Exhibit 10.22 At the Annual General Meeting ofshareholders held on September 24, 2008, Shire made this service agreementavailable for review. Dated2 July 2008

SHIRE LIMITED (registered number 99854) a company incorporated in and under the laws of Jersey and having its registered office at 22 Grenville Street, St Helier, Jersey JE4 8PX (the "Company"); and

 MR ANGUS RUSSELL of 22 Grenville Street, St Helier, Jersey JE4 8PX (the "Executive").

The Executive's continuous employment with the Company commenced on 13 December 1999.

The employment of the Executive shall (subject to the provisions of Clause 15) be terminable by either the Company or the Executive giving to the other 12 (twelve) months' notice in writing commencing at any time.

The Company may at its absolute discretion elect at any time to terminate the employment of the Executive with immediate effect by paying to the Executive (less deductions as appropriate) salary in lieu of notice and a sum (which shall be calculated by multiplying the Relevant Amount by the number of months' notice which the Executive was entitled to receive at the date of such termination) in compensation for the immediate loss by the Executive of his other benefits hereunder.

In the event that the Company terminates the employment of the Executive pursuant to Clause 1.3.1 at any time, the Relevant Amount shall be the aggregate of:

an amount, to be decided at the absolute discretion of the Remuneration Committee, which may be up to the target annual bonus under the Executive Annual Incentive Plan (EAIP) to which, had he served his notice, the Executive would have been entitled pursuant to Clause 4 based on 100% achievement of group and personal objectives for the bonus year in which his employment terminates (based on the Executive's salary at the date on which his employment terminates), divided by 12 (twelve); and

On the termination of the Executive's employment under this Clause 1, the Executive's rights to receive shares or exercise rights in relation to (or calculated by reference to) shares under any relevant bonus or incentive scheme will be determined in accordance with the rules of the relevant scheme.

serve the Company to the best of his ability in the capacity of Chief Executive Officer;

faithfully and diligently perform such duties and exercise such powers consistent with them as the Board may from time to time properly assign to or confer upon him in such capacity or otherwise in connection with the business of the Company or any Associated Company;

perform and exercise the said duties and powers on behalf of any Associated Company and act as a director or other officer of any Associated Company;

do all in his power to protect, promote, develop and extend the business interests and reputation of the Group;

at all times and in all respects conform to and comply with the lawful and reasonable directions of the Board;

upon receiving reasonable notice promptly give to the Board (in writing if so requested) all such information, explanations and assistance as it may require in connection with the business and affairs of the Company and any Associated Company for which he is required to perform duties;

unless prevented by sickness, injury or other incapacity or as otherwise agreed by the Board devote the whole of his time, attention and abilities during his hours of work (which shall be normal business hours and such additional hours as may be necessary for the proper performance of his duties) to the business and affairs of the Company and any Associated Company for which he is required to perform duties (save that the Executive may, with the prior written consent of the Board, become a non-executive director of other companies);

work at such place of business of the Company or any Associated Company as the Company may reasonably require for the proper performance and exercise of his duties and powers and the Executive may be required to travel on the business of the Company and any Associated Company for which he is required to perform duties; and

During the continuance of his employment the Executive shall devote his whole time and attention to his duties under this Agreement and shall not directly or indirectly carry on or be engaged, concerned or interested in any other business, trade or occupation otherwise than as a holder directly or through nominees (including for the purposes hereof through any trust whether established by the Executive or otherwise and whether discretionary or otherwise of which the Executive is a beneficiary) of not more than 3% in aggregate of any class of shares, debentures or other securities in issue from time to time of any company (or, if different, amounting to no more than 3% in terms of the economic value of all such shares and securities (whether by way of dividend or upon any return in capital) and/or voting or other rights attaching thereto in respect of any matters) which are for the time being quoted or dealt with on any recognised investment exchange (as defined by section 285(1)(a) of the Financial Services and Markets Act 2000) provided that nothing in this Clause 3.1 shall prevent the Executive from continuing to hold his current portfolio of investments in securities.

During the continuance of his employment the Executive shall in relation to any dealings in securities comply with all laws affecting dealings in the securities of such companies and all regulations of any relevant stock exchanges on which such dealings take place.

shall not directly or indirectly procure, accept or obtain for his own benefit (or for the benefit of any other person) any payment, rebate, discount, commission, vouchers, gift, entertainment or other benefit from any third party in respect of any business transacted or proposed to be transacted (excluding air miles or similar vouchers from other such schemes) (whether or not by him) by or on behalf of the Company or any Associated Company ("Gratuities");

shall immediately disclose and account to the Company for any Gratuities received by him (or by any other person on his behalf or at his instruction).

