company pursuant to this Section from any amounts owed to Executive by the Company or any of its affiliates, including any accrued compensation or any other amounts owed by the Company or its affiliates to Executive, in the event of Executive’s termination as provided in this Section. Executive further agrees that: (1) Executive will pay to the Company any amounts owed pursuant to this Section within 30 days of the date of termination of Executive’s employment with the Company, and (2) Executive will not have any offset against, or claim for indemnification from, the Company or any of its affiliates related to any amounts owed by Executive pursuant to this Section.

19.Termination. The Term shall continue until the termination of Executive’s employment with the Company as provided below.

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with or without continuation of full compensation and benefits under this Agreement during the pendency of the proceedings;

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CEO and all or substantially all other senior management employees of the Company and that does not adversely affect Executive to a greater extent than other similarly situated employees; provided, however that such reduction may not exceed twenty (20%) percent; (iii) a material change in the geographic location at which Executive provides services to the Company (i.e., outside a radius of fifty (50) miles from Lexington, Massachusetts); or (iv) a material breach by the Company of this Agreement or any other material agreement between Executive and the Company concerning the terms and conditions of Executive’s employment, benefits or Executive’s compensation (each a “Good Reason Condition”).

“Good Reason Process” shall mean that: (i) Executive has reasonably determined in good faith that a Good Reason Condition has occurred; (ii) Executive has notified the Company in writing of the first occurrence of the Good Reason Condition within 60 days of the first occurrence of such condition; (iii) Executive has cooperated in good faith with the Company’s efforts, for a period not less than thirty (30) days following such notice (the “Cure Period”), to remedy the condition; (iv) notwithstanding such efforts, the Good Reason Condition continues to exist; and (v) Executive terminates employment within sixty (60) days after the end of the Cure Period. If the Company cures to Executive’s satisfaction (not unreasonably withheld) the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have occurred.

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a.In the case of a termination of employment during the Term pursuant to Section 19(a)(v) or (vi) above: a lump sum severance payment equal to 100% of the sum of (A) Executive’s annual Base Salary and (B) Executive’s target Bonus amount pursuant to Section 7(b) hereof (i.e., Fifty percent (50%) of Executive’s annual Base Salary);

b.In the case of a termination of employment during the Term pursuant to Section 19(a)(vii) above: a lump sum severance payment equal to 150% of the sum of (A) Executive’s annual Base Salary and (B) Executive’s target Bonus amount pursuant to Section 7(b) hereof (i.e., Fifty percent (50%) of Executive’s annual Base Salary);

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termination of employment during the Term pursuant to Section 19(a)(vii) above, the eighteen (18) month anniversary of Executive’s termination date.

To avoid duplication of severance payments, any amount paid under this subsection shall be offset against any severance amounts that may be owed by the Company to Executive pursuant to any of Company’s Change of Control guidelines as may be adopted or amended.

20.General Release of Claims. Notwithstanding any provision of this agreement, all severance payments and benefits described in Section 19 of this Agreement (except for payment of the Accrued Benefits) are conditioned upon the execution, delivery to the Company, and expiration of any applicable revocation period without a notice of revocation having been given by Executive, all by the 30th day following the termination date of a General Release of Claims by and between Executive (or Executive’s estate) and the Company in the form attached as Exhibit B to this Agreement. (In the event of Executive’s death or incapacity due to Disability, the release will be revised for signature accordingly.) Provided any applicable timing requirements set forth above have been met, the payments and benefits will be paid or provided to Executive as soon as administratively practicable (but not later than forty-five (45) days) following the date Executive signs and delivers the General Release to the Company and any applicable revocation period has expired without a notice of revocation having been given. Any severance or termination pay will be the sole and exclusive remedy, compensation or benefit due to Executive or Executive’s estate upon any termination of Executive’s employment (without limiting Executive’s tights under any disability, life insurance, or deferred compensation arrangement in which Executive participates or at the time of such termination of employment or any Option Agreements or any other equity agreements to which Executive is a party). If such 45-day period spans two calendar years, payment will be paid after such 45-day period and revocation period have expired.

