Synthetic Biologics, Inc. Contracts & Agreements

Amendment No. 2 to the Theriva Biologics, Inc. 2020 Stock Incentive Plan (Filed With SEC on November 1, 2024)

Placement Agency Agreement, dated as of September 26, 2024, by and between Theriva Biologics, Inc. and A.G.P./Alliance Global Partners, as placement agent (Filed With SEC on September 30, 2024)

Form of Common Warrant (Filed With SEC on September 30, 2024)

Form of Pre-Funded Warrant (Filed With SEC on September 30, 2024)

Form of Securities Purchase Agreement (Filed With SEC on September 30, 2024)

Form of Placement Agency Agreement (Filed With SEC on September 10, 2024)

Form of Common Warrant (Filed With SEC on September 10, 2024)

Form of Pre-Funded Warrant (Filed With SEC on September 10, 2024)

Form of Securities Purchase Agreement (Filed With SEC on September 10, 2024)

Amendment No. 2 to the Amended and Restated At Market Issuance Sales Agreement, dated May 2, 2024 by and between Theriva Bilogics, Inc. and and A.G.P./Alliance Global Partners (Filed With SEC on May 2, 2024)

Description of Securities of Theriva Biologics, Inc (Filed With SEC on March 25, 2024)

Lease dated April 14, 2015 between Registrant. and MCC3, LLC (Filed With SEC on March 25, 2024)

Second Amendment to Lease dated May 6, 2021 by and between Registrant and ARE-Maryland No. 50, LLC (Filed With SEC on March 25, 2024)

Employment Agreement with Mary Ann Shallcross dated April 8, 2022 (Filed With SEC on March 25, 2024)

Separation Agreement dated as of May 8, 2023 between Theriva Biologics, Inc. and Frank Tufaro (Filed With SEC on May 11, 2023)

Consulting Agreement dated as of May 8, 2023 between Theriva Biologics, Inc. and Frank Tufaro (Filed With SEC on May 11, 2023)

Description of Securities of Theriva Biologics, Inc (Filed With SEC on March 30, 2023)

Form of Share Repurchase Agreement between Theriva Biologics, Inc. and certain selling stockholders (Filed With SEC on December 23, 2022)

Amendment No. 1 to Employment Agreement between Theriva Biologics, Inc. and Steven A. Shallcross, dated as of December 15, 2022 (Filed With SEC on December 20, 2022)

Amendment No. 1 to Employment Agreement between Theriva Biologics, Inc. and Francis Tufaro, dated as of December 15, 2022 (Filed With SEC on December 20, 2022)

Amendment No. 1 dated as of August 9, 2022 to Securities Purchase Agreement between Synthetic Biologics Inc. and MSD Credit Opportunity Master Fund, L.P., dated as of July 28, 2022 (Filed With SEC on August 11, 2022)

Securities Purchase Agreement between Synthetic Biologics Inc. and MSD Credit Opportunity Master Fund, L.P., dated as of July 28, 2022 (Filed With SEC on July 29, 2022)

Employment Agreement, dated March 22, 2022, between Synthetic Biologics and Frank Tufaro (Filed With SEC on March 23, 2022)

Description of Securities of Synthetic Biologics, Inc (Filed With SEC on March 16, 2022)

Asset Purchase Agreement dated November 8, 2012 between Synthetic Biologics, Inc. and Prev ABR LLC (Filed With SEC on March 16, 2022)

Contract to Grant Marketing License for Catalan Institute of Oncology Patent Ownership Application to VCN Biosciences S.L (Filed With SEC on March 16, 2022)

License Agreement between Bellvitge Biomedical Research Institute Foundation (Idibell) and VCN Biosciences S.L. dated May 4, 2016 (Filed With SEC on March 16, 2022)

Technology Transfer Agreement between Bellvitge Biomedical Research Institute and VCN Biosciences S.L. dated August 31, 2010 (Filed With SEC on March 16, 2022)

Collaboration Agreement to Conduct a Clinical Trial and Grant Operating License Agreement between Hospital Sant Joan Dee Deu and VCN Biosciences, S.L dated February 15, 2016 (Filed With SEC on March 16, 2022)

Amendment, dated March 9, 2022, to the Share Purchase Agreement, by and among Synthetic Biologics, Inc., VCN Biosciences, S.L. and the shareholders of VCN Biosciences, S.L., dated... (Filed With SEC on March 11, 2022)

Employment Agreement with Steven Shallcross dated January 3, 2022 (Filed With SEC on January 4, 2022)

Share Purchase Agreement, by and among Synthetic Biologics, Inc., VCN Biosciences, S.L. and the shareholders of VCN Biosciences, S.L., dated December 14, 2021 (Filed With SEC on December 14, 2021)

