First Amendment to Lease for facilities at 1310 Harbor Bay Parkway, Alameda, California, dated April 10, 2020

THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made and entered into on April 10, 2020 (the “First Amendment Date”) by and between SOUTH LOOP 1, LLC, a Delaware limited liability company (“Landlord”), and PENUMBRA, INC., a Delaware corporation (“Tenant”).

A.Landlord and Tenant entered into that certain Lease dated September 3, 2019 (the “Lease”), with respect to certain premises known as 1310 Harbor Bay Parkway, Alameda, California, and as more particularly described in the Lease.

B.In light of the disruptions and potential delays that the COVID-19 pandemic (the “2020 Pandemic”) has caused and in anticipation of the potential for additional disruptions and delays, Landlord and Tenant have agreed to make certain amendments and modifications to the Lease in certain respects, and otherwise ratify all the terms, conditions and covenants as set forth therein.

NOW THEREFORE, in consideration of good and valuable consideration and the mutual agreements herein contained, and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties do hereby agree as follows:

1.Defined Terms. All capitalized terms used but not defined in this First Amendment will have the meanings set forth for such terms in the Lease. All terms that are defined in this First Amendment and used in any provisions that are added to the Lease pursuant to this First Amendment will have the meanings set forth for such terms in this First Amendment.

2.Force Majeure Definition. The first sentence of Section 29.16 of the Lease is hereby amended to insert the words “epidemics or pandemics caused by communicable diseases” immediately following the words “terrorist acts”.

3.Required Performance Dates. Section 5.5 of the Tenant Work Letter, which was attached to the Lease as Exhibit B, is hereby deleted and replaced in its entirety with the following:

“5.5 Required Performance Dates.

4.Progress Schedule. The Progress Schedule that was attached as Schedule 2 to the Tenant Work Letter, which was attached to the Lease as Exhibit B, contained errors, and is hereby deleted and replaced in its entirety with the Progress Schedule attached hereto as Schedule 2 (the “Corrected Progress Schedule”). The parties acknowledge and agree that the Corrected Progress Schedule does not account for the 2020 Pandemic, and that as detailed in the letter from Landlord to Tenant dated March 19, 2020, the 2020 Pandemic may affect the construction of the Improvements. Tenant acknowledges that, as a result of the 2020 Pandemic, a Force Majeure event has occurred and began on March 17, 2020. Tenant further acknowledges and agrees that, in addition to the provisions contained in Sections 1.4 and 3.2 of the Tenant Work Letter regarding changes to the Progress Schedule, the Progress Schedule will need to be revised in response to the 2020 Pandemic.

5.Damage and Destruction. The last sentence of Section 11.2 of the Lease is hereby deleted and replaced in its entirety with the following:

“In addition, if restoration is not substantially complete on or before the later of (i) the date that occurs fifteen (15) months after the date of discovery of the damage, and (ii) the date that occurs ninety (90) days after the expiration of the estimated period of time to substantially complete such restoration, as set forth in Landlord’s Completion Notice (the “Outside Restoration Date”), which Outside Restoration Date shall be extended to the extent of any delays (x) caused by Tenant or (y) caused by Force Majeure (up to a maximum of sixty (60) days of additional delay due to Force Majeure, provided that there shall be no such maximum for Force Majeure delays due to epidemics or pandemics caused by communicable diseases such as, but not limited to, the 2020 Pandemic), then Tenant shall have the additional right during the first ten (10) business days following the Outside Restoration Date until such repairs are complete, to terminate this Lease by delivery of written notice to Landlord (the “Damage Termination Notice”), which termination shall be effective on a date specified by Tenant in such Damage Termination Notice (the “Damage Termination Date”), which Damage Termination Date shall not be less than ten (10) business days, nor greater than thirty (30) days, following the date such Damage Termination Notice was delivered to Landlord.”

6.Whole Agreement. This First Amendment sets forth the entire agreement between the parties with respect to the matters set forth herein. There have been no additional oral or written representations or agreements with respect thereto. Except as amended herein, or in a future writing signed by both parties, there shall be no other changes or modifications to the Lease between the parties and the Lease and the terms and provision contained therein shall remain in full force and effect. The terms of this First Amendment will control over any conflicts between it and the terms of the Lease.

7.Successors and Assigns. This First Amendment shall be binding upon the parties hereto, their heirs, successors and assigns.

8.Ratification. Except as amended by this First Amendment, the Lease has not been amended, and the parties ratify and confirm the Lease, as amended by this First Amendment, as being in full force and effect.

9.Counterparts; Electronic Execution. This First Amendment may be executed in counterparts, each of which will constitute an original, but all of which, when taken together, will constitute but one agreement. Executed copies hereof may be delivered by email or other electronic means, and upon receipt will be deemed originals and binding upon the parties hereto, regardless of whether originals are delivered thereafter.