Third Amendment to the Amended and Restated Manufacturing and Services Agreement, by and between the Company and CIPAN - Companhia Industrial Produtora de Antibiticos, S.A., dated as of July 28, 2020

Third Amendment to the Agreement. The Agreement is amended and modified as follows:

The terms set forth on Exhibit A of this Third Amendment are hereby added as a new Exhibit F of the Agreement.

The following provision is hereby added as the new Section 1.3:

“1.3 Appendix Terms. Notwithstanding anything to the contrary in the Agreement, the Parties acknowledge and agree to comply with any covenants set forth in Exhibit F. The Parties further acknowledge and agree that any representations and warranties set forth in Exhibit F are true and correct as of the Effective Date (as defined therein) of the Third Amendment. The provisions in Exhibit F will control over other provisions in this Agreement to the extent of any conflict.”

General Provisions. Unless specifically modified or changed by the terms of the Third Amendment, all terms and conditions of the Agreement and the Quality Agreement, between the Parties, dated as of November 2, 2016 (as may be amended from time to time, “Quality Agreement”) shall remain in full force and effect and shall apply fully as described and set forth in the Agreement and Quality Agreement, respectively. In the event of any express conflict or inconsistency between the Third Amendment, on one hand, and the Agreement or Quality Agreement on the other hand, the terms and conditions of the Third Amendment shall control. This Third Amendment, the Quality Agreement and the Agreement constitute the entire understanding among the parties regarding subject matters contained therein and herein and supersede all prior negotiations, commitments, agreements and understandings among them on such subject matters. This Third Amendment may be executed in any number of counterparts, either by original or facsimile counterpart, each such counterpart shall be deemed to be an original instrument, and all such counterparts together shall constitute but one agreement. This Third Amendment and all acts and transactions pursuant hereto and the rights

EXCLUDED STATUS. Pursuant to FAR 52.209-6, Service Provider represents that, as of the date of the effective date of the Agreement, neither Service Provider or its subcontractor(s), nor any of Service Provider’s or its subcontractor’s respective principals, are debarred, suspended, or proposed for debarment by the U.S. Government. Service Provider must confirm this representation on the effective date of this Agreement if the effective date of this Agreement occurs after the date on which Service Provider executes this Agreement.

PAYMENTS TO INFLUENCE CERTAIN FEDERAL TRANSACTIONS. Pursuant to FAR 52.203-11 and FAR 52.203-12, Service Provider hereby certifies to the best of its knowledge and belief that no Federal appropriated funds have been or will be paid to any person influencing or attempting to influence an officer or employee of any U.S. agency, a Member of Congress, an

REPORTING EXECUTIVE COMPENSATION AND AWARD. Service Provider will provide PARATEK with any information necessary to satisfy PARATEK’s obligations under FAR 52.204-10 Reporting Executive Compensation and First-Tier Subcontract Awards (Oct 2018), including the information specified in FAR 52.204-10(d)(2) and, if applicable, the information set forth in FAR 52.204-10(d)(3). Any information provided pursuant to this provision will be publicly disclosed.

NON-DISCRIMINATION AND OTHER LABOR REQUIREMENTS. Service Provider, if and to the extent applicable to it, and PARATEK will abide by the requirements of 41 C.F.R.

PROVISION OF INFORMATION TO THE U.S. GOVERNMENT. Service Provider acknowledges and agrees that information that Service Provider shares with PARATEK may be shared with the U.S. Government in connection with PARATEK’s performance of its agreement(s) with the U.S. Government. When appropriate, Service Provider may request that PARATEK provide specific information to the U.S. Government with restrictions on further disclosure of the information. PARATEK will not be responsible for any unauthorized use or disclosure of information by the U.S. Government or its agents or contractors.

CONFIDENTIAL TREATMENT OF SENSITIVE INFORMATION. Notwithstanding any other provision in this Agreement, Service Provider will, to the extent permitted by law, guarantee strict confidentiality of sensitive/confidential information that is provided by PARATEK from the

FINANCIAL CONFLICTS OF INTEREST. The Service Provider shall comply with requirements set forth in 45 C.F.R. Part 94 regarding financial conflicts of interest. Unless otherwise agreed with PARATEK, the Service Provider and its agents and employees will follow PARATEK’s conflict of interest policy under 45 C.F.R. Part 94. If PARATEK and the Service Provider agree that the Service Provider and its agents and employees will follow the Service Provider’s conflict of interest policy under 45 C.F.R. Part 94, the Service Provider hereby certifies that its conflict of interest policy complies with 45 C.F.R. Part 94. The Service Provider will submit all required reports to PARATEK at least fifteen calendar days before each report is due to the U.S. Government. The Service Provider understands and agrees, and will ensure that its employees and

PUBLICATIONS AND PRESS RELEASES. Service Provider must obtain PARATEK’s approval before publicly disclosing any publication or press release relating to this Agreement or Service Provider’s performance under this Agreement.