Amendment No. 1, dated May 3, 2021, to the Amended and Restated At Market Issuance Sales Agreement by and among Synthetic Biologics, Inc., B. Riley Securities, Inc. and... (Filed With SEC on May 3, 2021)

DESCRIPTION OF SECURITIES REGISTERED PURSUANT TO SECTION 12OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED (Filed With SEC on March 4, 2021)

Amended and Restated At Market Issuance Sales Agreement by and among Synthetic Biologics, Inc., B. Riley Securities, Inc. and A.G.P./Alliance Global Partners, dated February 9,... (Filed With SEC on February 10, 2021)

Termination of Exclusive License Agreement, effective November 9, 2020, by and among Cedars- Sinai Medical Center, Synthetic Biologics, Inc. and Synthetic Biomics, Inc (Filed With SEC on November 10, 2020)

Description of Securities (Filed With SEC on February 20, 2020)

Amendment to Employment Agreement with Steven A. Shallcross dated December 5, 2019 (Filed With SEC on December 5, 2019)

Clinical Trial Agreement between Washington University School of Medicine in St. Louis and Synthetic Biologics, Inc. dated August 7, 2019 (Filed With SEC on August 8, 2019)

Employment Agreement with Steven A. Shallcross dated December 6, 2018 (Filed With SEC on December 6, 2018)

Underwriting Agreement, dated October 10, 2018, by and between Synthetic Biologics, Inc. and A.G.P./Alliance Global Partners, as representative of the underwriters (Filed With SEC on October 15, 2018)

Warrant Agency Agreement, dated October 15, 2018, by and between Synthetic Biologics, Inc. and Corporate Stock Transfer, Inc. (including the form of warrant certificate) (Filed With SEC on October 15, 2018)

Form of Underwriting Agreement (Filed With SEC on October 10, 2018)

Form Warrant Agency Agreement and Form of Warrant Certificate (Filed With SEC on October 10, 2018)

Form of Underwriting Agreement (Filed With SEC on October 10, 2018)

Form Warrant Agency Agreement and Form of Warrant Certificate (Filed With SEC on October 10, 2018)

Form of Underwriting Agreement (Filed With SEC on October 2, 2018)

Form Warrant Agency Agreement and Form of Warrant Certificate (Filed With SEC on October 2, 2018)

Stock Purchase Agreement between Synthetic Biologics, Inc., and Cedars-Sinai Medical Center dated September 5, 2018 (Filed With SEC on September 6, 2018)

Warrant Agreement by and between Synthetic Biologics, Inc. and In-Site Communications (Filed With SEC on May 8, 2018)

Amendment No. 1 to At-The-Market Issuance Sales Agreement dated May 7, 2018 between Synthetic Biologics, Inc. and B. Riley FBR, Inc (Filed With SEC on May 7, 2018)

Fourth Amendment to Exclusive License Agreement entered into February 16, 2017 between Synthetic Biologics, Inc. and Cedars-Sinai Medical Center (Filed With SEC on February 22, 2018)

Fifth Amendment dated August 22, 2017 to Sponsored Research Agreement dated December 19, 2012 between Synthetic Biologics, Inc. and The University of Texas at Austin (Filed With SEC on February 22, 2018)

Amendment to Employment Agreement, dated as of December 20, 2017, by and between Steven A. Shallcross and Synthetic Biologics, Inc (Filed With SEC on December 21, 2017)

Separation Agreement by and between Synthetic Biologics, Inc. and Jeffrey Riley, dated as of December 5, 2017 (Filed With SEC on December 7, 2017)

Registration Rights Agreement, dated September 11, 2017, by and between Synthetic Biologics, Inc. and the holders of the Series A Convertible Preferred Stock (Filed With SEC on September 12, 2017)

Share Purchase Agreement, dated September 11, 2017, by and between Synthetic Biologics, Inc. and the Purchasers named therein (Filed With SEC on September 12, 2017)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on June 2, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on March 2, 2017)

EMPLOYMENT AGREEMENT (Filed With SEC on January 19, 2017)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 2, 2016)

SYNTHETIC BIOLOGICS, INC. 25,000,000 Shares of Common Stock Series A Warrants to Purchase 25,000,000Shares of Common Stock Series B Warrants to Purchase 25,000,000Shares of Common... (Filed With SEC on November 15, 2016)

Exhibit A (Filed With SEC on November 15, 2016)

Exhibit B (Filed With SEC on November 15, 2016)

WARRANT AGREEMENT (Filed With SEC on November 15, 2016)

SYNTHETIC BIOLOGICS, INC. Shares of Common Stock (par value $0.001 per share) At Market Issuance Sales Agreement (Filed With SEC on August 5, 2016)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 10, 2015)

