AMENDMENT #2 TO MANUFACTURING AGREEMENT

EX-10.4.2 4 y06183exv10w4w2.txt AMENDMENT #2 TO MANUFACTURING AGREEMENT Exhibit 10.4.2 [Merck & Co., Inc. Letterhead] October 24, 1996 Mr. Murray Goldberg Regeneron Pharmaceutical, Inc. 777 Old Saw Mill River road Tarrytown, NY 10591 Dear Mr. Goldberg: This shall serve as a memorandum of our agreement to amend Schedule A of the Manufacturing Agreement between Merck & Co., Inc. ("Merck") and Regeneron Pharmaceuticals, Inc. (Regeneron") dated September 18, 1995, so as to permit Merck to use Room [***], as depicted on the diagram annexed to Schedule A of the Manufacturing Agreement, in conjunction with Regeneron, for [***] purposes in support of the manufacture of Product pursuant to said agreement. Room [***] is indicated in red outline on the diagram attached hereto. Regeneron shall designate said area as a "[***] area" on the diagram attached to Schedule A of the Agreement. In consideration for the [***] use of Room [***] for the term of the Agreement, Merck, within 60 days of the execution of this letter agreement by Regeneron , shall remit to Regeneron a one-time payment of [***]. If the foregoing is agreeable, would you please so indicate by signing, dating and returning to us the enclosed copy of this letter. Very truly yours, Merck & Co., Inc. /s/John M. Pashko ------------------------------- John M. Pashko Date: 11/25/96 The foregoing is agreed to: Regeneron Pharmaceuticals, Inc. /s/Murray Goldberg - ------------------ Murray Goldberg Date: 11/06/96