21.Certain Company Remedies. Executive acknowledges that Executive’s promised services and covenants are of a special and unique character, which give them peculiar value, the loss of which cannot be reasonably or adequately compensated for in an action at law, and that, in the event there is a breach hereof by Executive, the Company will suffer irreparable harm, the amount of which will be impossible to ascertain. Accordingly, the Company shall be entitled, if it so elects, to institute and prosecute proceedings in any court of competent jurisdiction, either at law or in equity, to obtain damages for any breach of this Agreement, or to enjoin Executive from committing any act in breach of this Agreement. The remedies granted to the Company in this Agreement are cumulative and are in addition to remedies otherwise available to the Company at law or in equity.

22.Indemnification.

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directors and officers liability insurance policy under which Executive shall be included as a “Covered Person.”

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23.Miscellaneous.

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year, (iii) the reimbursement of an eligible expense be made no later than the last day of the fiscal year following the year in which the expense is incurred, and (iv) the right to reimbursement or in-kind benefits not be subject to liquidation or exchange for another benefit.

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24.Company shall reimburse Executive or otherwise pay for the costs of the defense from any claims by his former employer that the Executive’s actions pursuant to this Agreement violate the non-competition provisions of his Employment Agreement dated April 19, 2013, provided that: (i) Executive has fully disclosed to Company the nature and extent of all of

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Executive’s relevant actual or potentially competitive pre-employment activities; (ii) Executive fully complies with all reasonable requirements requested by Company to avoid a violation of Executive’s non-competition obligation or related restrictive covenants; and (iii) Executive provides to Company control of all aspects of such defense, including, without limitation, the ability to select counsel and the ability to negotiate, compromise and settle any and all such claims on reasonable terms. Executive shall not knowingly or intentionally violate any non-competition provisions or other restrictive covenants of any prior employment agreement. Executive must inform Company of any actual or potential violation of such non-competition provisions or other restrictive covenants and must cooperate with Company to implement any reasonable provisions to avoid or obviate any such actual or potential violations.

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IN WITNESS WHEREOF, the parties have executed and delivered this Agreement as of the date first above written.

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EXHIBIT A

UNIQURE, INC.

CONFIDENTIALITY, INVENTIONS, AND

RESTRICTIVE COVENANTS AGREEMENT

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This Confidentiality, Inventions, and Restrictive Covenants Agreement (the “Agreement”) is made between uniQure, Inc. (“uniQure”), and Ricardo E. Dolmetsch Ph.D. (the "Employee") (collectively, the “Parties”) in conjunction with an Employment Agreement providing additional severance and other benefits dated September 14, 2020.

In exchange for uniQure’s agreement to employ Employee in a capacity of high trust and confidence and/or in which Employee will develop or receive highly sensitive Confidential Information and in which Employee may develop customer or supplier Goodwill, and for other good and valuable consideration, including the compensation and benefits referred to herein and/or provided for in Employee’s offer letter or employment agreement, the receipt and sufficiency of which are hereby acknowledged, Employee hereby agrees as follows:

1.Employment At Will. Employee agrees that Employee remains an “at will” employee of uniQure and that Employee may terminate Employee’s employment at any time. Employee further agrees that uniQure may similarly terminate Employee’s employment at any time as per the Employment Agreement between the Parties. This agreement does not create a contract for employment for any specified duration, either expressly or by implication.

2.Subsequent Material Changes in Employment. Even though the nature of Employee’s relationship with uniQure is as an “at will” employee, the Parties have entered into this Agreement with the understanding that it is possible that Employee’s position, title, duties and responsibilities could increase, decrease, develop, evolve, or otherwise change in a material way in the future and, in light of that understanding, the Parties nevertheless intend that this Agreement shall follow Employee throughout the entire course of Employee’s or her employment with uniQure and that any such subsequent material change shall not affect either the enforceability or the validity of this Agreement.

3.Non-disclosure of Confidential Information. Employee acknowledges that, for Employee to perform Employee’s duties properly, Employee will have access to and uniQure must necessarily entrust Employee with certain proprietary and confidential business information (the "Confidential Information"). Employee agrees that, during the term of Employee’s employment with uniQure and at all times thereafter, regardless of the reason for termination of employment, Employee will not disclose any Confidential Information or use it in any way, except with prior written authorization and on behalf of uniQure, whether or not such Confidential Information is produced by Employee's own efforts.

a.For purposes of this Agreement, “Confidential Information” means all original and copies of all material, data, documents, and information in any format (including without limitation all hardcopy, softcopy, electronic, web, and computer-based information, documents, data files, records, videos, pictures, and recordings) which constitutes confidential and/or trade secret information as further defined in this Agreement and/or Massachusetts law. Examples of Confidential Information include, but are not limited to:

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b.Employee further acknowledges that the development or acquisition of such Confidential Information is the result of great effort and expense by uniQure, that the Confidential Information is critical to the survival and success of uniQure, and that the unauthorized disclosure or use of the Confidential Information would cause uniQure irreparable harm.

