PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.

Exhibit 10.190

Amended and Restated Effective January 1, 2005

The name of this plan is the Pharmaceutical Product Development, Inc. Deferred Compensation Plan for Executives (the “Plan”). Its purpose is to provide certain select management or highly compensated employees on the payroll of either Pharmaceutical Product Development, Inc. (the “Company”) or a subsidiary of the Company (the “Affiliates”) with the opportunity to defer (i) compensation earned as an employee, and (ii) shares of Company stock received upon the lapse of restrictions on restricted stock of the Company. The Plan is intended and designed to comply with Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”), and to be an amendment and restatement of the predecessor plan, the Pharmaceutical Product Development, Inc. Deferred Compensation Plan (the “Prior Plan”) whose terms were frozen and grandfathered under prior law effective as of December 31, 2004.

The Plan shall be amended and restated effective as of January 1, 2005.

All employees who are officers, executive or senior vice presidents, vice presidents, and executive directors of the Company or an Affiliate who are receiving compensation in the United States from the Company or an Affiliate (“Employees”) shall be eligible to participate in the Plan. Any such Employee who elects to participate in the Plan is hereinafter called a “Participant.” Any Employee who participated in the Prior Plan as of December 31, 2004 shall automatically become a Participant in this Plan as of January 1, 2005. The Company will establish for each Participant one or more unfunded deferred compensation accounts, as specified in Articles V and VII.

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Account during such quarter and after crediting the Cash Compensation Deferral Account with fifty percent of the deferrals for such calendar quarter. Interest for each calendar quarter shall be based on the three month London Interbank Offered Rate (or similar index designated by the Committee) plus one and one-half percent (1.5%).

Common Stock. “Common Stock” shall mean the common stock of Pharmaceutical Product Development, Inc., $0.10 par value per share.

Restricted Stock/Restricted Stock Award. “Restricted Stock” or “Restricted Stock Award” shall mean a share of restricted Common Stock that was granted to an Employee under a Stock Plan.

Restricted Stock Deferral Agreement. “Restricted Stock Deferral Agreement” shall mean the form established from time to time by the Committee that an Employee completes, executes, and returns to the Committee to defer the receipt of shares of Common Stock upon the lapse of restrictions on Restricted Stock Awards.

Restricted Stock Unit/RSU. “Restricted Stock Unit” or “RSU” shall mean units of deemed investment in shares of Common Stock in accordance with Article VII of the Plan.

Restricted Stock Unit Account/RSU Account. “Restricted Stock Unit Account” or “RSU Account” shall mean the record of a Participant’s interest in this Plan represented by the number of RSUs related to shares of Restricted Stock deferred hereunder, adjusted for distributions, withdrawals, and other similar activities as provided in the Plan.

Stock Plan. “Stock Plan” shall mean collectively the equity incentive plans adopted by the company from time to time or under which the Company has Restricted Stock Awards outstanding, and individually, such equity incentive plan governing any particular Restricted Stock Award.

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Deferral Agreement, Restricted Stock Deferral Agreement, or other appropriate form designated by the Committee, the date upon which the entire amount of the applicable Cash Compensation Deferral Account and/or Restricted Stock Unit Account shall become payable. In the event of the Participant’s termination of employment following the attainment of age 55 and the completion of 10 years service (a “qualified termination event”), a Participant may designate separately with respect to each Cash Compensation Deferral Account and/or Restricted Stock Unit Account that payment of each such Cash Compensation Deferral Account and/or Restricted Stock Unit Account commence upon (a) a date certain specified by the Participant that is at least two (2) years following the effective date of the deferral related to that Cash Compensation Deferral Account and/or Restricted Stock Unit Account but not more than 10 years after the termination of employment from the Company or an Affiliate, or (b) the date of the Participant’s termination of employment. In the event of the Participant’s termination of employment prior to attaining the age of 55 and completing ten (10) years of service, the balance of all of the Participant’s Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts shall be paid in a lump sum within 30 days of the date of the Participant’s termination of employment. Notwithstanding anything in this Section VIII.A to the contrary, (i) in the event of a Participant’s death, the balance of all of the Participant’s Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts shall be distributed pursuant to the terms of Article X; (ii) in the event of a Participant’s Disability (as defined hereinafter), the balance of all of the Participant’s Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts shall be distributed pursuant to the terms of Article XI; (iii) in the case of a Participant who is a “key employee,” no distribution shall be made before the date which is six (6) months after the date of separation from service (or, if earlier, the date of death of the Participant). For purposes of subsection (iii) of this Section VIII.A, the distribution restriction shall apply during a given calendar year with respect to any Participant who is identified as being a “key employee” (as defined in Code Section 416(i), without regard to paragraph (5) thereof) during the twelve-month period ending on September 30th of immediately preceding calendar year.

