SPRUCE BIOSCIENCES, INC. Contracts & Agreements

Non-Employee Director Compensation Policy, as amended on March 30, 2023 (Filed With SEC on May 15, 2023)

Form of Pre-Funded Warrant to Purchase Common Stock (Filed With SEC on February 9, 2023)

Form of Common Stock Purchase Warrant (Filed With SEC on February 9, 2023)

Securities Purchase Agreement, dated February 8, 2023, by and among Spruce Biosciences, Inc. and the Purchasers (Filed With SEC on February 9, 2023)

Lease Agreement, by and between the Company and 611 Gateway Center LP, dated December 1, 2022 (Filed With SEC on December 2, 2022)

Spruce Biosciences, Inc. 2020 Non-Employee Director Compensation Policy, as amended on April 6, 2022 (Filed With SEC on May 11, 2022)

Second Amendment to Loan and Security Agreement, by and between the Registrant and Silicon Valley Bank, dated May 10, 2022 (Filed With SEC on May 11, 2022)

Amendment to Offer Letter, by and between the Company and Javier Szwarcberg, M.D., MPH, dated April 6, 2022 (Filed With SEC on April 8, 2022)

Open Market Sale AgreementSM, by and between the registrant and Jefferies LLC, dated February 25, 2022 (Filed With SEC on March 14, 2022)

Separation and Release Agreement, dated March 11, 2022, by and between the registrant and Rosh Dias, M.D., M.R.C.P (Filed With SEC on March 14, 2022)

Offer Letter, by and between the registrant and Ralph William Charlton III, M.D., M.A.S., dated March 14, 2022 (Filed With SEC on March 14, 2022)

Offer Letter, by and between the Company and Javier Szwarcberg, M.D., MPH, dated December 29, 2021 (Filed With SEC on January 5, 2022)

Form of Stock Option Grant Notice, Option Agreement and Notice of Exercise for Inducement Grant Outside of the Spruce Biosciences, Inc. 2020 Equity Incentive Plan (Filed With SEC on January 5, 2022)

Separation and Release Agreement, dated November 15, 2021, by and between the Registrant and Richard King (Filed With SEC on November 15, 2021)

Description of Common Stock of the registrant (Filed With SEC on March 22, 2021)

SPRUCE BIOSCIENCES, INC. 2020 EMPLOYEE STOCK PURCHASE PLAN OFFERING DOCUMENT ADOPTED BY THE BOARD OF DIRECTORS: SEPTEMBER 9, 2020 (Filed With SEC on March 22, 2021)

First Amendment to Loan and Security Agreement, by and between the registrant and Silicon Valley Bank dated March 19, 2021 (Filed With SEC on March 22, 2021)

Form of Underwriting Agreement (Filed With SEC on October 5, 2020)

Form of Common Stock Certificate (Filed With SEC on October 5, 2020)

Spruce Biosciences, Inc. 2020 Equity Incentive Plan (Filed With SEC on October 5, 2020)

Spruce Biosciences, Inc. 2020 Employee Stock Purchase Plan (Filed With SEC on October 5, 2020)

Spruce Biosciences, Inc. 2020 Non-Employee Director Compensation Policy (Filed With SEC on October 5, 2020)

Form of Common Stock Certificate (Filed With SEC on September 18, 2020)

Amended and Restated Investors Rights Agreement, by and among the registrant and certain of its stockholders, dated February 19, 2020 (Filed With SEC on September 18, 2020)

Form of Warrant to Purchase Common Stock issued to Silicon Valley Bank, dated September 23, 2019 (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. Amended and Restated 2016 Equity Incentive Plan (Filed With SEC on September 18, 2020)

Forms of Grant Notice, Stock Option Agreement and Notice of Exercise under the Spruce Biosciences, Inc. Amended and Restated 2016 Equity Incentive Plan (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. 2020 Equity Incentive Plan (Filed With SEC on September 18, 2020)

Forms of Grant Notice, Stock Option Agreement and Notice of Exercise under the Spruce Biosciences, Inc. 2020 Equity Incentive Plan (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. 2020 Employee Stock Purchase Plan (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. 2020 Non-Employee Director Compensation Policy (Filed With SEC on September 18, 2020)

Form of Indemnification Agreement by and between the registrant and its directors and executive officers (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. Severance and Change in Control Policy (Filed With SEC on September 18, 2020)

Spruce Biosciences, Inc. Severance and Change in Control Plan (Filed With SEC on September 18, 2020)

Consulting Agreement, by and between the registrant and Richard King, dated May 6, 2019 (Filed With SEC on September 18, 2020)

Employment Agreement, by and between the registrant and Richard King, dated October 1, 2019 (Filed With SEC on September 18, 2020)

Employment Agreement, by and between the registrant and Alexis Howerton, Ph.D., dated May 2, 2016 (Filed With SEC on September 18, 2020)

Separation Agreement, by and between the registrant and Alexis Howerton, Ph.D., dated May 24, 2019 (Filed With SEC on September 18, 2020)

Employment Agreement, by and between the registrant and Michael Huang, M.D., dated May 16, 2017 (Filed With SEC on September 18, 2020)

Separation Agreement, by and between the registrant and Michael Huang, M.D., dated February 26, 2020 (Filed With SEC on September 18, 2020)

Offer Letter, by and between the registrant and Samir Gharib, dated April 8, 2020 (Filed With SEC on September 18, 2020)

Offer Letter, by and between the registrant and Rosh Dias, M.D., M.R.C.P., dated July 28, 2020 (Filed With SEC on September 18, 2020)

Letter Agreement, by and between the registrant and Michael Grey, dated March 24, 2017 (Filed With SEC on September 18, 2020)

Letter Agreement, by and between the registrant and Camilla V. Simpson, dated October 11, 2017 (Filed With SEC on September 18, 2020)

Letter Agreement, by and between the registrant and Daniel Spiegelman, dated August 31, 2020 (Filed With SEC on September 18, 2020)

Office Lease Agreement, by and between the registrant and DC Station Owner, LLC, dated February 13, 2020 (Filed With SEC on September 18, 2020)

License Agreement, by and between the registrant and Eli Lilly and Company, dated May 2, 2016 (Filed With SEC on September 18, 2020)

Loan and Security Agreement, by and between the registrant and Silicon Valley Bank, dated September 23, 2019 (Filed With SEC on September 18, 2020)

Deferral Agreement, by and between the registrant and Silicon Valley Bank, dated April 2, 2020 (Filed With SEC on September 18, 2020)

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SPRUCE BIOSCIENCES, INC. Contracts & Agreements