Amendment No. 18 to Cooperation Agreement between Tufts University and Genzyme Transgenics Corporation

Summary

This amendment extends the existing cooperation agreement between Tufts University’s School of Veterinary Medicine and Genzyme Transgenics Corporation for three additional years, through September 5, 2004. It updates the project budget for the maintenance of goat herds, with specific costs outlined for each year. All other terms of the original agreement remain unchanged. The amendment is effective as of September 6, 2001.

EX-10.6-9 5 a2106144zex-10_69.txt EXHIBIT 10.6.9 CONFIDENTIAL Exhibit 10.6.9 CONFIDENTIAL TREATMENT GTC Biotherapeutics, Inc. has requested that the marked portions of this document be accorded confidential treatment pursuant to Rule 24b-2 promulgated under the Securities Exchange Act AMENDMENT NO. 18 to COOPERATION AGREEMENT This Amendment No. 18, effective September 6, 2001 to the Cooperation Agreement dated September 6, 1988, as subsequently amended (the "Amended Agreement") by and between Tufts University acting through its School of Veterinary Medicine ("TUSVM") and Genzyme Transgenics Corporation ("GTC"). GTC and TUSVM hereby further amend the Amended Agreement as follows: 1. The Further Extended Term is extended to September 5, 2004 ("Years 9, 10 and 11). 2. The Budget for Years 9, 10 and 11 of the Further Extended Term is attached hereto as Exhibit I. To the extent not inconsistent herewith, all of the remaining terms of the Amended Agreement shall continue in full force and effect. TUFTS UNIVERSITY GENZYME TRANSGENICS CORPORATION By: /s/ Gerald C. Wodehouse By: /s/ Carol A. Ziomek, Ph.d. -------------------------------- --------------------------- Gerald C. Wodehouse Carol A. Ziomek, Ph.D. Associate Director Vice President, Development Grants and Contracts Administration CONFIDENTIAL TUFTS/GENZYME TRANSGENICS CORP. Cooperative Services Agreement Goat Herd Maintenance Project Year 9: September 8, 2001 - September 5, 2002 EXHIBIT I TO AMENDMENT 18: ESTIMATED BUDGET FOR HOUSING IN GOAT BARNS I AND II

- ---------- (*) Confidential Treatment has been requested for the marked portion.