TRU-015 for the Treatment of Rheumatoid Arthritis. Rheumatoid arthritis, or RA, is estimated to affect between 2 and 2.5 million people in the United States, with approximately 100,000 new cases diagnosed each year. It is estimated that approximately 4.3 million people are affected by RA in the United States, Japan and Europe. Total worldwide sales of protein therapeutics used for the treatment of RA were $7.6 billion in 2005 and are expected to grow to $10 billion in 2010
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EX-10.25 28 v18917orexv10w25.txt EXHIBIT 10.25 Exhibit 10.25 AMENDMENT No. 9 to THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT Dated 08 January 2004 Between LONZA BIOLOGICS *** and TRUBION PHARMACEUTICALS, INC. THIS AMENDMENT No. 9 ("Ninth Amendment") is made the 31st day of October 2005 BETWEEN LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA 98121, USA (herein after referred to as the "Customer") WHEREAS A. LB and the Customer entered into a development and manufacturing services agreement (the "Agreement") dated 08 January 2004, pursuant to which LB agreed to provide Services to the Customer, and, B. The Customer now wishes LB to perform additional services under the Agreement, and, C. LB is willing to perform such additional services on the terms set out in the Agreement, and D. The parties wish to amend the Agreement in accordance with Clause 13.5 thereto. NOW THEREFORE IT IS HEREBY AGREED as follows: 1.0 STAGE 31, SHALL BE ADDED TO SCHEDULE 2 OF THE AGREEMENT TO READ AS FOLLOWS: STAGE 31 *** BACKGROUND ***. 31.1 OBJECTIVES *** 31.2 ACTIVITIES *** 31.3 DELIVERABLES 31.3.1 A copy of the summary report as prepared in activity 31.2.11 31.4 TIMESCALE Stage 31 commenced at Customer's request ***. It is estimated that Stage 31 will be complete approximately *** from commencement. -2- SCHEDULE 3 TO THE AGREEMENT SHALL BE AMENDED TO INCLUDE PROVISION FOR PAYMENT FOR THE ABOVE MENTIONED ADDITIONAL SERVICES, AS SET OUT BELOW HERETO. INVOICES FOR THESE ADDITIONAL SERVICES SHALL BE ISSUED, AND CUSTOMER PAYMENTS SHALL BE MADE *** "1. PRICE *** 2. PAYMENT FOR STAGE 31 *** upon commencement of Stage 31. *** upon completion of Stage 31." -3- SAVE AS HEREIN PROVIDED ALL OTHER TERMS AND CONDITIONS OF THE AGREEMENT SHALL REMAIN IN FULL FORCE AND EFFECT. AS WITNESS the hands of the duly authorised representatives of the parties hereto the day and year first above written. Signed for and on behalf of *** LONZA BIOLOGICS *** ---------------------------------------- *** ---------------------------------------- TITLE Signed for and on behalf of /s/ Kendall Mohler TRUBION PHARMACEUTICALS, INC ---------------------------------------- Senior VP, Reseach & Development TITLE