4.Inventions and Developments:

a.Disclosure: Employee shall promptly and fully disclose to uniQure any and all writings, inventions, products, ideas, discoveries, developments, methods, techniques, technical data, processes, formulas, improvements, know-how, biological or chemical materials, compositions and scientific or business innovations (whether or not reduced to practice and whether or not protectable under state, federal or foreign patent, copyright, trade secret or similar laws) (collectively the “Inventions”) that Employee makes, conceives, devises, invents, creates, develops or writes, either solely or jointly with others, either within or without uniQure, during the period of Employee's employment with uniQure.

b.Further Assurances: Upon and/or following disclosure of each Invention to uniQure, Employee will, during Employee's employment and at any time thereafter, at the request and cost of uniQure, sign, execute, make and do all such deeds, instruments, documents, acts and things as uniQure and its duly authorized agents may reasonably require to apply for, obtain and vest in the name of uniQure alone (unless uniQure

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otherwise directs) letters patent, copyrights or other analogous protection in any country throughout the world, including all right, title and interest in the Inventions, and when so obtained or vested to renew and restore the same; and to defend any opposition proceedings in respect of such applications and any opposition proceedings or petitions or applications for revocation of such letters patent, copyright or other analogous protection.

c.Works Made For Hire: Employee acknowledges that all written or computer coded materials manifested in documents, systems design, disks, tapes, drawings, reports, specifications, data, memoranda or otherwise prepared in whole or in part by Employee, jointly or singly, in the course of Employee's employment, whether on uniQure’s time or on Employee’s own time, including without limitation all Inventions, shall be "works made for hire" under the Copyright Act of 1976 (the "Copyright Act"), and shall be the sole property of uniQure and uniQure shall be the sole author of such works within the meaning of the Copyright Act. All such works (the “Work Product”), as well as all copies of such works in whatever medium, shall be owned exclusively by uniQure and Employee hereby expressly disclaims any and all interests in such works. If the copyright to any such work shall not be the property of uniQure by operation of law, Employee hereby and without further consideration, irrevocably assigns to uniQure all right, title and interest in such work, including all so-called "moral rights," and will assist uniQure and its nominees in every proper way, at uniQure's expense, to secure, maintain and defend for uniQure's own benefit copyrights and any extensions and renewals thereof on such work, including translations thereof in any and all countries, such work to be and to remain the property of uniQure whether copyrighted or not. If the foregoing moral rights cannot be so assigned under the applicable laws of the countries in which such rights exist, Employee hereby waives such moral rights and consents to any action of uniQure that would violate such rights in the absence of such consent. Employee warrants that no Work Product shall contain any material owned by any third party, except as disclosed to uniQure pursuant to subsection (b), and that as to any such material, Employee shall have all rights necessary to provide to uniQure the full, unrestricted benefits to such material as incorporated into the Work Product.

d.Assignment: Without in any way limiting the foregoing, Employee hereby assigns to uniQure all right, title and interest to all Inventions, including but not limited to patent rights and copyrights.

e.Power of Attorney: In the event uniQure is unable, after reasonable effort, to secure Employee's signature on any letters patent, copyright or other analogous protection relating to an Invention, whether because of Employee's physical or mental incapacity or for any other reason whatsoever, Employee hereby irrevocably designates and appoints uniQure and its duly authorized officers and agents as Employee’s agent and attorney-in-fact, to act for and in Employee’s behalf and stead to execute and file any such application or applications and to do all other lawfully permitted acts to further the prosecution thereon with the same legal force and effect as if executed by Employee.

f.Employee Developments: Employee represents that all developments, inventions, works of authorship or other intellectual property rights to which Employee claims ownership as of the date of this Agreement (the "Employee Developments"), and which the parties agree are excluded from this Agreement, are listed in Exhibit A attached

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hereto. If no such Employee Developments are listed on Exhibit A, Employee represents that there are no such Employee Developments at the time of signing this Agreement.

g.After the date hereof, Employee will promptly disclose to uniQure and uniQure agrees to receive all disclosures in confidence, any improvements, discoveries, software, designs or writing of Employee that exist, regardless of the state of completion, to determine if they shall be deemed Inventions.