Subject as stated below the Executive shall be entitled to receive a bonus in accordance with the rules and terms of the Company's EAIP scheme (or such other bonus scheme as the Company may implement from time to time). The amount of any bonus shall be at the discretion of the Remuneration Committee. The target annual bonus under the EAIP shall be a cash target of sixty-five per cent (65%) and a share target of twenty per cent (20%) of the Executive's basic annual salary from time to time paid under Clause 4.1. The maximum annual bonus under the EAIP shall be a cash bonus of one hundred fifteen per cent (115%) and a maximum share bonus of sixty-five per cent (65%) of the Executive's basic annual salary under Clause 4.1. Any bonus payment shall be subject to deductions as appropriate. The Company reserves the right to change any bonus terms from year to year.

In the event that the Executive's employment hereunder terminates during any bonus year he shall be entitled to receive a proportion of the bonus he would have received had his employment not been terminated and the Remuneration Committee shall use its best endeavours but at its sole discretion to determine the estimation of such bonus. Such proportion shall be calculated as the fraction derived from dividing the period during which the Executive was employed hereunder during the relevant bonus year by the period of the bonus year.

The Executive shall be entitled to a pension contribution in respect of his basic salary (but excluding the Irish Board Fee). The Company shall contribute to such pension scheme as the Executive shall specify an amount equal to such proportion of his basic salary (excluding the Irish Board Fee) as would give rise to a contribution equal to thirty per cent (30%) of the Executive's basic salary under clause 4.1.from time to time. Such contributions shall be made monthly at the date when salary is paid Isn't hereunder redundant here?. Such contributions shall be in addition to the Executive's basic salary.

provide for the Executive and his partner or spouse and children under the age of 18 years membership of an appropriate private patient medical plan (to include cover for dental treatment) with such reputable medical expenses insurance scheme as the Company shall decide from time to time. The Executive shall be entitled to remain a member of such plan in accordance with and subject to its rules from time to time. The Executive shall also be allowed to participate in an annual Executive Physical program, subject to a maximum annual reimbursement of £1,500;

provide the Executive with life assurance cover which in the event of his death during the continuance of his employment may pay to his chosen dependants (subject only to the discretion of the trustees of the appropriate scheme) a lump sum equal to a minimum of 4 (four) times his then annual rate of salary. If such lump sum is more than the permitted maximum, such surplus will be made available (subject to the discretion of the trustees aforesaid) for the purchase of an annuity for the Executive's dependants subject as necessary to a medical examination. The Executive will co ­operate with the Company in any way reasonably necessary in order for the Company to comply with its obligations thereunder including, without prejudice to the generality hereof, by submitting himself for such medical examination as may be required of him in connection therewith from time to time;

provide for the Executive membership at the cost of the Company of any permanent health care scheme and prolonged disability scheme operated by the Group for the benefit of executives. The Executive shall be entitled to remain a member of such scheme in accordance with and subject to its rules from time to time; and

provide Directors' and Officers' insurance cover for the benefit of the Executive under the same policy as will be provided for the other directors such cover to continue to cover the Executive in respect of acts or omissions committed during his employment hereunder whether claims are made during or within the period of 7 (seven) years after the termination of the employment hereunder.

The Company shall during the continuance of his employment reimburse the Executive in accordance with the Company's travel and expenses policy as amended from time to time.

The Company shall, under its Executive Financial Services Reimbursement Programme, provide the Executive with the sum of £5,000 per annum (less any deductions the Company is required to make by law) towards the cost of legal expenses and financial planning services.

The Executive shall (in addition to the usual public and bank holidays) be entitled during the continuance of his employment to 30 (thirty) working days' paid holiday in each holiday year, or such greater number in accordance with the Company's policy from time to time to be taken at a time or times as shall be convenient to the Company.

The Executive shall be entitled to carry forward to the following year up to 5 days' untaken annual holiday entitlement in each holiday year. The carry forward of any additional holiday entitlement not taken by him for any reason from one holiday year to the next shall require the prior written consent of the Board (such consent not to be unreasonably withheld).