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event a Participant has not made an election under Section VIII.A or Section VIII.B, then the Participant shall be treated as having a qualified termination event on the date of the Participant’s termination of employment under Section VIII.A above; and a form of payment of a lump sum under Section VIII.B above.

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Company that, together with stock held by such person or group, constitutes more than 50 percent of the total fair market value or total voting power of the stock of the Company;

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designated by the Committee, in its discretion, at the time of any distribution or withdrawal hereunder, as reasonably expected not to be such a “covered employee” with respect to the current taxable year of the Company and (b) any individual who is designated by the Committee, in its discretion, at the time of any distribution or withdrawal, as reasonably expected to be such a “covered employee” with respect to the current taxable year of the Company or with respect to the taxable year of the Company in which any applicable distribution or withdrawal will be paid);

Notwithstanding anything contained in Section VIII.A or Section VIII.B to the contrary, if any Participant dies before receiving all amounts credited to each of his Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts, the unpaid amounts in the Participant’s Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts shall be paid as follows: (i) if the death occurs on or after the Participant has attained age 55 and completing ten (10) years of service, then the death benefit shall be payable pursuant to the terms of Article VIII hereof, treating the date of death as being the Participant’s qualified termination event; or (ii) if the death of the Participant occurs prior to the Participant attaining age 55 and completing ten (10) years of service, then the death benefit shall be payable on the first business day coinciding with or next following the 30th day following the date of death in the form elected under Section

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VIII.B. Any death benefit payable under this Article X shall be paid to the Participant’s beneficiary or beneficiaries in accordance with the last effective beneficiary designation form filed by the Participant with the Committee. Each Participant shall file with the Committee a form indicating the person, persons, or entity who is to receive the Participant’s benefits under the Plan if he dies before receiving all the balances in his Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts. A Participant’s beneficiary designation may be changed at any time prior to his death by execution and delivery of a new beneficiary designation form. If a Participant has failed to designate a beneficiary or no designated beneficiary survives the Participant, payment shall be made in a lump sum to the Participant’s surviving spouse. If the Participant has no surviving spouse, the benefits remaining under the Plan to be paid to a beneficiary shall be payable to the executor or personal representative of the Participant’s estate. A beneficiary who fails to survive a Participant by at least 10 days shall be deemed to have predeceased the Participant.

Notwithstanding anything contained in Section VIII.A or Section VIII.B to the contrary (except for the distribution restriction described in subsection (iii) of Section VIII.A. that will continue to apply), in the event of the Disability of a Participant, all amounts credited to each of the Participant’s Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts, and remaining unpaid on the date of the onset of the Disability shall be paid to the Participant as follows: (i) if the Disability occurs on or after the Participant has attained age 55 and completing ten (10) years of service, then the disability benefit shall be payable pursuant to the terms of Article VIII hereof, treating the date of the onset of the Disability as being the Participant’s qualified termination event; or (ii) if the Disability of the Participant occurs prior to the Participant attaining age 55 and completing ten (10) years of service, then the disability benefit shall be payable on the earlier of the attainment of age 55 and completing ten (10) years of service or the cessation of benefit payments to the Participant under any Company long-term disability plan, in the form elected under Section VIII.B. For purposes of this Article XI of the Plan, “Disability” shall mean (a) the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or can be expected to last for a continuous period of not less than 12 months, or (b) is, by reason of any medically determinable physical or mental impairment which can be expected to result in death or can be expected to last for a continuous period of not less than 12 months, receiving income replacement benefits for a period of not less than three (3) months under the long-term disability plan of the Company.