5.Restrictive Covenants:

a.For the purposes of this Section:

“Competing Products and Services” means any product, process, therapy or service of any person or organization other than uniQure that is in development or has been commercialized and that involves a gene therapy or the manufacture of a gene therapy: (i) for the treatment of any disease for which uniQure has a product or therapy on the market or in any phase of development during the term of Employee’s employment with uniQure, including, without limitation, any such products in the field of cardiovascular, central nervous system, liver or metabolic disease, or (ii) using an adeno-associated virus serotype (AAV); or (iii) that otherwise is directly competitive (or, for any products, processes, therapies or services in the development stage, would be directly competitive, if marketed or sold) with any uniQure product or therapy on the market or in any phase of development during the term of Employee’s employment with uniQure, provided in all cases that such gene therapies or the manufacture of such gene therapies shall be limited to those for specific targets, indications and/or diseases for which Employee provided services pursuant to his Employment Agreement to research, develop or commercialize.

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“Competing Organization” means any legal entity, including, without limitation, any company, corporation, partnership, sole proprietorship, bureau, ministry or agency, that develops, makes, uses, sells, imports, distributes, sells Competing Products and Services or otherwise consults or assists with such activities.

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“Prohibited Activities” means any specific types of services performed by the Employee for uniQure or its affiliates at any time during the two (2) years preceding the termination of employment.

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b.Non-Solicitation and Non-Acceptance: Employee agrees that during Employee’s employment and for a period of eighteen (18) months after the termination of employment for any reason, Employee shall not directly or indirectly:

i.recruit, solicit, or hire any employee, consultant, independent contractor who performed services for uniQure, or induce or attempt to induce any such employee, consultant, or independent contractor, to reduce or discontinue Employee’s employment, contractual, or other affiliation with uniQure;

ii.contact or accept business from any individual or entity that was an actual or prospective customer or business relationship of uniQure and that Employee serviced, had contact with, or learned Confidential Information about

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during employment at uniQure, for the purpose of soliciting the sale of or selling Competing Products and Services to such individual or entity and/or to divert any portion of that individual’s or entity’s business away from uniQure.

c.Non-competition: Employee agrees that during Employee’s employment and for a period of twelve (12) months after the termination of employment (the “Non-Competition Period”), except in the case where Employee is terminated by uniQure without cause, Employee shall not directly or indirectly, perform Prohibited Activities (whether as an employee, consultant, independent contractor, member of a board of directors, or in any other capacity) to a Competing Organization within the Geographic Area assigned to Employee in Employee’s position(s) with uniQure, or where Employee provided services or had a material presence or influence, during any time within the last two (2) years of employment with uniQure. Notwithstanding the foregoing, nothing herein shall prevent Employee from becoming employed by or otherwise rendering services to a Competing Organization whose business is diversified, if the scope of Employee’s services to such Competing Organization is limited to identifiable parts, segments, entities or business units of such business that, are not engaged in providing or producing Competing Services. Employee agrees that if Employee seeks to become employed or otherwise renders services to such a Competing Organization during the restricted period, prior to Employee’s employment or rendering such services, (i) Employee shall provide uniQure with written assurance from such Competing Organization and from Employee that Employee will not render services directly or indirectly in connection with any Competing Services, and (ii) Employee receives written approval of Employee’s intended employment or rendering such services (such approval shall not be unreasonably withheld and shall be provided by uniQure within ten (10) days from receipt of the written assurances set forth in subsection (i)). uniQure may, in its sole discretion, waive all or a portion of the Non-Competition Period. uniQure and Employee mutually agree that the following consideration offered to Employee in Employee’s employment agreement supports Employee’s promises, undertakings, and obligations under this Section 5(c) regarding post-employment non-competition: the equity grants associated with Employees Employment Agreement, bonus payments and additional severance benefits, which consideration Employee acknowledges and agree is adequate, fair, reasonable, and mutually agreed upon. The “Geographic Area” assigned to Employee is worldwide.

