Third Amendment to Lease, dated June 19, 2019 by and between Turning Point Therapeutics, Inc., and ARE-SD Region No. 44, LLC

Landlord and Tenant are now parties to certain Lease dated as of January 19, 2016, as amended by that certain First Amendment to Lease dated as of July 11, 2016, and as further amended by that certain Second Amendment to Lease dated as of June 8, 2018 (as amended, the “Lease”).  Pursuant to the Lease, Tenant leases certain premises consisting of approximately 18,029 rentable square feet (“Premises”), consisting of (i) approximately 8,727 rentable square feet on the second floor ( “Suite 225”), and (ii) approximately 9,302 rentable square feet on the second floor (“Suite 200”), all located in that certain building located at 10628 Science Center Drive, San Diego, California (the “Building”).  The Premises are more particularly described in the Lease.  Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease.

Term.  Notwithstanding anything to the contrary contained in the Lease, the Lease Expiration Date shall occur on the Commencement Date (as defined in the New Lease) of the New Lease (“Termination Date”).  Notwithstanding the foregoing, if the New Lease terminates prior to the Commencement Date (as defined in the New Lease) of the New Lease such that the Commencement Date (as defined in the New Lease) of the New Lease never occurs, this Third Amendment shall be null and void and of no further force or effect, the Lease Expiration Date shall not be accelerated and the Lease shall continue in full force and effect.

Base Rent.  Tenant shall continue to pay, through the Termination Date, all amounts due and owing under the Lease including, without limitation, Base Rent, Operating Expenses, Tax Expenses and Utility Costs as provided under the Lease.  Such amounts shall be prorated for any partial month.

Termination and Surrender.  Tenant shall voluntarily surrender Suite 225 on or before the Termination Date.  Tenant agrees to cooperate reasonably with Landlord in all matters, as applicable, relating to (i) surrendering Suite 225 in accordance with the surrender requirements and in the condition required pursuant to the Lease except that, notwithstanding anything to the contrary contained in Section 15.2 of the Lease, delivery of a Surrender Plan with respect to Suite

225 shall occur as promptly as possible, but shall not be required to be delivered sooner than June 14, 2019, and (ii) all other matters related to restoring Suite 225 to the condition required under the Lease.  After the Termination Date, Tenant shall have no further rights of any kind with respect to Suite 225.  Nothing herein shall excuse Tenant from its obligations under the Lease prior to the Termination Date.

Brokers.  Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Third Amendment and that no Broker brought about this transaction.  Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Third Amendment.

OFAC.  Tenant and all beneficial owners of Tenant are currently (a) in compliance with and shall at all times during the Term of the Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List, or the Sectoral Sanctions Identification List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules.

Miscellaneous.