Upon the termination of his employment the Executive's entitlement to accrued holiday pay (which accrues at the rate of 2.5 days per month) shall be calculated on a pro rata basis in respect of each completed month of service in the holiday year in which his employment terminates and the appropriate amount shall be paid to the Executive in addition to payment in lieu for any holidays not taken in previous holiday years provided that if the Executive shall have taken more days holiday than his accrued entitlement the Company is hereby authorised to make an appropriate deduction from the Executive's final salary payment.

Subject to his complying with the Company's procedures relating to the notification and certification of periods of absence from work as from time to time in force the Executive shall continue to be paid his salary (inclusive of any statutory sick pay or social security benefits to which he may be entitled) during any periods of absence from work due to sickness, injury or other incapacity incapacitating the Executive from attending to his duties up to a maximum of 26 (twenty-six) weeks in aggregate in any period of 52 (fifty-two) consecutive weeks.

If the Executive shall have been absent from work due to sickness, injury or other incapacity for a continuous period of 26 (twenty-six) weeks or more then he shall receive such benefits (if any) as are available to him under the terms of the Company's permanent health insurance scheme or such greater sum (if any) as the Board may in its absolute discretion decide.

If any incapacity of the Executive shall be or appear to be caused by any alleged action or wrong of a third party and the Executive shall decide to claim damages in respect thereof, then the Executive shall use all reasonable endeavours to recover damages for loss of earnings over the period for which salary has been or will be paid to him by the Company under Clause 11.1, and shall account to the Company for any such damages recovered (in an amount not exceeding the actual salary paid or payable to him by the Company under Clause 11.1 in respect of the said period) less any costs borne by him in achieving such recovery.

all rights (including, without limitation, all IPRs) in and to such Works shall solely legally and beneficially vest in the Company immediately upon their creation without any payment to the Executive;

the Executive hereby irrevocably and unconditionally waives, in favour of the Company, its licensees and successors-in-title any and all moral rights conferred on the Executive in relation to the Works (existing or future); and

the Executive shall not knowingly do anything, or omit to do anything, to imperil the validity of any patent or protection, or any application therefore, relating to any of the Works.

All notes and memoranda of any trade secret or confidential information concerning the business of the Company or the Associated Companies or any of its or their suppliers, agents, distributors, customers or others which shall have been acquired, received or made by the Executive during the course of his employment shall be the property of the Company and shall be surrendered by the Executive to someone duly authorised in that behalf at the termination of his employment or at the request of the Board at any time during the course of his employment.

Without prejudice to the generality of Clause 13.1 the following is, for the avoidance of doubt, a non-exhaustive list of matters which in relation to the Company and the Associated Companies are considered confidential and must be treated as such by the Executive (for the purposes of this Agreement):

shall not take away, conceal or destroy but shall immediately deliver up to the Company all documents (which expression shall include but without limitation notes, memoranda, correspondence, drawings, sketches, plans, designs and any other material upon which data or information is recorded or stored) relating to the business or affairs of the Company or any Associated Company or any of their clients/customers, shareholders, employees, officers, suppliers, distributors and agents (and the Executive shall not be entitled to retain any copies or reproductions of any such documents) together with any other property belonging to the Company or any Associated Company (including his car and its keys) which may then be in his possession or under his control;

shall, at the request of the Board and without prejudice to any rights of the Executive arising as a result of the loss of his employment hereunder, immediately resign without claim for compensation from office as a director of the Company and any Associated Company and from any other office held by him in the Company or any Associated Company (but without prejudice to any claim he may have for damages for breach of this Agreement) and in the event of his failure to do so the Company is hereby irrevocably authorised to appoint some person in his name and on his behalf to sign and deliver such resignations to the Board and/or to each such Associated Company;

shall not at any time thereafter make any untrue or misleading oral or written statement concerning the business and affairs of the Company or any Associated Company nor represent himself or permit himself to be held out as being in any way connected with or interested in the business of the Company or any Associated Company (except as a former employee for the purpose of communicating with prospective employers or complying with any applicable statutory requirements);

shall not at any time thereafter use the name "Shire" or any name capable of confusion therewith (whether by using such names as part of a corporate name or otherwise) (save for the making of factual statements (subject always to the provisions of Clause 13) describing his employment with the Company for the purposes of obtaining an alternative remunerated position as defined at Clause 15.4(vii)); and

shall immediately repay all outstanding debts or loans due to the Company or any Associated Company and the Company is hereby authorised to deduct from any wages (as defined by section 27 of the Employment Rights Act 1996) of the Executive a sum equal to any such debts or loans.

