Prothena Corp plc Contracts & Agreements

Fifth Amendment to the Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 17, 2024)

Offer letter, dated February 12, 2024, between Prothena Biosciences Inc and David A. Ford (Filed With SEC on May 8, 2024)

Side Letters to Master Collaboration Agreement, dated as of March 20, 2018, between Prothena Biosciences Limited and Celgene Switzerland LLC (Filed With SEC on May 8, 2024)

Description of Registrants Securities (Filed With SEC on February 22, 2024)

First through (Filed With SEC on February 22, 2024)

Consulting Agreement (Filed With SEC on November 2, 2023)

Global License Agreement, dated as of July 5, 2023, by and between Prothena Biosciences Limited and Celgene Switzerland LLC (Filed With SEC on November 2, 2023)

Fourth Amendment to the Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 19, 2023)

Fourteenth Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on May 4, 2023)

Description of Registrants Securities (Filed With SEC on February 28, 2023)

Sublease, dated as of October 28, 2022, by and between Arcus Biosciences, Inc. and Prothena Biosciences Inc (Filed With SEC on February 28, 2023)

Consent to Sublease Agreement, dated as of October 28, 2022, by and among HCP LS Brisbane, LLC, Arcus Biosciences, Inc., and Prothena Biosciences Inc (Filed With SEC on February 28, 2023)

First through Thirteenth Amendments to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on February 28, 2023)

Underwriting Agreement dated December 14, 2022 by and among Prothena Corporation plc and the Representatives (Filed With SEC on December 16, 2022)

Consulting Agreement, dated October 1, 2022, between Prothena Biosciences Inc and Dennis J. Selkoe (Filed With SEC on November 3, 2022)

Third Amendment to the Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 20, 2022)

Description of Registrants Securities (Filed With SEC on February 25, 2022)

First through Eleventh Amendments to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on February 25, 2022)

Distribution Agreement, dated December 23 2021, by and among the Company, Piper Sandler & Co., Stifel, Nicolaus & Company, Incorporated, Cantor Fitzgerald & Co., RBC Capital... (Filed With SEC on December 23, 2021)

Tenth Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on November 4, 2021)

Amended and Restated Consulting Agreement, dated July 15, 2020, between Prothena Biosciences Inc and Dennis J. Selkoe (Filed With SEC on November 4, 2021)

Amendment No. 2 to License, Development, and Commercialization Agreement, entered into on December 11, 2013, among Prothena Biosciences Limited, Prothena Biosciences Inc, F.... (Filed With SEC on November 4, 2021)

Share Purchase Agreement, dated as of July 8, 2021, by and among Novo Nordisk A/S, Novo Nordisk Region Europe A/S, Prothena Corporation plc, and Prothena Biosciences Limited (Filed With SEC on November 4, 2021)

U.S. License Agreement, dated as of July 30, 2021, as amended on August 12, 2021 and September 8, 2021, by and between Prothena Biosciences Limited and Celgene Switzerland LLC (Filed With SEC on November 4, 2021)

Eighth Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on August 5, 2021)

Ninth Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on August 5, 2021)

Distribution Agreement, dated May 28, 2021, by and among the Company, Piper Sandler & Co., Stifel, Nicolaus & Company, Incorporated, Cantor Fitzgerald & Co., RBC Capital Markets,... (Filed With SEC on May 28, 2021)

Second Amendment to the Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 21, 2021)

Offer Letter, dated March 18, 2021, between Prothena Biosciences Inc and Hideki Garren (Filed With SEC on May 11, 2021)

Seventh Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on May 11, 2021)

Underwriting Agreement, dated March 23, 2021, by and among Prothena Corporation plc and Citigroup Global Markets Inc., Jefferies LLC, and Cantor Fitzgerald & Co (Filed With SEC on March 26, 2021)

Description of Registrants Securities (Filed With SEC on February 26, 2021)

First through Sixth Amendments to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on February 26, 2021)

Consulting Agreement, dated July 15, 2020, between Prothena Biosciences Inc and Dennis J. Selkoe (Filed With SEC on February 26, 2021)

Third Amendment to the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on November 4, 2020)

First Amendment to the (Filed With SEC on August 6, 2020)

Form of Option Award Agreement (Filed With SEC on August 6, 2020)

First Amendment to the Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 22, 2020)

Offer Letter, dated February 18, 2020, between Prothena Biosciences Inc and Brandon S. Smith (Filed With SEC on May 6, 2020)

Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on May 6, 2020)

Option Award Agreement, dated March 2, 2020, between Prothena Corporation plc and Brandon S. Smith under the Prothena Corporation plc 2020 Employment Inducement Incentive Plan (Filed With SEC on May 6, 2020)

Understanding Related to License, Development, and Commercialization Agreement, dated as of March 1, 2020, among Prothena Biosciences Limited, Prothena Biosciences Inc, F.... (Filed With SEC on May 6, 2020)

License Agreement, dated as of March 1, 2020, between Prothena Biosciences Limited and F. Hoffmann-La Roche Ltd (Filed With SEC on May 6, 2020)

Amendment to License, Development, and Commercialization Agreement, entered into on October 1, 2019, among Prothena Biosciences Limited, Prothena Biosciences Inc, F. Hoffman-La... (Filed With SEC on March 3, 2020)

Release Agreement, dated October 1, 2019, between Prothena Biosciences Inc and A. W. Homan (Filed With SEC on March 3, 2020)

Engagement Agreement, dated October 2, 2019, between Prothena Biosciences Inc and A. W. Homan (Filed With SEC on March 3, 2020)

Amended and restated retirement transition letter, dated July 1, 2019, between Prothena Biosciences Inc and A.W. Homan (Filed With SEC on November 5, 2019)

Consulting Agreement, dated July 1, 2019, between Prothena Biosciences Inc and Dennis J. Selkoe (Filed With SEC on November 5, 2019)

Offer letter, dated June 4, 2019, between Prothena Biosciences Inc and Michael J. Malecek (Filed With SEC on August 6, 2019)

Retirement transition letter, dated December 11, 2018, between Prothena Biosciences Inc and A. W. Homan (Filed With SEC on March 15, 2019)

Promotion letter, dated December 11, 2018, between Prothena Biosciences Inc and Radhika Tripuraneni (Filed With SEC on March 15, 2019)

Termination and Release Agreement, dated July 20, 2018, between Prothena Biosciences Limited and Rentschler Biopharma SE (Filed With SEC on November 6, 2018)

Separation Agreement, dated May 23, 2018, between Prothena Biosciences Inc and Tara Nickerson (Filed With SEC on August 7, 2018)

Form of Option Award Agreement between Prothena Corporation plc and Registrants Non-Employee Directors under the Prothena Corporation plc 2018 Long Term Incentive Plan (used... (Filed With SEC on August 7, 2018)

Form of Option Award Agreement between Prothena Corporation plc and Registrants Named Executive Officers under the Prothena Corporation plc 2018 Long Term Incentive Plan (used... (Filed With SEC on August 7, 2018)

Prothena Corporation plc 2018 Long Term Incentive Plan (Filed With SEC on May 18, 2018)

License Agreement, dated as of November 4, 2013, between The Regents of the University of California and Neotope Biosciences Limited (Filed With SEC on May 9, 2018)

License Agreement Amendment Number One, dated as of January 15, 2014, to License Agreement dated as of November 4, 2013, between The Regents of the University of California and... (Filed With SEC on May 9, 2018)

Exclusive License Agreement, dated as of July 25, 2016, between University Health Network and Prothena Biosciences Limited (Filed With SEC on May 9, 2018)

Confidential Treatment Requested by Prothena Corporation plc (Filed With SEC on August 9, 2017)

PROTHENA CORPORATION PLC AMENDED AND RESTATED 2012 LONG TERM INCENTIVE PLAN (as amended and restated as of February 22, 2017) (Filed With SEC on May 23, 2017)

PROTHENA CORPORATION PLC AMENDED AND RESTATED INCENTIVE COMPENSATION PLAN (Filed With SEC on May 9, 2017)

PROTHENA CORPORATION PLC (anIrish public limited company) 2,700,000 Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on March 8, 2017)

Confidential Treatment Requested by Prothena Corporation plc (Filed With SEC on February 27, 2017)

Prothena Biosciences Inc 650 Gateway Boulevard South San Francisco, CA 94010 U.S.A. (Filed With SEC on November 28, 2016)

Employment Agreement (Filed With SEC on November 4, 2016)

PROTHENA CORPORATION PLC AMENDED AND RESTATED 2012 LONG TERM INCENTIVE PLAN (as amended and restated as of May 19, 2016) (Filed With SEC on May 25, 2016)

