Third Amendment, dated May 23, 2018, to Lease, dated May 14, 2014, between the Company and BP Bay Colony LLC

THIRD AMENDMENT TO LEASE dated as of this 23^rd day of May, 2018 (the “Third Amendment Effective Date”) by and between BP BAY COLONY LLC, a Delaware limited liability company (“Landlord”), and RADIUS HEALTH, INC., a Delaware corporation (“Tenant”).

By Lease dated May 14, 2014 (the “Lease”), Landlord did lease to Tenant, and Tenant did hire and lease from Landlord, certain premises containing approximately 8,490 square feet of rentable floor area located on the first (1^st) floor (referred to in the First Amendment (hereinafter defined) as the “Initial Premises”) of the building known and numbered as 950 Winter Street, Waltham, Massachusetts (the “Building”).

By First Amendment to Lease dated as of September 9, 2015 (the “First Amendment”), Tenant (i) leased from Landlord an additional 8,176 square feet of rentable floor area located on the first (1^st) floor of the Building, which space is shown on Exhibit A attached to such First Amendment (referred to in the First Amendment as the “Expansion Premises 1”), (ii) leased from Landlord an additional 10,542 square feet of rentable floor area (referred to in the First Amendment as the “Rentable Floor Area of the Expansion Premises 2”) located on the first (1^st) floor of the Building, which space is shown on Exhibit B attached to such First Amendment (referred to in the First Amendment as the “Expansion Premises 2”), and (iii) extended the Term of the Lease, upon all of the same terms and conditions set forth in the Lease except as set forth in the First Amendment.

By Second Amendment to Lease dated as of April 22, 2016 (the “Second Amendment”), Landlord and Tenant agreed to increase the size of Expansion Premises 1 by 432 square feet of rentable floor area, upon all of the same terms and conditions set forth in the Lease except as set forth in the Second Amendment.

Landlord and Tenant have agreed that the Expansion Premises 2 contains 9,455 square feet of rentable floor area, which is 1,087 square feet (the “Expansion Premises 2 Square Footage Delta”) less than the 10,542 square feet of rentable floor area that is set forth as the “Rentable Floor Area of the Expansion Premises 2” in the First Amendment, and the parties are entering into this Third Amendment to Lease (this “Third Amendment”) to set forth said agreement and to otherwise amend the Lease as set forth herein.

Effective as of June 1, 2018, the “Rentable Floor Area of the Expansion Premises 2” shall be 9,455 square feet of rentable floor area and the “Rentable Floor Area of the Premises” shall be 26,553 square feet of rentable floor area. For the avoidance of doubt, the parties acknowledge and agree that Exhibit B attached to the First Amendment accurately depicts the Expansion Premises 2 containing 9,455 square feet of rentable floor area.

“(C)    Commencing on June 1, 2018, Annual Fixed Rent with respect to Expansion Premises 2 shall be payable as follows:

(B)Within sixty (60) days following the Third Amendment Effective Date, Landlord shall make a one-time lump sum payment to Tenant in the amount of Sixty-Three Thousand Two Hundred Forty-Two and 00/100 Dollars ($63,242.00), which shall constitute reimbursement in full for the Annual Fixed Rent attributable to the Expansion Premises 2 Square Footage Delta paid by Tenant to Landlord for the period from the Expansion Premises 2 Commencement Date through May 31, 2018.

3.Parking. The parties acknowledge and agree that the Number of Parking Spaces is currently eighty-two (82), and they further acknowledge and agree that, notwithstanding anything in the Lease or this Third Amendment to the contrary, the Number of Parking Spaces shall not be impacted by this Third Amendment.

4.    Defined Terms. Except as otherwise expressly provided herein, all capitalized terms used herein without definition shall have the same meanings as are set forth in the Lease.

5.    Ratification of Lease. Except as herein amended, the Lease shall remain unchanged and in full force and effect. All references to the “Lease” shall be deemed to be references to the Lease, as previously amended by the First Amendment and the Second Amendment and as amended by this Third Amendment.

6.    Authority. Each of Landlord and Tenant hereby represents and warrants to the other that all necessary action has been taken to enter this Third Amendment and that the person signing this Third Amendment on its behalf has been duly authorized to do so.

7.    Counterparts. This Third Amendment may be executed in counterparts, and such counterparts together shall constitute but one original of the Third Amendment. Each counterpart shall be equally admissible in evidence, and each original shall fully bind each party who has executed it. Provided it is accompanied by the final version of this Third Amendment (including all exhibits, if any), an executed signature page of this Third Amendment delivered by facsimile or as a PDF or a similar attachment to an email shall constitute effective delivery of this Third Amendment by the party so delivering the same for all purposes with the same force and effect as the delivery of an executed original counterpart.

EXECUTED as of the date and year first above written.