1.21 Immediate Family Member means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including, adoptive relationships, of a natural person referred to herein.
1.22 Initiating Holders means, collectively, Holders who properly initiate a registration request under this Agreement.
1.23 IPO means the Companys first underwritten public offering of its Common Stock under the Securities Act.
1.24 Key Employee means any executive-level employee (including vice-president-level positions) as well as any employee who, either alone or in concert with others, develops, invents, programs, or designs any Company Intellectual Property (as defined in the Purchase Agreement).
1.25 Longwood means Longwood Fund IV, L.P. and its Affiliates.
1.26 Major Investor means any Investor that, individually or together with such Investors Affiliates, holds at least 4,329,004 shares of Preferred Stock (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof). Notwithstanding the foregoing, Baker Bros. shall be deemed to be a Major Investor.
1.27 New Securities means, collectively, equity securities of the Company, whether or not currently authorized, as well as rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for such equity securities.
1.28 NIBR means Novartis Institutes for Biomedical Research, Inc. and its Affiliates.
1.29 Novartis means Novartis Bioventures Ltd. and its Affiliates.
1.30 Novartis Director means the Series A Director designated by Novartis pursuant to the Voting Agreement.
1.31 Person means any individual, corporation, partnership, trust, limited liability company, association or other entity.
1.32 Preferred Director means any Series A Director, Series B Director or Series C Director.
1.33 Preferred Stock means shares of the Companys Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock.