Amendment to Employment Agreement by and between the Registrant and Benjamin Jackson, dated May 20, 2021

This letter is an amendment (the “Amendment No.1”) to the Employment Agreement between you and Sera Prognostics, Inc. dated April 13, 2021 (the “Employment Agreement”) for the purpose of amending your bonus percentage. The following sentence in Section 2(b) (“Stock Option Grant(s) and Bonuses”):

You will be eligible to participate in the Company’s Annual Incentive Plan, which currently provides for a bonus target of 30% of your base salary, prorated for time of service, and with respect to the calendar year ending December 31, 2021, payment will be contingent based on achievements mutually agreed by you and your supervisor.

shall be deleted and replaced with the following sentence:

You will be eligible to participate in the Company’s Annual Incentive Plan, which currently provides for a bonus target of 35% of your base salary, prorated for time of service, and with respect to the calendar year ending December 31, 2021, payment will be contingent based on achievements mutually agreed by you and your supervisor.

All other terms, conditions and provisions of the Employment Agreement, including but not limited to all other provisions of Section 2(b), shall remain unchanged by this amendment and are in full force and effect. This Amendment No.1 shall be effective upon execution by both parties below.

                            Sincerely,

                            Sera Prognostics, Inc.

This Amendment is accepted and agreed to as of the date hereof: