Tobira Therapeutics, Inc. Contracts & Agreements

AGREEMENT AND PLAN OF MERGER among: TOBIRA THERAPEUTICS,INC., a Delaware corporation; ALLERGAN HOLDCO US, INC., a Delaware corporation; and SAPPHIRE ACQUISITION CORP., a Delaware... (Filed With SEC on September 20, 2016)

Cenicriviroc: LICENSE AGREEMENT TOBIRA THERAPEUTICS, INC. and Dong-A ST Co., Ltd. Dated as of April 11, 2016 (Filed With SEC on May 9, 2016)

EVOGLIPTIN: LICENSE AGREEMENT Dong-A ST Co., Ltd. and TOBIRA THERAPEUTICS, INC. Dated as of April 11, 2016 (Filed With SEC on May 9, 2016)

INDEMNITY AGREEMENT (Filed With SEC on August 11, 2015)

TOBIRA THERAPEUTICS, INC. 2007 STOCK PLAN (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. 2010 Stock Plan Adopted on February 25, 2010 TABLE OF CONTENTS (Filed With SEC on August 11, 2015)

TOBIRA THERAPEUTICS, INC. 2013 EQUITY COMPENSATION PLAN (As Amended and Restated Effective May15, 2015) (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc . 701 Gateway Blvd, Suite 200 South San Francisco, CA, 94080 March17, 2014 (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. 701 Gateway Blvd., Suite 200 South San Francisco, CA, 94080 March24, 2014 (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. 198 US HIGHWAY 9 NORTH, SUITE 200 MANALAPAN, NJ 07726 (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. April29, 2014 (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. 701 Gateway Blvd, Suite 200 South San Francisco, CA 94080 February13, 2014 (Filed With SEC on August 11, 2015)

WARRANT TO PURCHASE STOCK (Filed With SEC on August 11, 2015)

TOBIRA THERAPEUTICS, INC. 198 ROUTE 9 NORTH, SUITE 200 MANALAPAN, NJ 07726 (Filed With SEC on August 11, 2015)

OFFICE LEASE BY AND BETWEEN DWF III GATEWAY, LLC, a Delaware limited liability company, as Landlord And TOBIRA THERAPEUTICS, INC., a Delaware corporation, as Tenant For Leased... (Filed With SEC on August 11, 2015)

LOAN AND SECURITY AGREEMENT (Filed With SEC on August 11, 2015)

WARRANT TO PURCHASE STOCK (Filed With SEC on August 11, 2015)

CONSULTING AGREEMENT (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. Management Cash Incentive Plan (As Adopted Effective May 15, 2015) TABLE OF CONTENTS (Filed With SEC on August 11, 2015)

CONSULTING AGREEMENT (Filed With SEC on August 11, 2015)

Tobira Therapeutics, Inc. Compensation Program for Non-Employee Directors Effective as of July 2015 (Filed With SEC on August 11, 2015)

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on August 11, 2015)

License Agreement byand between Takeda Pharmaceutical Company Limited and TobiraTherapeutics, Inc. Dated August 1st, 2007 Confidential (Filed With SEC on June 18, 2015)

Amendment (Filed With SEC on June 18, 2015)

TOBIRA THERAPEUTICS, INC. MANAGEMENT CASH INCENTIVE PLAN (AS ADOPTED EFFECTIVE MAY 15, 2015) TABLE OF CONTENTS (Filed With SEC on May 20, 2015)

TOBIRA THERAPEUTICS, INC. 2010 STOCK PLAN ADOPTED ON FEBRUARY 25, 2010 TABLE OF CONTENTS (Filed With SEC on May 20, 2015)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on May 7, 2015)

PURCHASE AGREEMENT (Filed With SEC on May 7, 2015)

This Separation and General Release Agreement must be executed and delivered to Employer (Attn: Cathy Hall, Human Resources Manager) not laterthan February 27, 2015. SEPARATION... (Filed With SEC on February 12, 2015)

AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER AND REORGANIZATION (Filed With SEC on January 23, 2015)

SUPPORT AGREEMENT (Filed With SEC on January 15, 2015)

Lock-Up Agreement January 14, 2015 (Filed With SEC on January 15, 2015)

AGREEMENT AND PLAN OF MERGER AND REORGANIZATION BY AND AMONG REGADO BIOSCIENCES,INC., LANDMARK MERGER SUB INC., TOBIRA THERAPEUTICS, INC. ANDWITH RESPECT TO SECTION 5.14, BRENT... (Filed With SEC on January 15, 2015)

SUPPORT AGREEMENT (Filed With SEC on January 15, 2015)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on December 5, 2014)