d.Nothing contained herein shall preclude Employee from participating, directly or indirectly, as a passive investor in the securities of any publicly-traded corporation.

e.Disclosure of Agreement to Subsequent Employers: During the eighteen (18) month period following Employee’s termination of employment from uniQure for any reason, Employee agrees to disclose this Agreement to every subsequent employer by which Employee may subsequently be employed or otherwise engaged in exchange for compensation

f.Disclosure of Future Employment to uniQure. For a period of one (1) year after the termination of employment with the Company for any reason, Employee shall promptly notify the Company of any change of address, and of any subsequent employment (stating the name and address of the employer and the title and duties of the

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position) or other business activity. In the event Employee fails to comply with this paragraph the non-solicitations, non-acceptance and noncompete periods set forth in paragraphs 5(a)-(c) shall be tolled, and shall commence with the date of the entry of a preliminary injunction

g.Reasonableness of Temporal Scope: Employee agrees that the temporal restrictions set forth in this Section are fair and are reasonably required for the protection of uniQure’s legitimate business interests in light of Employee’s substantial role as an employee of uniQure.

h.Reasonableness of Geographic Scope: Employee agrees that the geographic scope on Employee’s obligations set forth in this Section is both appropriate and reasonable.

i.Tolling of Post-Employment Obligations: If it is later determined by a court of competent jurisdiction that injunctive relief is warranted to prevent Employee from engaging in certain post-employment conduct, then the restrictive periods shall be tolled for the lesser of the period of time that Employee is determined by a court of competent jurisdiction to have had already been engaging in the prohibited conduct prior to the injunction and the maximum period allowed by law. The Parties intend that uniQure shall be entitled to full restrictive periods of post-employment conduct that does not breach or threaten to breach this Agreement.

6.Specific Performance. Employee acknowledges that a breach of this Agreement will cause irreparable injury to uniQure, that uniQure's remedies at law will be inadequate in case of any such breach or threatened breach, and that uniQure will be entitled to preliminary injunctive relief, without bond, and other injunctive relief in case of any such breach or threatened breach.

7.Waivers. The waiver by uniQure or Employee of any action, right or condition in this Agreement, or of any breach of a provision of this Agreement, shall not constitute a waiver of any other occurrences of the same event.

8.Survival, Binding Effect. This Agreement shall survive the termination of Employee’s employment with uniQure regardless of the manner of such termination and shall be binding upon Employee and Employee’s heirs, executors and administrators.

9.Assignability by uniQure. This Agreement is assignable by uniQure and inures to the benefit of uniQure, its subsidiaries, affiliated corporations, successors and assignees. This Agreement, being personal, is not assignable by Employee.

10.Severability. The covenants of this Agreement are intended to be separable, and the expressions used therein are intended to refer to divisible entities. Accordingly, the invalidity of all or any part of any section of this Agreement shall not render invalid the remainder of this Agreement or of such section. If, in any judicial proceeding, any provision of this Agreement is found to be so broad as to be unenforceable, it is hereby agreed that such provision shall be interpreted to be only so broad as to be enforceable.

11.Notice of Immunity Rights. You shall not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of confidential information or a trade secret that is made in confidence to a Federal, State, or local government official or to an attorney

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solely for the purpose of reporting or investigating a suspected violation of law. You shall not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of confidential information or a trade secret that is made in a complaint or other document filed in a lawsuit or other proceeding, if such filing is made under seal. An individual who files a lawsuit for retaliation by an employer for reporting a suspected violation of law may disclose the confidential information or trade secret to the attorney of the individual and use the confidential/trade secret information in the court proceeding, provided that the individual files any document containing the confidential information or trade secret under seal and does not disclose the confidential information or trade secret, except pursuant to court order.

12.Protected Rights. Nothing contained in this Agreement limits your ability to file a charge or complaint with the Equal Employment Opportunity Commission, the National Labor Relations Board, the Occupational Safety and Health Administration, the Securities and Exchange Commission or any other federal, state or local governmental agency or commission ("Government Agencies"). You further recognize that this Agreement does not limit your ability to communicate with any Government Agencies or otherwise participate in any investigation or proceeding that may be conducted by any Government Agency, including providing documents or other information, without notice to uniQure. This Agreement does not limit your right to receive an award for information provided to any Government Agencies.

