The Medicines Company Contracts & Agreements

Supplemental Indenture, dated as of January 6, 2020, to the indenture, dated as of January 13, 2015, between the Company and the Trustee (Filed With SEC on January 6, 2020)

Supplemental Indenture, dated as of January 6, 2020, to the indenture, dated as of June 10, 2016, between the Company and the Trustee (Filed With SEC on January 6, 2020)

Supplemental Indenture, dated as of January 6, 2020, to the indenture, dated as of December 18, 2018, between the Company and the Trustee (Filed With SEC on January 6, 2020)

Agreement and Plan of Merger, dated as of November 23, 2019, by and among The Medicines Company, Novartis AG and Medusa Merger Corporation (Filed With SEC on November 25, 2019)

Underwriting Agreement, dated as of June 25, 2019, by and among the Company, Goldman Sachs & Co. LLC and J.P. Morgan Securities LLC (Filed With SEC on June 28, 2019)

Separation Agreement, dated March 15, 2019, between Christopher Cox and the registrant (Filed With SEC on April 26, 2019)

Indenture (including Form of Notes), dated as of December 18, 2018, by and between The Medicines Company and Wells Fargo Bank, National Association, a national banking... (Filed With SEC on December 18, 2018)

Employment Agreement, dated December 10, 2018, by and between Mark Timney and The Medicines Company (Filed With SEC on December 11, 2018)

Severance Agreement, dated December 10, 2018, by and between Mark Timney and The Medicines Company (Filed With SEC on December 11, 2018)

Form of performance stock option agreement under 2013 Stock Incentive Plan (Filed With SEC on August 2, 2018)

Tenth Amendment to Second Amended and Restated Distribution Agreement, effective April 30, 2018, by and between the registrant and Integrated Commercialization Solutions LLC,... (Filed With SEC on August 2, 2018)

Ninth Amendment to Second Amended and Restated Distribution Agreement, effective October 3, 2017, by and between the registrant and Integrated Commercialization Solutions LLC,... (Filed With SEC on March 1, 2018)

Amendment, dated November 14, 2017, of the Amended and Restated Employment Agreement between The Medicines Company and Clive Meanwell, dated May 26, 2016 (Filed With SEC on March 1, 2018)

Purchase and Sale Agreement, dated as of November 28, 2017, by and among The Medicines Company and Melinta Therapeutics, Inc (Filed With SEC on December 4, 2017)

Amendment No. 2 to the Supply and Distribution Agreement, dated July 1, 2017, by and between registrant and Sandoz Inc (Filed With SEC on November 9, 2017)

Exhibit 10.16 Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions. SECOND AMENDMENT TO CONTRACT... (Filed With SEC on March 1, 2017)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. OTHER TRANSACTION AGREEMENT (OTA) BETWEEN THE... (Filed With SEC on October 27, 2016)

THE MEDICINES COMPANY AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of June 10, 2016 2.75% Convertible Senior Notes due 2023 (Filed With SEC on June 10, 2016)

JPMorgan Chase Bank, National Association Organised under the laws of the United States as a National Banking Association. Main Office 1111 Polaris Parkway, Columbus, Ohio 43240... (Filed With SEC on June 10, 2016)

AMENDMENT NO. 3 TO THE MEDICINES COMPANY 2013 STOCK INCENTIVE PLAN (Filed With SEC on June 1, 2016)

AMENDMENT NO. 1 TO THE MEDICINES COMPANY 2010 EMPLOYEE STOCK PURCHASE PLAN (Filed With SEC on June 1, 2016)

AMENDED AND RESTATED EMPLOYMENT AGREEMENT (Filed With SEC on June 1, 2016)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. (Filed With SEC on May 13, 2016)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Triple asterisks denote omissions. (Filed With SEC on May 9, 2016)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions.Exhibit 10.21 AMENDMENT TO CONTRACT MANUFACTURING... (Filed With SEC on February 29, 2016)

FIRST AMENDMENT TO CHEMILOG DEVELOPMENT AND SUPPLY AGREEMENT (Filed With SEC on February 29, 2016)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions.Exhibit 10.34 SECOND AMENDMENT TO CHEMILOG... (Filed With SEC on February 29, 2016)

Confidential Materials omitted and filed separately with the (Filed With SEC on February 3, 2016)

INDEMNITY AGREEMENT (Filed With SEC on December 23, 2015)

SUPPLY AND DISTRIBUTION AGREEMENT (Filed With SEC on November 9, 2015)

AMENDMENT NO. 2 TO SUPPLY AGREEMENT By and between Teva API Inc. and The Medicines Company (Filed With SEC on November 9, 2015)