If the employment of the Executive under this Agreement is terminated by reason of the liquidation of the Company for the purpose of reconstruction or amalgamation or as part of any arrangement for the amalgamation or reconstruction of the Company not involving insolvency and the Executive is offered employment with any concern or undertaking resulting from the reconstruction or amalgamation on terms and conditions which taken as a whole are not less favourable than the terms of this Agreement then the Executive shall have no claim against the Company in respect of such termination.

Notwithstanding the provisions of Clauses 1.2, 1.3 and 15.1 of this Agreement, the Company may instead, at its sole discretion, terminate the Executive's employment by giving written notice to him that it is exercising its rights under this Clause 15.4 to terminate the employment and make Monthly Payments (as defined below) to the

On the termination of the Executive's employment under this Clause 15, the Executive's rights to receive shares or exercise rights in relation to (or calculated by reference to) shares under any relevant bonus or incentive scheme will be determined in accordance with the rules of the relevant scheme.

The Executive shall be under a duty, beginning on the Commencement Date, to use reasonable endeavours actively to seek a suitable alternative remunerated position (defined below) and shall also be required to keep the Company informed in relation to his search when reasonably requested.

each of the Monthly Payments still outstanding shall be reduced by the basic monthly remuneration to which the Executive is entitled, from the alternative remunerated position, and only the balance shall be due to the Executive;

any benefits provided by the Company (or their value paid in lieu as part of the Monthly Payments) which are provided by the alternative remunerated position (on an equivalent basis) shall cease;

for the purposes of calculating the amount of the deduction in respect of remuneration from the alternative remunerated position, any basic salary or fees shall be included, together with the value of any pension provided, but not any entitlement to bonus or the value of any equity or equity-based incentive arrangements. The value of any entitlement to pension shall be calculated as the amount which the new employer contributes to a pension scheme on the Executive's behalf (in the case of a defined benefit arrangement, being the long term contribution rate, ignoring any adjustment to reflect an overall deficit or surplus in the scheme).

The Executive will not be entitled to receive any payment in addition to the Monthly Payments in respect of any holiday entitlement that would have accrued during the period for which the Monthly Payments are made, and will not accrue any entitlement to pension contributions or bonus during such period.

The Executive acknowledges that during the course of his employment with the Company he will receive and have access to confidential information of the Company and its Associated Companies (including without limitation those matters specified in Clause 13.3 of this Agreement) and he will also receive and have access to detailed client/customer lists and information relating to the operations and business requirements of those clients/customers and accordingly he is willing to enter into the covenants described in this Clause 16 in order to provide the Company and its Associated Companies with what he considers to be reasonable protection for those interests.

"Restricted Business" means the Business of the Company and its Associated Companies at the time of the termination of the Executive's employment with which the Executive was involved to a material extent at any time during the period of 12 (twelve) months ending on the Restriction Date and for the purposes of this Clause the term "Business" shall mean the research, development, marketing, sale or supply of pharmaceuticals for administration to humans;

"Restricted Customer" means any firm, company or other person who, at any time during the period of 12 (twelve) months ending on the Restriction Date, was a customer of or in the habit of dealing with the Company or any Associated Company and with whom the Executive dealt to a material extent or for whom or which the Executive was responsible on behalf of the Company or any Associated Company during that period and in respect of such customer material damage to the interests of the Company or any Associated Company could occur if such customer ceased or reduced its business with the Company or any Associated Company;

"Restricted Employee" means any person who, at the Restriction Date was employed by the Company or any Associated Company at a senior level and who could materially damage the interests of the Company or any Associated Company if he became employed in any business concern in competition with the Restricted Business and with whom the Executive worked closely or about whom the Executive obtained material detailed information, in either case at any time during the period of 12 (twelve) months ending on the Restriction Date; and

The Executive will not, for a period of 12 (twelve) months after the Restriction Date, solicit or endeavour to entice away from the Company or any Associated Company the business or custom of a Restricted Customer with a view to providing or receiving goods or services to or from that Restricted Customer in competition with any Restricted Business.

The obligations imposed on the Executive by this Clause 16 extend to him acting not only on his own account but also on behalf of any other firm, company or other person and shall apply whether he acts directly or indirectly.