FORM OF STOCKOPTION GRANT NOTICE (Filed With SEC on December 10, 2015)

THIRD AMENDMENT TO EXCLUSIVE LICENSEAGREEMENT (Filed With SEC on November 5, 2015)

AMENDMENT TO STOCK PURCHASE AGREEMENT (Filed With SEC on September 3, 2015)

ExclusiveChannel Collaboration Agreement (Filed With SEC on August 10, 2015)

STOCK ISSUANCE AGREEMENT (Filed With SEC on August 10, 2015)

SECOND AMENDMENT TO REGISTRATION RIGHTSAGREEMENT (Filed With SEC on August 10, 2015)

SYNTHETICBIOLOGICS, INC. 13,333,333Shares of Common Stock UnderwritingAgreement (Filed With SEC on July 17, 2015)

FIFTH AMENDMENT TO THE LICENSE AGREEMENT UC Control No. 2006-04-0026 (Filed With SEC on July 9, 2015)

SIXTH AMENDMENT TO THE LICENSE AGREEMENT UC Control No. 2006-04-0026 (Filed With SEC on July 9, 2015)

CLINICAL TRIAL AGREEMENT (Filed With SEC on July 9, 2015)

AMENDMENT TO CLINICAL TRIAL AGREEMENT (Filed With SEC on July 9, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on May 4, 2015)

SEVERANCE AGREEMENT (Filed With SEC on May 4, 2015)

EMPLOYMENT AGREEMENT (Filed With SEC on March 19, 2015)

SYNTHETICBIOLOGICS, INC. warrantto purchase common stock (Filed With SEC on October 10, 2014)

SUBSCRIPTION AGREEMENT (Filed With SEC on October 10, 2014)

SYNTHETICBIOLOGICS, INC. 14,059,616Shares of Common Stock Warrantsto Purchase 7,029,808 Shares PlacementAgency Agreement (Filed With SEC on October 10, 2014)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on April 21, 2014)

FIRST AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on March 31, 2014)

UNDERWRITING AGREEMENT between SYNTHETIC BIOLOGICS, INC. and AEGIS CAPITAL CORP., as Representative of the Several Underwriters (Filed With SEC on December 13, 2013)

SYNTHETIC BIOLOGICS, INC. CONTROLLED EQUITY OFFERINGSM AmendmentNo. 1 to SALES AGREEMENT (Filed With SEC on December 13, 2013)

EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on December 10, 2013)

EXCLUSIVE OPTION AGREEMENT (Filed With SEC on December 10, 2013)

STOCK PURCHASE AGREEMENT by and among SYNTHETIC BIOLOGICS,INC., SYNTHETIC BIOMICS,INC. and CEDARS-SINAI MEDICALCENTER, INC. December 5, 2013 (Filed With SEC on December 10, 2013)

STOCKPURCHASE AGREEMENT (Filed With SEC on December 10, 2013)

EXCLUSIVE LICENSE AGREEMENT (Filed With SEC on April 16, 2013)

First Amendment to theLicense Agreement Between The Regents of the University of California and General Fiber, Inc. UC Agreement Control No. 2006-04-0026 (Filed With SEC on April 16, 2013)

Second Amendment to the License AgreementBetween the Regents of the University of California and General Fiber, Inc. License Agreement Control No. 2006-04-0026 EffectiveJanuary 3,... (Filed With SEC on April 16, 2013)

THIRD AMENDMENT TO EXCLUSIVE LICENSEAGREEMENT UC Agreement Control No. 2006-04-0026 (Filed With SEC on April 16, 2013)

FOURTH AMENDMENT TO EXCLUSIVE LICENSEAGREEMENT UC Agreement Control No. 2006-04-0026 (Filed With SEC on April 16, 2013)

PATENT LICENSEAGREEMENT AGT. No.PM1300101 (Filed With SEC on December 21, 2012)

SPONSORED RESEARCH AGREEMENT NO. UTA12-000950 (Filed With SEC on December 21, 2012)

SYNTHETIC BIOLOGICS, INC. WARRANTTO PURCHASE COMMON STOCK (Filed With SEC on December 13, 2012)

AMENDMENT TO EMPLOYMENT AGREEMENT (Filed With SEC on December 13, 2012)

ASSET PURCHASE AGREEMENT (Filed With SEC on November 13, 2012)

STOCK PURCHASE AGREEMENT (Filed With SEC on October 31, 2012)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on October 31, 2012)

JOINDER AGREEMENT (Filed With SEC on October 31, 2012)

SYNTHETIC BIOLOGICS, INC. WARRANTTO PURCHASE COMMON STOCK (Filed With SEC on October 31, 2012)

ExclusiveChannel Collaboration Agreement (Filed With SEC on August 9, 2012)