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XIII. PARTICIPANT’S RIGHTS

Establishment of the Plan shall not be construed to give any Participant the right to be retained in the Company’s or an Affiliate’s service or to any benefits not specifically provided by the Plan. A Participant shall not have any interest in the deferred compensation and earnings credited to his Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts until such accounts are distributed in accordance with the Plan. All amounts deferred or otherwise held for the account of a Participant under the Plan shall remain the sole property of the Company, subject to the claims of its general creditors and available for its use for whatever purposes are desired. With respect to amounts deferred or otherwise held for the account of a Participant, the Participant is merely a general creditor of the Company; and the obligation of the Company hereunder is purely contractual and shall not be funded or secured in any way. At its discretion, the Company may establish one or more grantor trusts to assist the Company in accumulating the funds needed to meets its obligation under the Plan.

In case the claim of any Participant or beneficiary for benefits under the Plan is denied, the Committee shall provide adequate notice in writing to such claimant, setting forth the specific reasons for such denial. The notice shall be written in a manner calculated to be understood by the claimant. The Committee shall afford a Participant or beneficiary whose claim for benefits has been denied 60 days from the date notice of such denial is delivered or mailed in which to appeal the decision in writing to the Committee. If the Participant or beneficiary appeals the decision in writing within 60 days, the Committee shall review the written comments and any submissions of the Participant or beneficiary and render its decision regarding the appeal all within 60 days of such appeal.

XIV. NON-ALIENABILITY AND NON-TRANSFERABILITY

The rights of a Participant to the payment of deferred compensation as provided in the Plan shall not be assigned, transferred, pledged, or encumbered, or be subject in any manner to alienation or anticipation. No Participant may borrow against his Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts. No Account and/or Restricted Stock Unit Account shall be subject in any manner to anticipation, alienation, sale, transfer, assignment, pledge,

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encumbrance, charge, garnishment, execution, or levy of any kind, whether voluntary or involuntary, including any liability which is for alimony or other payments for the support of a spouse or former spouse, or for any other relative of any Participant.

XV. STATEMENT OF ACCOUNT

Statements will be sent to Participants within 60 days after the end of each calendar quarter as to the balance in their Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts as of the end of such calendar quarter.

XVI. ADMINISTRATION

The Administrator of the Plan shall be the Benefits Administrative Committee of the Company or any successor committee (the “Committee”). The Committee shall have authority to adopt rules and regulations for carrying out the Plan and to interpret, construe, and implement the provisions thereof. Any decision or interpretation of any provision of the Plan adopted by the Committee shall be final and conclusive.

XVII. AMENDMENT AND TERMINATION

The Plan may, at any time, be amended or modified by the Board of Directors of the Company. The Board of Directors of the Company may terminate the Plan and distribute all benefits accrued hereunder only: (i) if the termination is in connection with a Change in Control pursuant to the terms of Section VIII.E, within 12 months of a corporate dissolution taxed under Code Section 331, or with the approval of a bankruptcy court pursuant to 11 U.S.C. Section 503(b)(1)(A); or (ii) if all nonqualified deferred compensation plans that are account balance plans maintained by the Company are terminated, no payments are made within 12 months of the termination of the Plan (other than those that would have been paid absent the termination), all payments are made within 24 months of the termination of the Plan, and the Company does not adopt another nonqualified deferred compensation plan that is an account balance plan for a period of five (5) years following the date of the termination of the Plan. No amendment, modification, or termination shall, without the consent of a Participant, adversely affect such Participant’s right to receive amounts previously accrued in his Cash Compensation Deferral Accounts and/or Restricted Stock Unit Accounts. Furthermore, unless explicitly provided otherwise, no amendment, modification, or termination of this Plan shall affect the Prior Plan whose terms were frozen and grandfathered under prior law effective as of December 31, 2004.

XVIII. GENERAL PROVISIONS

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Any and all payments made to the Participant pursuant to the Plan shall be made only from the general assets of the Company, or at the discretion of the Company, such payments shall be made from a grantor trust established by the Company. All accounts under the Plan shall be for bookkeeping purposes only and shall not represent a claim against specific assets of the Company. Nothing contained in this Plan shall be deemed to create a trust of any kind or create any fiduciary relationship.

IN WITNESS WHEREOF, Pharmaceutical Product Development, Inc. has caused its corporate seal to be hereunto affixed and has caused its name to be signed hereto by its Chief Executive Officer and attested by its Secretary, pursuant to due authority of its Board of Directors as of this 1^st day January, 2005.

(Corporate Seal)

Attest:

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