Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.6 AMENDMENT NO. 1 TO SUPPLY AGREEMENT By and between Teva API, Inc. and The Medicines Company

THIS AMENDMENT NO. 1 (“First Amendment”) to the Supply Agreement, as defined below, is made and entered into as of February 13, 2012 (the “Effective Date”) by and between Teva API, Inc. (formerly known as Plantex USA Inc.), a New Jersey corporation with offices at 400 Chestnut Ridge Road, Woodcliff Lake, NJ 07670 (“TEVA”) and The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”). TEVA and MDCO are sometimes together referred to herein as the “Parties” and separately as a “Party.”

WHEREAS, TEVA and MDCO entered into a certain Supply Agreement dated September 30, 2011, (the “Supply Agreement”);

WHEREAS, the Parties desire to enter into this First Amendment to make certain modifications to the terms and conditions of the Supply Agreement.

NOW, THEREFORE, in consideration of the foregoing premises and the mutual agreements set forth below, and other good and valuable consideration the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows:

amended and supplemented in this First Amendment, all provisions of the Supply Agreement shall remain fully valid and in full force and effect. This First Amendment shall be binding upon and inure to the benefit of the Parties hereto. This First Amendment may be executed in any member of counterparts, with each executed counterpart constituting an original, but all together one and the same instrument.

IN WITNESS HEREOF, the Parties have caused this Amendment No. 1 to be executed by their duly authorized representatives as of the Amendment No. 1 Effective Date.

By:    /s/ Henit Lapid            

Name: Henit Lapid Ben Ari

Title: Director, Sales and Marketing

By:    /s/ Kerri Wood            

Name: Kerri Wood

Title: Vice President

By:    /s/ Anthony Flammia            

Name:    /s/ Anthony Flammia            

Title:    Global Vice President Manufacturing & Supply

(*) Upon completion of the 'Results' column this document becomes a certificate of analysis End of C.O.A.

(**) This document was signed electronically and this is the manifestation of the electronic signature.