[# of firm shares] Shares TOBIRA THERAPEUTICS, INC. Common Stock UNDERWRITINGAGREEMENT (Filed With SEC on July 23, 2014)

INDEMNITY AGREEMENT (Filed With SEC on July 23, 2014)

Signature(s) Guaranteed: Medallion Guarantee Stamp (Filed With SEC on July 21, 2014)

TOBIRA THERAPEUTICS, INC. 2014 EQUITY INCENTIVE PLAN (AS ADOPTED ON MAY 21, 2014) TOBIRA THERAPEUTICS, INC. 2014 EQUITY INCENTIVE PLAN (Filed With SEC on July 21, 2014)

CONSULTING AGREEMENT (Filed With SEC on July 21, 2014)

TOBIRA THERAPEUTICS, INC. MANAGEMENT CASH INCENTIVE PLAN (AS ADOPTED EFFECTIVE JULY 15, 2014) TABLE OF CONTENTS (Filed With SEC on July 21, 2014)

LOAN AND SECURITY AGREEMENT (Filed With SEC on July 1, 2014)

WARRANT TO PURCHASESTOCK (Filed With SEC on July 1, 2014)

TOBIRA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTORS RIGHTS AGREEMENT TABLE OF CONTENTS (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 2007 STOCK PLAN (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 2010 STOCK PLAN ADOPTED ON FEBRUARY 25, 2010 TABLE OF CONTENTS (Filed With SEC on June 23, 2014)

License Agreement byand between Takeda Pharmaceutical Company Limited and TobiraTherapeutics, Inc. Dated August 1st, 2007 Confidential (Filed With SEC on June 23, 2014)

Amendment (Filed With SEC on June 23, 2014)

SUBLEASEAGREEMENT (Filed With SEC on June 23, 2014)

CONSENT TO SUBLEASE (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 701 GATEWAY BLVD., SUITE 200 SOUTH SAN FRANCISCO, CA, 94080 March 17, 2014 (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 701 GATEWAY BLVD., SUITE 200 SOUTH SAN FRANCISCO, CA, 94080 March 24, 2014 (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 198 US HIGHWAY 9 NORTH, SUITE 200 MANALAPAN, NJ 07726 (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. April 29, 2014 (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 701 Gateway Blvd, Suite 200 SouthSan Francisco, CA 94080 February 13, 2014 (Filed With SEC on June 23, 2014)

CONSULTING AGREEMENT (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. LOAN AND SECURITY AGREEMENT (Filed With SEC on June 23, 2014)

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on June 23, 2014)

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on June 23, 2014)

WARRANT TO PURCHASE STOCK (Filed With SEC on June 23, 2014)

TOBIRA THERAPEUTICS, INC. 198 ROUTE 9 NORTH, SUITE 200 MANALAPAN, NJ 07726 (Filed With SEC on June 23, 2014)

OFFICE LEASE BY ANDBETWEEN DWF III GATEWAY, LLC, a Delaware limited liability company, as Landlord And TOBIRA THERAPEUTICS, INC., a Delaware corporation, as Tenant For... (Filed With SEC on June 23, 2014)

REGADO BIOSCIENCES, INC. 2013 EQUITY COMPENSATION PLAN (Filed With SEC on June 17, 2014)

EMPLOYMENT AGREEMENT (Filed With SEC on May 23, 2014)

OFFICE LEASE Between 106 Allen Road LLC, Landlord, and Regado Biosciences, Inc. Tenant Dated:April 30, 2014 REFERENCE DATA (Filed With SEC on May 5, 2014)

EMPLOYMENT AGREEMENT (Filed With SEC on May 1, 2014)

10,000,000 Shares REGADO BIOSCIENCES, INC. Common Stock UNDERWRITING AGREEMENT (Filed With SEC on April 11, 2014)

[ ] Shares REGADO BIOSCIENCES, INC. Common Stock UNDERWRITING AGREEMENT (Filed With SEC on April 3, 2014)

[SIGNATURE PAGE FOLLOWS] (Filed With SEC on March 21, 2014)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on January 31, 2014)

AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT (Filed With SEC on December 23, 2013)

EMPLOYMENTAGREEMENT (Filed With SEC on December 9, 2013)

[5,000,000] Shares REGADO BIOSCIENCES, INC. Common Stock UNDERWRITING AGREEMENT (Filed With SEC on June 18, 2013)

[Number of Shares] REGADO BIOSCIENCES, INC. Common Stock UNDERWRITING AGREEMENT (Filed With SEC on May 29, 2013)

INDEMNIFICATION AGREEMENT (Filed With SEC on May 24, 2013)

