THIRD AMENDMENT TO ASSET PURCHASE AGREEMENT

Exhibit 10.14.4

THIRD AMENDMENT TO ASSET PURCHASE AGREEMENT

THIS THIRD AMENDMENT TO ASSET PURCHASE AGREEMENT (this “Amendment”) is entered into and effective as of December 3, 2007 by and among IBR-BYR L.L.C., a Louisiana limited liability company (“IBR BYR”), International BioResources, L.L.C., a Louisiana limited liability company (the “Parent”), IBR Plasma Centers, L.L.C., a Louisiana limited liability company (“IBR PC” and, collectively with IBR BYR and the Parent, the “Acquired Asset Entities”), Talecris Biotherapeutics Holdings Corp., a Delaware corporation (“Holdings”), and Talecris Plasma Resources, Inc., a Delaware corporation (the “Buyer”). The Buyer, Holdings and the Acquired Asset Entities sometimes are referred to collectively herein as the “Parties.”

WHEREAS, the Buyer, Holdings and the Acquired Asset Entities are parties to that certain Asset Purchase Agreement dated October 31, 2006, as amended by the First Amendment to Asset Purchase Agreement dated November 18, 2006 and the Second Amendment to Asset Purchase Agreement dated June 9, 2007 (as so amended, the “Agreement”), pursuant to which, subject to the terms and conditions of the Agreement, the Buyer agreed to purchase the Acquired Assets and assume the Assumed Liabilities from the Acquired Asset Entities and the Acquired Asset Entities agreed to sell the Acquired Assets and transfer the Assumed Liabilities to the Buyer; and

WHEREAS, the Parties wish to amend the Agreement with respect to the matters set forth herein.

NOW, THEREFORE, in consideration of the terms and conditions, premises and the other mutual covenants contained herein, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto, intending to be legally bound, hereby agree as follows:

1.          Definitions. All capitalized terms used but not otherwise defined herein shall have the meanings given such terms in the Agreement.

2.          Amendment to Section 8(f). Section 8(f) of the Agreement is hereby amended by adding the following Section 8(f)(iv) at the end of Section 8(f):

(iv)          Notwithstanding anything in this Section 8 to the contrary, no Party shall be entitled to assert any indemnification claim or recover indemnification with respect to any Adverse Consequences under this Agreement, except with respect to any and all Third Party Claims pursuant to Section 8(d) of this Agreement.

3.          Governing Law. This Amendment shall be governed by and construed in accordance with the domestic laws of the State of New York without giving effect to any choice or conflict of law provision or rule (whether of the State of New York or any other jurisdiction) that would cause the application of the laws of any jurisdiction other than the State of New York.