CLINICAL TRIAL SERVICES AGREEMENT AMENDMENT NO. 8 TO WORK STATEMENT NB-1

NOW THEREFORE, in consideration of the mutual covenants and promises contained in this Amendment No. 8, the parties agree as follows:

1. End of Study Readiness Visits for BA058-05-003:

(a) At Radius request, NB will allocate resources as outlined below to perform additional activities to assist selected study sites for the end of the BA058-05-003 Study in order to meet consistency in documentation across the sites. The purpose of this work statement is to allow NB the resources to visit selected sites and vendors to perform end of study readiness visits. Radius is responsible for selecting the sites targeted for these visits.

(b) A new section at the bottom Attachment B to Work Statement NB-1 (Budgets, Fees, Pass-through Costs, and Payment Schedule) is hereby amended to read in full as follows:

(c) The “Payment Schedule” set forth in Attachment B to Work Statement NB-1 (Attachment 2 to the Agreement) is amended to add a new Paragraph (16)  immediately following Paragraph (15) of the Payment Schedule, which shall read in full as follows:

“Payment for End of Study Readiness Visits will be paid in 4 parts; 40% upon signing of this work statement, 30% after data base transfer in October, 2014, 15% when the database is soft locked and transferred to Radius in November 2014, and 15% when the data base is hard locked and transferred to Radius in December, 2014. Such payments shall include all out-of-pocket travel expenses incurred by NB for study readiness visits”

2.  Ratification.  Except to the extent expressly amended by this Amendment No. 8, all of the terms, provisions and conditions of the Agreement and Work Statement NB-1 are hereby ratified and confirmed and shall remain in full force and effect.  The term “Work Statement NB-1”, as used in the Agreement, shall henceforth be deemed to be a reference to Work Statement NB-1 as amended by this Amendment No. 8.

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