REGADO BIOSCIENCES, INC. 2013 EQUITY COMPENSATION PLAN (Filed With SEC on May 24, 2013)

NONQUALIFIED STOCK OPTION GRANT AGREEMENT REGADO BIOSCIENCES, INC. (Filed With SEC on May 24, 2013)

RESTRICTED STOCK AWARD AGREEMENT REGADO BIOSCIENCES, INC. (Filed With SEC on May 24, 2013)

REGADO BIOSCIENCES, INC. 2013 EMPLOYEE STOCK PURCHASE PLAN (Filed With SEC on May 24, 2013)

WARRANT TO PURCHASE STOCK (Filed With SEC on May 17, 2013)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on May 17, 2013)

REGADO BIOSCIENCES, INC. LOAN AND SECURITY AGREEMENT (Filed With SEC on May 17, 2013)

CLINICAL DEVELOPMENT AND COLLOBORATION AGREEMENT (Filed With SEC on May 17, 2013)

REGADO BIOSCIENCES, INC. TERMINATION AGREEMENT (Filed With SEC on May 17, 2013)

OFFICE LEASE AGREEMENT BY AND BETWEEN KEYSTONE 430 TT LLC (AS LANDLORD) AND REGADO BIOSCIENCES, INC. (AS TENANT) 430 Davis Drive Durham, North Carolina (Filed With SEC on May 17, 2013)

REGADO BIOSCIENCES, INC. THIRD AMENDED AND RESTATED INVESTORSRIGHTS AGREEMENT (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. THIRD AMENDED AND RESTATED REGISTRATION RIGHTSAGREEMENT (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. STOCK PURCHASE WARRANT (Filed With SEC on April 29, 2013)

WARRANT TO PURCHASE[ ] SHARES OF CAPITAL STOCK OF REGADO BIOSCIENCES, INC. The transferability of this Warrant is restricted as provided in Section 5 and in the Exercise Notice... (Filed With SEC on April 29, 2013)

INDEMNIFICATION AGREEMENT (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. 2004 EQUITY COMPENSATION PLAN Effective as of November 19, 2004 REGADO BIOSCIENCES, INC. 2004 EQUITY COMPENSATION PLAN ARTICLE IGENERAL PROVISIONS (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. INCENTIVE STOCK OPTION AGREEMENT Under the REGADO BIOSCIENCES, INC. 2004 EQUITY COMPENSATION PLAN (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. NONQUALIFIED STOCK OPTION AGREEMENT Under the REGADO BIOSCIENCES, INC. 2004 EQUITY COMPENSATION PLAN (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. SERIES D PREFERRED STOCK PURCHASE AGREEMENT (Filed With SEC on April 29, 2013)

AMENDMENT NO. 1 TO SERIES D PREFERRED STOCK PURCHASE AGREEMENT (Filed With SEC on April 29, 2013)

LOAN AND SECURITY AGREEMENT (Filed With SEC on April 29, 2013)

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on April 29, 2013)

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on April 29, 2013)

THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT (Filed With SEC on April 29, 2013)

CONVERTIBLE NOTE PURCHASE AGREEMENT (Filed With SEC on April 29, 2013)

Form of Note (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. SERIES E PREFERRED STOCK PURCHASE AGREEMENT (Filed With SEC on April 29, 2013)

TECHNOLOGY TRANSFER AGREEMENT Dated December 18, 2012 By and Between DOMAIN RUSSIA INVESTMENTS LIMITED And REGADOBIOSCIENCES, INC. (Filed With SEC on April 29, 2013)

ASSIGNMENT AND ASSUMPTION AGREEMENT (Filed With SEC on April 29, 2013)

LICENSE AGREEMENT (Filed With SEC on April 29, 2013)

FIRST AMENDMENT TO LICENSE AGREEMENT (Filed With SEC on April 29, 2013)

LICENSE, MANUFACTURING AND SUPPLY AGREEMENT (Filed With SEC on April 29, 2013)

REGADO BIOSCIENCES, INC. WAIVER OF CERTAIN CONDITIONS TO CLOSING OF SECOND TRANCHE OF THE INITIAL CLOSING AND AGREEMENT TO REVISED CONDITIONS MARCH 22, 2013 W I T N E S S E T H: (Filed With SEC on April 29, 2013)

AGILENT SUPPLY AND SERVICE AGREEMENT (Filed With SEC on April 29, 2013)

Amendment #1 (Filed With SEC on April 29, 2013)

Clinical Supply Agreement (Filed With SEC on April 29, 2013)

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Tobira Therapeutics, Inc. Contracts & Agreements