INVESTMENT AGREEMENT (Filed With SEC on August 31, 2015)

AMENDMENT NO. 2 TO THE MEDICINES COMPANY 2013 STOCK INCENTIVE PLAN (Filed With SEC on June 2, 2015)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions. SEVENTH AMENDMENT TO SECOND AMENDED AND RESTATED... (Filed With SEC on May 5, 2015)

Type of FeeAmount of CompensationAnnual retainer for board members$55,000Additional annual retainer for lead director$10,000Compensation for each board meeting attended in excess... (Filed With SEC on May 5, 2015)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions. (Filed With SEC on March 2, 2015)

SECOND AMENDMENT TO THE CONSULTING AGREEMENT (Filed With SEC on March 2, 2015)

THIRD AMENDMENT TO THE CONSULTING AGREEMENT (Filed With SEC on March 2, 2015)

THE MEDICINES COMPANY AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of January 13, 2015 2.50% Convertible Senior Notes due 2022 (Filed With SEC on January 13, 2015)

AMENDMENT NO. 1 TO THE MEDICINES COMPANY 2013 STOCK INCENTIVE PLAN (Filed With SEC on August 4, 2014)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions. (Filed With SEC on May 7, 2014)

FIRST AMENDMENT TO GLOBAL COLLABORATION AGREEMENT (Filed With SEC on March 3, 2014)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. SECOND AMENDMENT TO GLOBAL COLLABORATION... (Filed With SEC on March 3, 2014)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. AGREEMENT AND PLAN OF MERGER by and among THE... (Filed With SEC on December 6, 2013)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Double asterisks denote omissions. Dated October 25 2004 (1) Quadrant Drug Delivery... (Filed With SEC on November 5, 2013)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. FOURTH AMENDMENT TO SECOND AMENDED AND RESTATED... (Filed With SEC on November 5, 2013)

FIFTH AMENDMENT TO SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT (Filed With SEC on November 5, 2013)

THE MEDICINES COMPANY 5,785,123 Shares of Common Stock Underwriting Agreement (Filed With SEC on August 15, 2013)

THE MEDICINES COMPANY 2013 STOCK INCENTIVE PLAN (Filed With SEC on August 9, 2013)

THE MEDICINES COMPANY Non-statutory Stock Option Agreement Granted Under 2013 Stock Incentive Plan (Filed With SEC on August 9, 2013)

THE MEDICINES COMPANY Non-statutory Stock Option Agreement Under 2013 Stock Incentive Plan (Filed With SEC on August 9, 2013)

THE MEDICINES COMPANY Restricted Stock Agreement Granted Under 2013 Stock Incentive Plan (Filed With SEC on August 9, 2013)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. SHARE PURCHASE AGREEMENT BY AND AMONG THE... (Filed With SEC on August 7, 2013)

Exhibit 10.1Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. (Filed With SEC on May 10, 2013)

Exhibit 10.2Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. (Filed With SEC on May 10, 2013)

Type of FeeAmount of CompensationAnnual retainer for board members$55,000Additional annual retainer for lead director$10,000Attendance for each board meeting attended in... (Filed With SEC on March 1, 2013)

AMENDMENT TO THE CONSULTING AGREEMENT (Filed With SEC on March 1, 2013)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. AGREEMENT AND PLAN OF MERGER by and among THE... (Filed With SEC on January 10, 2013)

Exhibit 10.1Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. (Filed With SEC on November 9, 2012)

Exhibit 10.2 CONSULTING AGREEMENT (Filed With SEC on November 9, 2012)

Exhibit 10.1Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. SEVERANCE AGREEMENT AND FULL AND FINAL... (Filed With SEC on August 9, 2012)

Exhibit 10.2Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. (Filed With SEC on August 9, 2012)

Exhibit 10.3Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. THIRD AMENDMENT TO SECOND AMENDED AND... (Filed With SEC on August 9, 2012)

THE MEDICINES COMPANY AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of June 11, 2012 1.375% Convertible Senior Notes due 2017 (Filed With SEC on June 14, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.1 (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.2 LICENSE AGREEMENT BY AND AMONG THE... (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.3 (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.4 (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.5 (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with theSecurities and Exchange Commission. Asterisks denote omissions. Exhibit 10.6 AMENDMENT NO. 1 TO SUPPLY AGREEMENT By and... (Filed With SEC on May 10, 2012)