13.Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts, but not the Commonwealth’s laws concerning conflict of laws, and shall be deemed to have been made in Massachusetts.

14.Consent To Exclusive Jurisdiction/Venue. The Parties hereby consent and submit to the exclusive jurisdiction of the federal and state courts in the Commonwealth of Massachusetts, and to exclusive venue in any Massachusetts federal court and/or Massachusetts state court located in Suffolk County, for any dispute arising from this Agreement.

15.Covenant Not To Sue Outside Of Massachusetts. Employee hereby agrees that Employee will not commence, prosecute, or assist in any way another person or entity to commence or prosecute, any legal action or other proceeding (including but not limited to a declaratory judgment action) against uniQure concerning a dispute arising from or relating to this Agreement in any forum or jurisdiction other than the state and federal courts in the state of Massachusetts.

16.Right to Consult Legal Counsel. Employee acknowledges that Employee has been advised of Employee’s right to consult with legal counsel prior to signing this Agreement, and that Employee has had a full and adequate opportunity to do so.

17.Waiver of Right to Jury Trial and Punitive Damages. EACH PARTY WAIVES ANY RIGHT TO SEEK A JURY TRIAL AND TO CLAIM FOR OR RECOVER ANY PUNITIVE DAMAGES IN ANY PROCEEDING REGARDING ANY DISPUTE THAT MAY ARISE BETWEEN THEM.

18.Entire Agreement, Amendments. This Agreement constitutes the entire understanding of the parties with respect to its subject matter, supersedes any prior communication or understanding with respect thereto, and no modification or waiver of any provision hereof shall be valid unless made in writing and signed by all of the parties hereto.

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19.Return of uniQure Property and Confidential Information/Non-Deletion of Data. Upon termination of Employee’s engagement by uniQure, or at any other time upon the request of uniQure, Employee shall forthwith deliver to uniQure any and all documents, devices, equipment, keys, security passes, credit cards, hardware, data, databases, source code, object code, and data or computer programming code stored on an optical or electronic medium, and any copies thereof, relating to uniQure’s business and affairs, including all materials that are in the possession of or under the control of Employee and that incorporate any Confidential Information or any reference thereto. Employee agrees to refrain from purging or deleting data from any uniQure-owned equipment, including email systems, in connection with Employee’s termination. To the extent that Employee possesses any data belonging to uniQure on any storage media owned by Employee (for example, a home computer’s hard disk drive, portable data storage device, etc.), Employee agrees that Employee will work cooperatively with uniQure to return such data and ensure it is removed from Employee’s devices in a manner that does not adversely impact any personal data. Employee agrees not to take any steps to delete any uniQure data from any device without first obtaining uniQure’s written approval. Employee agrees to cooperate with uniQure if uniQure requests written or other positive confirmation of the return or destruction of such data from any personal storage media.

20.EMPLOYEE ACKNOWLEDGES AND AGREES THAT THE CONSIDERATION PROVIDED TO EMPLOYEE AT THE COMMENCEMENT OF EMPLOYMENT BEYOND THE EMPLOYEES BASE SALARY (INCLUDING, WITHOUT LIMITATION, ANY PROMISE OF STOCK OR OPTION GRANTS, SIGNING BONUS, OR OTHER BONUS) CONSTITUTE SUFFICIENT CONSIDERATION FOR EMPLOYEE’S AGREEMENT TO ABIDE BY THE TERMS OF THIS AGREEMENT.

21.This Agreement may be executed in multiple counterparts, each of which shall be treated as an original. Facsimile signatures shall be valid and effective for all purposes.

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EXHIBIT A

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LIST OF EMPLOYEE DEVELOPMENTS

(if none, please write the word “none” and sign below)

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None

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EXHIBIT B

GENERAL RELEASE OF CLAIMS

In exchange for the promises and benefits set forth in Section 19 of the Employment Agreement between uniQure, Inc. and Ricardo E. Dolmetsch Ph.D. made as of September 14, 2020, and to be provided to me following the Effective Date of this General Release, I, Ricardo E. Dolmetsch, on behalf of myself, my heirs, executors and assigns, hereby acknowledge, understand and agree as follows:

