Offer dated September 4, 2019 to vary the missives between Quotient Biocampus Limited (Quotient) and Roslin Assets Limited (Roslin) in respect of the purchase by Roslin from Quotient of the heritable property known as Site 3, Bio Campus, Roslin, Midlothian

Exhibit 10.1

DWF LLP

110 Queen Street Glasgow G1 3HD OX GW9 LP- 1 Glasgow 12 T +44 (0 ###-###-#### F +44 (0 ###-###-#### www.dwf .law

Dear Sirs

We refer to the Missives between our client, QUOTIENT BIOCAMPUS LIMITED, incorporated under the Companies Acts (Registered Number SC514165) and having its Registered Office formerly at Douglas Buildings, Pentlands Science Park, Bush Loan, Penicuik, EH26 OPL and now at 5 JAMES HAMILTON WAY MILTON BRIDGE PENICUIK EH26 OBF ("Quotient") and your client ROSLIN ASSETS LIMITED, incorporated under the Companies Acts (Registered Number 10893348 ) and having its Registered Office formerly at 5th Floor, Maybrook House, 40 Blackfriars Street, Manchester M3 2EG and now at 1st Floor Rico House, George Street, Prestwich, Manchester, Lancashire, M25 9WS ("Roslin") in respect of the purchase by Roslin from Quotient of the heritable property known as Site 3, Bio Campus,  Roslin, Midlothian extending to 3.18 hectares , comprising our offer on behalf of Quotient dated 16 February 2018 ("the Offer") and your concluding letter on behalf of Roslin dated 19 February 2018 (together "the Missives") .

In terms of clauses 2.8 and 18 and Part 18 of the Schedule to the Offer, Quotient and Roslin agreed that the Price Retention (as defined in the Offer) was to be held in an interest bearing account as stakeholders for Quotient and Roslin pending the occurrence of the Payment Date (as defined in the Offer).

On behalf of and as instructed by Quotient we hereby offer to vary the Missives as follows:

67006704-1

DWF LLP is a limited liability partnership registered in England and Wales wit h registered number OC328794 DWF LLP is recogn1sed as both an Incorporated Practice and a Multi National Practice by The Law Society of Scotland (registered number 43186) The term 'Partner' is used to refer to a Member of DWF LLP or an employee or consultant with equivalent standing and qualifications

A list of Members of OWF LLP and of Non-Members who are designated as Partners r s open to inspection at its registered office located at

1 Scolt Place, 2 Hardman Street Manchester , M3 3AA

DWF LLP r s listed on the Financial Services Register as an Exempt Professional Firm, able to carry out certain insurance mediation activities

(regulated by the Law Society of Scotland)

DWF LLP- Edinburgh

4 September 2019

Election annexed to this letter Quotient shall have no further liability to Roslin in terms of Clauses 1.3,

1.4 and 1.11 of Part 18 of the Schedule to the Offer.

67006704-1