Confidential Materials omitted and filed separately with the Securities and Exchange Commissions. Asterisks denote omissions. Manufacturing Services Agreement March 30, 2011 (Filed With SEC on November 9, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SETTLEMENT AGREEMENT BY AND AMONG THE MEDICINES... (Filed With SEC on November 9, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. LICENSE AGREEMENT BY AND AMONG THE MEDICINES COMPANY... (Filed With SEC on November 9, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SUPPLY AGREEMENT (the "Agreement") entered into on... (Filed With SEC on November 9, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. FIRST AMENDMENT TO SECOND AMENDED AND RESTATED... (Filed With SEC on November 9, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SECOND AMENDMENT TO SECOND AMENDED AND RESTATED... (Filed With SEC on November 9, 2011)

FOURTH AMENDMENT TO LEASE (Filed With SEC on August 2, 2011)

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions SETTLEMENT AGREEMENT AND RELEASE (Filed With SEC on May 10, 2011)

EX-101 INSTANCE DOCUMENT (Filed With SEC on March 15, 2011)

EX-101 INSTANCE DOCUMENT (Filed With SEC on November 9, 2010)

Current assets (Filed With SEC on August 9, 2010)

Product or Product (Filed With SEC on March 16, 2010)

Current assets (Filed With SEC on November 9, 2009)

Current assets (Filed With SEC on August 10, 2009)

Current assets (Filed With SEC on May 11, 2009)

EX-10.18: LEASE (Filed With SEC on March 2, 2009)

EX-10.24: FORM OF AMENDED AND RESTATED MANAGEMENT SEVERANCE AGREEMENT (Filed With SEC on March 2, 2009)

EX-10.25: FORM OF AMENDED AND RESTATED MANAGEMENT SEVERANCE AGREEMENT (Filed With SEC on March 2, 2009)

EX-10.38: AMENDMENT NO.2 TO LICENSE AGREEMENT (Filed With SEC on March 2, 2009)

EX-10.40: AMENDMENT TO LEASE (Filed With SEC on March 2, 2009)

EX-10.42: SEVERANCE AGREEMENT (Filed With SEC on March 2, 2009)

AGREEMENT AND PLAN OF MERGER by and among The Medicines Company, Boxford Subsidiary Corporation and Targanta Therapeutics Corporation Dated as of January 12, 2009 (Filed With SEC on January 14, 2009)

Confidential Materials omittedand filed separately with the Securities and ExchangeCommission. Asterisks denote omissions. PUBLIC DEED WILMERHALE Sale and Purchase Agreement... (Filed With SEC on November 10, 2008)

Summary of Annual Cash Bonus Plan (Filed With SEC on August 11, 2008)

Summary of The Medicines Company Board of Directors Compensation (Filed With SEC on May 9, 2007)

CONSULTING AGREEMENT (Filed With SEC on May 9, 2007)

ConfidentialMaterials omitted and filed separately with the Securities and Exchange Commission.Asterisks denote omissions. AMENDMENT NO. 1 TO LICENSE AGREEMENT (Filed With SEC on August 8, 2006)

THE MEDICINES COMPANY 2004 STOCK INCENTIVE PLAN(1) (Filed With SEC on August 8, 2006)

THE MEDICINES COMPANY 2000 EMPLOYEE STOCK PURCHASE PLAN1 (Filed With SEC on August 8, 2006)

THE MEDICINESCOMPANY Restricted Stock Agreement Granted Under 2004 Stock Incentive Plan (Filed With SEC on May 10, 2006)

The Medicines Company 8 Campus Drive Parsippany, New Jersey 07054 December 23, 2005 (Filed With SEC on March 15, 2006)

THIRD AMENDMENT TO LEASE (Filed With SEC on March 14, 2005)

THE MEDICINES COMPANY Nonstatutory Stock Option Agreement Under 2004 Stock Incentive Plan (Filed With SEC on March 14, 2005)

APPENDIX 1 DEFINED TERMS (Filed With SEC on March 14, 2005)

CONSULTING AGREEMENT (Filed With SEC on March 14, 2005)

Summary ofThe Medicines Company Board of Director Compensation (Filed With SEC on March 14, 2005)

Development and SupplyAgreement (Filed With SEC on November 5, 2004)

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on November 5, 2004)

THE MEDICINES COMPANY 2004 STOCK INCENTIVE PLAN (Filed With SEC on August 6, 2004)

THE MEDICINES COMPANY Nonstatutory StockOption Agreement Under 2004 Stock Incentive Plan (Filed With SEC on August 6, 2004)

THE MEDICINES COMPANY Nonstatutory StockOption Agreement Under 1998 Stock Incentive Plan (Filed With SEC on August 6, 2004)

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The Medicines Company Contracts & Agreements