The Executive hereby agrees that he will at the request and expense of the Company enter into a direct agreement or undertaking with any Associated Company whereby he will accept restrictions and provisions corresponding to the restrictions and provisions in this Clause 16 (or such of them as may be appropriate in the circumstances) in relation to such activities and such area and for such a period not exceeding 12 (twelve) months as such Associated Company may reasonably require for the protection of its legitimate business interests.

Subject to Clause 17.6 below "Change of Control" means where any person either alone or together with any person acting in concert with him obtains control of the Company as defined in section 840 of the Income and Corporation Taxes Act 1988.

an amount in lieu of annual bonus to be decided at the absolute discretion of the Remuneration Committee, as that committee was constituted immediately prior to the Change of Control, up to the maximum bonus, based on 150% achievement of group and personal objectives for the bonus year in which his employment terminates (based on the Executive's salary at the date on which his employment terminates); and

an amount in lieu of the Company's contributions to the Executive's pension scheme under Clause 6 of this Agreement for 1 (one) year; and

an amount in respect of the actual cost to the Company of the provision of the benefits due under Clauses 7 and 8 of this Agreement for 1 (one) year.

Subject to any rights accrued at the date of termination of the Executive's employment under the provisions of any pension scheme of the Company, any payment by the Company pursuant to this Clause 17 shall be made in full and final settlement of all and any claims arising from or in connection with the Executive's employment or its termination or his office as Chief Executive Officer and its loss in each case in respect of the Company or any Associated Companies.

The Executive hereby agrees that he shall not, following a payment under this Clause 17, bring any claim before any court or employment tribunal relating to unfair dismissal.

This Clause shall not apply where in connection with a scheme of reconstruction or amalgamation or reorganisation of the Company and one or more of its Associated Companies the Executive refuses an offer of employment on terms identical in all material respects to those hereunder by the company which following such reconstruction or reorganisation replaces the Company or the relevant Associated Companies.

During the continuance of his employment the Executive may be required to work in the USA or such other jurisdiction as the Company may request from time to time (the "Foreign Jurisdiction").

The Company shall ensure that the Executive is covered by a tax equalisation programme so that, if for any reason the Executive is subject to tax (as a direct result of business duties) in the Foreign Jurisdiction in respect of his remuneration under this Agreement which is not creditable in the UK, then a reconciliation will be undertaken to ensure that, so far as

Following the reconciliation exercise in accordance with Clause 18.2 the Executive shall repay to the Company any excess income benefits or the Company shall make any additional tax equalisation payments due to the Executive in the form of allowances as necessary. If appropriate, such payments shall be enhanced to allow for any further tax which may be due on them.

The Executive shall be required to consult PricewaterhouseCoopers or such other firm of professional advisers as the Company may request from time to time about his tax position in the Foreign Jurisdiction and the Company will bear the reasonable costs of such consultancy services as well as the cost of annual tax return preparation services in the UK and the Foreign Jurisdiction.

The Executive shall be expected to maintain the highest standard of integrity and behaviour. For the purpose of disciplinary and grievance procedures the Executive's supervisor is the Board.

If the Executive is not satisfied with any disciplinary decision taken in relation to him he may apply in writing within 14 (fourteen) days of that decision to the Board whose decision shall be final.

The Executive hereby warrants that by virtue of entering into this Agreement he will not be in breach of any express or implied terms of any contract or of any other obligations legally binding upon him.

Any benefits provided by the Company to the Executive or his family which are not expressly referred to In this Agreement shall be regarded as ex gratia benefits provided at the entire discretion of the Company and shall not form part of the Executive's contract of employment.

The Company shall be entitled at any time during the Executive's employment to make deductions from the Executive's salary or from any other sums due to the Executive from the Company or any Associated Company in respect of any overpayment of any kind made to the Executive or in respect of any debt or other sum due from him provided always that reasonable evidence of the validity of such deductions is provided to the Executive.

Any reference in this Agreement to the employment of the Executive is a reference to his employment by the Company whether or not during the currency of this Agreement.

Any word in this Agreement which denotes the singular shall where the context permits include the plural and vice versa and any word in this Agreement which denotes the masculine gender shall where the context permits include the feminine and/or the neuter genders and vice versa.

Any reference in this Agreement to a statutory provision shall be deemed to include a reference to any statutory amendment, modification or re-enactment of it.

This Agreement supersedes all previous agreements between the parties or any Associated Company relating to the employment of the Executive.