1.On behalf of myself and my family, heirs, executors, administrators, personal representatives, agents, employees, assigns, legal representatives, accountants, affiliates and for any partnerships, corporations, sole proprietorships, or other entities owned or controlled by me, I fully release, acquit, and forever discharge uniQure, Inc., its past, present and future officers, directors, shareholders, agents, representatives, insurers, employees, attorneys, subsidiaries, affiliated corporations, parents, and assigns (collectively, the “Releasees”), from any and all charges, actions, causes of action, claims, grievances, damages, obligations, suits, agreements, costs, expenses, attorneys’ fees, or any other liability of any kind whatsoever, suspected or unsuspected, known or unknown, which have or could have arisen out of my employment with or services performed for Releasees and/or termination of my employment with or termination of my services performed for Releasees (collectively, “Claims”), including:

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Releasees declines to employ me for any reason, it shall not be liable to me for any cause of action or damages whatsoever.

2.Release of Other Claims. I fully release, acquit, and forever discharge the Releasees from any and all other charges, actions, causes of action, claims, grievances, damages, obligations, suits, agreements, costs, expenses, attorneys’ fees or any other liability of any kind whatsoever related to my employment, my employment agreement, my termination or the business of uniQure of which I have knowledge as of the time I sign this General Release.

3.I further acknowledge that I have received payment, salary and wages in full for all services rendered in conjunction with my employment with uniQure, Inc., including payment for all wages, bonuses, and accrued, unused paid time off, and that no other compensation is owed to me except as provided herein. I specifically understand that this general release of claims includes, without limitation, a release of claims for alleged wages due, overtime or other compensation or payment including any claim for treble damages, attorneys’ fees and costs pursuant to the Massachusetts Wage Act and State Overtime Law M.G.L. c. 149, §§148, 150 et seq. and M.G.L. c. 151, §IA et seq. and I further acknowledge that I are unaware of any facts that would support a claim against the Released Parties for violation of the Fair Labor Standards Act or the Massachusetts Wage Act.

4.Notwithstanding anything to the contrary herein, nothing in this General Release shall be deemed to release any of the Releasees for: (i) any claim for the payment of compensation due under the Employment Agreement; (ii) any claim for any of the Accrued Benefits under the Employment Agreement; (iii) any claim for any separation benefit under Section 19 of the Employment Agreement including, without limitation, separation pay and accelerated vesting of stock options (as applicable and as defined in the Employment Agreement); or (iv) any rights to indemnification or coverage under a directors and officers liability insurance policy.

5.Restrictive Covenants. I acknowledge and agree that all of my obligations under the restrictive covenants in my Confidentiality, Developments, and Restrictive Covenants Agreement remain in full force and effect and shall survive the termination of my employment with the Releasees and the execution of this General Release.

6.Consultation with Attorney. I am advised and encouraged to consult with an attorney prior to executing this General Release. I acknowledge that if I have executed this General Release without consulting an attorney, I have done so knowingly and voluntarily.

7.Period for Review. I acknowledge that I have been given at least 21 days from the date I first received this General Release (or at least 45 days from the date I first received this General Release if my termination is part of a group reduction in force) during which to consider signing it.

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8.Revocation of General Release. I acknowledge and agree that I have the right to revoke my acceptance of this General Release if I notify the Releasees in writing within 7 calendar days following the date I sign it. Any revocation, to be effective, must be in writing, signed by me, and either: a) postmarked within 7 calendar days of the date I signed it and addressed to the then current address of uniQure, Inc.’s headquarters (to the attention of the CEO); orb) hand delivered within 7 days of execution of this General Release to the uniQure, Inc.’s CEO. This General Release will become effective on the 8th day after I sign it (the “Effective Date”); provided that I have not timely revoked it.

I ACKNOWLEDGE AND AGREE THAT I HAVE BEEN ADVISED THAT THE GENERAL RELEASE IS A LEGAL DOCUMENT, AND I HAVE BEEN ADVISED TO CONSULT WITH AN ATTORNEY CONCERNING THIS GENERAL RELEASE. I ACKNOWLEDGE AND AGREE THAT I HAVE CAREFULLY READ AND FULLY UNDERSTAND ALL PROVISIONS OF THIS GENERAL RELEASE AND I AM VOLUNTARILY AND KNOWINGLY SIGNING IT.

IN, WITNESS WHEREOF, I have duly executed this Agreement under seal as of the ________ day of _______[month],_________ [year].

Ricardo E. Dolmetsch Ph.D.

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