STOCK ISSUANCE AGREEMENT (Filed With SEC on August 9, 2012)

FIRST AMENDMENT TO REGISTRATION RIGHTSAGREEMENT (Filed With SEC on August 9, 2012)

SYNTHETIC BIOLOGICS, INC. WARRANTTO PURCHASE COMMON STOCK (Filed With SEC on March 30, 2012)

EMPLOYMENT AGREEMENT (Filed With SEC on March 30, 2012)

Financial Advisory Agreement Adeona Pharmaceuticals, Inc. 3930 VarsityDrive Ann Arbor, MI 48108 (Filed With SEC on March 30, 2012)

MEMBERSHIP INTEREST PURCHASE AGREEMENT (Filed With SEC on March 12, 2012)

PLEDGE AND SECURITY AGREEMENT (Filed With SEC on March 12, 2012)

NON-RECOURSE PROMISSORY NOTE (Filed With SEC on March 12, 2012)

EMPLOYMENT AGREEMENT (Filed With SEC on February 7, 2012)

EMPLOYMENT AGREEMENT (Filed With SEC on February 6, 2012)

CONSULTING AGREEMENT (Filed With SEC on February 6, 2012)

ExclusiveChannel Collaboration Agreement (Filed With SEC on February 3, 2012)

Exclusive Channel Collaboration Agreement (Filed With SEC on November 21, 2011)

STOCK PURCHASE AGREEMENT (Filed With SEC on November 21, 2011)

REGISTRATION RIGHTS AGREEMENT (Filed With SEC on November 21, 2011)

This warrant is in exchange for the warrant (CSW73) issued on April 11, 2011 (Filed With SEC on August 15, 2011)

This warrant is in exchange for the warrant (CSW__) issued on February 2, 2011 (Filed With SEC on August 15, 2011)

EXCHANGE AGREEMENT (Filed With SEC on August 15, 2011)

WARRANT EXCHANGE AGREEMENT (Filed With SEC on August 15, 2011)

SECURITIES PURCHASE AGREEMENT (Filed With SEC on April 11, 2011)

ADEONA PHARMACEUTICALS, INC. WARRANT TO PURCHASE COMMON STOCK (Filed With SEC on April 11, 2011)

Very truly yours, Adeona Pharmaceuticals, Inc. By: Name:James S. Kuo, M.D., M.B.A. Title:Chairman and CEO Chardan Capital Markets, LLC By: Name: Title: (Filed With SEC on February 2, 2011)

EXECUTIONVERSION SECURITIESPURCHASE AGREEMENT (Filed With SEC on February 2, 2011)

FORMOF WARRANT ADEONAPHARMACEUTICALS, INC. WarrantTo Purchase Common Stock (Filed With SEC on February 2, 2011)

[Signature Page Follows] (Filed With SEC on July 6, 2010)

WARRANT (Filed With SEC on July 6, 2010)

COMMON STOCK PURCHASE AGREEMENT (Filed With SEC on July 6, 2010)

SUBLICENSE AGREEMENT BETWEEN MEDA AB AND PIPEX THERAPEUTICS, INC. May 6, 2010 (Filed With SEC on May 11, 2010)

Re:License agreement between Pipex Therapeutics, Inc. and Meda AB (Filed With SEC on May 11, 2010)

EMPLOYMENT AGREEMENT (Filed With SEC on February 9, 2010)

SEPARATION AGREEMENT (Filed With SEC on February 9, 2010)

AGREEMENT AND PLAN OF MERGER (Filed With SEC on October 19, 2009)

Consent in Lieu of Special Meeting of the Board of Directors of Adeona Pharmaceuticals, Inc. (Filed With SEC on August 26, 2009)

AMENDMENT (Filed With SEC on July 16, 2009)

SECOND AMENDMENT TO (Filed With SEC on July 16, 2009)

CONSULTING AGREEMENT (Filed With SEC on July 16, 2009)

Escrow Agreement (Filed With SEC on July 16, 2009)

EMPLOYMENTAGREEMENT (Filed With SEC on July 2, 2009)

SECONDAMENDMENT TO LICENSE AGREEMENT (Filed With SEC on June 26, 2009)

Exhibit10.1 LIMITEDLIABILITY COMPANY PURCHASE AGREEMENT (Filed With SEC on June 4, 2009)

Exhibit10.1 STOCKPURCHASE AGREEMENT (Filed With SEC on April 16, 2009)

AGREEMENTBY AND BETWEEN ACCREDITEDVENTURE CAPITAL, LLC AND ADEONAPHARMACEUTICALS, INC. DATEDJANUARY 14, 2009 (Filed With SEC on January 20, 2009)

Departure of directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers (Filed With SEC on January 6, 2009)

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Synthetic Biologics, Inc. Contracts & Agreements