PROTHENA BIOSCIENCES INC AMENDED AND RESTATED SEVERANCE PLAN ATTACHMENT I (Filed With SEC on May 4, 2016)

PROTHENA CORPORATION PLC (anIrish public limited company) 2,250,000 Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on January 7, 2016)

Prothena Biosciences Inc Amended and Restated Severance Plan TABLE OF CONTENTS PageARTICLE IINTRODUCTION1ARTICLE IIDEFINITIONS1ARTICLE IIIELIGIBILITY5ARTICLE IVPAY AND BENEFITS IN... (Filed With SEC on December 15, 2015)

PROTHENA CORPORATION PLC (anIrish public limited company) 3,300,000 Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on April 13, 2015)

Form of Option Award Agreement between Prothena Corporation plc and Registrants Named Executive Officers (used beginning February 4, 2014) PROTHENA CORPORATION PLC 2012 LONG TERM... (Filed With SEC on March 13, 2015)

DEED OF INDEMNIFICATION (Filed With SEC on December 11, 2014)

PROTHENA CORPORATION PLC (an Irish public limited company) 4,750,000 Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on June 25, 2014)

LICENSE, DEVELOPMENT, AND COMMERCIALIZATION AGREEMENT BY AND BETWEEN NEOTOPE BIOSCIENCES LIMITED AND PROTHENA BIOSCIENCES INC, on the one hand, AND F. HOFFMANN-LA ROCHE LTD AND... (Filed With SEC on March 7, 2014)

PROTHENA CORPORATION PLC (anIrish public limited company) 2,767,177 Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on January 29, 2014)

FOURTH AMENDMENT TO LEASE (Filed With SEC on December 5, 2013)

PROTHENA CORPORATION PLC (anIrish public limited company) Ordinary Shares UNDERWRITING AGREEMENT (Filed With SEC on September 30, 2013)

AMENDMENT NUMBER ONE AMENDED AND RESTATED INTELLECTUAL PROPERTY LICENSE AND CONTRIBUTION AGREEMENT (Filed With SEC on September 30, 2013)

AMENDMENT NO. 1 TO TAX MATTERS AGREEMENT (Filed With SEC on August 13, 2013)

PROTHENA BIOSCIENCES INC AMENDED AND RESTATED SEVERANCE PLAN TABLE OF CONTENTS (Filed With SEC on March 29, 2013)

REVISED December 21, 2012 (Filed With SEC on March 29, 2013)

Employment Agreement (Filed With SEC on January 25, 2013)

AMENDED AND RESTATED INTELLECTUAL PROPERTY LICENSE AND CONTRIBUTION AGREEMENT AMONG NEOTOPE BIOSCIENCES LIMITED AND ELAN PHARMA INTERNATIONAL LIMITED AND ELAN PHARMACEUTICALS,... (Filed With SEC on December 21, 2012)

INTELLECTUAL PROPERTY LICENSE AND CONVEYANCE AGREEMENT AMONG NEOTOPE BIOSCIENCES LIMITED AND ELAN PHARMA INTERNATIONAL LIMITED AND ELAN PHARMACEUTICALS, INC. Dated as of December... (Filed With SEC on December 21, 2012)

ASSET PURCHASE AGREEMENT (Filed With SEC on December 21, 2012)

TAX MATTERS AGREEMENT by and between ELAN CORPORATION, PLC AND PROTHENACORPORATION PLC, Dated 20 December 2012 TABLE OF CONTENTS (Filed With SEC on December 21, 2012)

DATED 20 DECEMBER 2012 Elan Corporation Plc and Prothena Corporation Plc TRANSITIONALSERVICES AGREEMENT Subject to Contract A & L GOODBODY (Filed With SEC on December 21, 2012)

20 December 2012 ELAN CORPORATION PLC AND PROTHENA CORPORATION PLC RESEARCH AND DEVELOPMENT SERVICES AGREEMENT Contents (Filed With SEC on December 21, 2012)

PROTHENA CORPORATION PLC 2012 LONG TERM INCENTIVE PLAN TABLE OF CONTENTS (Filed With SEC on December 21, 2012)

PROTHENA BIOSCIENCES INC SEVERANCE PLAN TABLE OF CONTENTS (Filed With SEC on December 21, 2012)

PROTHENA CORPORATION PLC INCENTIVE COMPENSATION PLAN (Filed With SEC on December 21, 2012)

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Prothena Corp plc Contracts & Agreements