Fifth Amendment to Lease for facilities at 1310 Harbor Bay Parkway, Alameda, California, dated April 1, 2022

THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is made as of April 1, 2022 (the “Fifth Amendment Effective Date”), by and between HARBOR BAY CA LLC, a Delaware limited liability company (“Landlord”), and PENUMBRA, INC., a Delaware corporation (“Tenant”).

NOW, THEREFORE, in consideration of the mutual agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties do hereby agree as follows:

“The entire Building, as further set forth in Exhibit A to this Lease, which contains approximately 129,129 rentable square feet.”

“(kk)    fees payable by Landlord for management of the Project in excess of three percent (3%) of Rent, adjusted to reflect Tenant paying full rent, as contrasted with free rent, half-rent and the like, including Base Rent and Additional Rent, for any calendar year or portion thereof.

If Landlord is not furnishing any particular work or service (the cost of which, if performed by Landlord, would be included in Operating Expenses) to a tenant who has undertaken to perform such work or service in lieu of the performance thereof by Landlord, such expenses (inclusive, for example, of the cost of the work or services to be performed by Tenant pursuant to the terms of Section 2(a) of the Fourth Amendment) shall not be included in the calculation of Operating Expenses (and, accordingly, will not be included in the calculation of Additional Rent for the purposes of determining the management fees payable to Landlord as described above) for so long as such tenant performs such work or service.”

IN WITNESS WHEREOF, the parties hereto have executed this Fifth Amendment as of the Fifth Amendment Effective Date.