Amendment to Employment Agreement, dated as of October 15, 2021, by and between Quotient Limited and Manuel O. Mndez

Exhibit 10.3

Attention Manuel O. Méndez, Chief Executive Officer

October 15, 2021

Dear Manuel:

Reference is made to that certain Employment Agreement between you and Quotient Limited (the “Company”), dated as of February 23, 2021 and amended June 7 and October 5, 2021(the “Employment Agreement”).

The “Sign-On Equity Grant” provided by your Employment Agreement in Sections 5(a) and 5(b) of Schedule 1 will be reduced by respectively 181.159 Company restricted stock units and 138.227 Company stock options which will be cancelled in due proportion of the respective vesting calendars.

in lieu thereof the Company shall promptly pay to you in cash in U.S. Dollars 1,000,000 net of social security and tax cost deductions, to further support your relocation to Switzerland.

Please indicate your agreement to the foregoing by executing this letter in the space provided below and emailing it to me.

Sincerely,