U.S. GOVERNMENT REPORTING. No confidentiality provision included in this Agreement may be construed to prohibit or otherwise restrict Service Provider, as a subcontractor of PARATEK under a U.S. Government contract, from lawfully reporting waste, fraud, or abuse to a designated investigative or law enforcement representative of the federal department or agency authorized to receive such information under the procurement involving the applicable PARATEK agreement(s) with the U.S. Government.

U.S. GOVERNMENT SITE VISITS, AUDITS, INSPECTIONS, AND COMMUNICATIONS. At the U.S. Government’s request, PARATEK and the U.S. Government together will have the right to conduct site visits, audits, and inspections at Service Provider’s facilities relating to PARATEK’s performance of this Agreement, including for the purpose of inventorying, with twenty-four hours’ advance notice or without notice with respect to time- sensitive or critical circumstances. If PARATEK or the U.S. Government identifies any issues during the visit, Service Provider will prepare a report describing the issues and identifying potential solutions. Service Provider will provide the report to PARATEK for review within seven business days of being notified of any issues. Once corrective action is taken in consultation with PARATEK, Service Provider will provide PARATEK with a follow-up report within seven business days.

PRIME CONTRACT AND QUALITY AGREEMENT. Service Provider will negotiate with PARATEK in good faith to make any revisions to this Agreement, including modifications to the cost or time required to complete work, that may be necessary based on future modifications to the applicable PARATEK agreement(s) with the U.S. Government or any quality agreement negotiated between PARATEK and the U.S. Government.

PRICING. Service Provider shall not under any circumstances bill PARATEK on an actual cost- plus-percentage-of-cost basis. Notwithstanding Service Provider’s standard pricing and billing practices, Service Provider shall also not charge PARATEK any premium for overtime. Service Provider shall ensure that no individual salary that exceeds the cap identified in HHSAR 352.231- 70 is charged to PARATEK or used by Service Provider to price services provided under this Agreement.

U.S. GOVERNMENT DISPUTES. Any dispute between Service Provider and PARATEK arising from the U.S. Government’s actions under the applicable PARATEK agreement(s) with the

Service Provider shall notify PARATEK of the dispute as soon as practicable, but in no event more than six months after Service Provider knew or should have known of the facts giving rise to such a dispute. Service Provider shall provide in the notice a written justification for and evidence supporting its position in the dispute and certify that it has a good faith basis to take this position.

Upon receiving a timely and complete notice from Service Provider, PARATEK will pursue relief under the Disputes clause in the applicable PARATEK agreement(s) with the

If Service Provider deems the contracting officer’s final decision in response to the sponsored claim to have an adverse effect on Service Provider’s position or rights, Service Provider and PARATEK will jointly determine in good faith whether to appeal the contracting officer’s final decision to the appropriate Board of Contract Appeals, the U.S. Court of Federal Claims, or any other forum that has jurisdiction over the contracting officer’s final decision. If Service Provider and PARATEK jointly agree to pursue such an appeal, Service Provider will be responsible for pursuing the appeal through PARATEK’s filings and will bear all expenses, including attorneys’ fees, arising from the appeal.

PARATEK will transfer any amounts that it receives in a dispute with the U.S. Government to Service Provider to the extent that such amounts reflect recovery for any portion of a claim representing Service Provider’s damages. PARATEK’s payment of such amounts will constitute complete satisfaction of any liability that PARATEK may have to Service Provider under this Agreement in connection with such a claim. PARATEK will also have no liability to Service Provider in connection with a claim brought under this Section to the extent that the U.S. Government issues a final decision denying such a claim after the decision is no longer appealable. In addition, PARATEK will have no liability to Service Provider with respect to any dispute that Service Provider fails to timely raise under this Section, except to the extent that PARATEK expressly agrees in writing to waive an applicable timeline.

NO SUPPORT OF TERRORISM. Service Provider acknowledges that U.S. executive orders and laws, including but not limited to Executive Order 13224 and Public Law 107-56, prohibit transactions with, and the provision of resources and support to, individuals and organizations associated with terrorism. It is the legal responsibility of Service Provider to ensure compliance with these executive orders and laws. This clause must be included in all subcontracts under this Agreement.

SECURITY INCIDENTS. Service Provider will provide PARATEK with notice within eighteen hours of any security incident—including violation of Service Provider’s established security standards, compromise, intrusion, loss of or interference with security processes and procedures, and the loss or theft of PARATEK or U.S. Government property—relating to the work performed under this Agreement. Service Provider will investigate security incidents to determine their cause, the extent, loss or compromise of sensitive program information, and corrective actions taken to prevent future incidents. Service Provider will advise PARATEK of the steps taken to resolve the security incident, including to mitigate future vulnerabilities. The U.S. Government may direct that this Agreement be terminated in response to a severe security incident in which case PARATEK will be authorized to immediately terminate this Agreement and Service Provider will be solely entitled to receive an amount that it would be entitled to receive under FAR 52.249-2 if this Agreement were a prime contract with the U.S. Government.

FOREIGN TRANSFERS.

Definition.

Export Controls.

Transfer of Products and Associated Technical Data.

Lower Tier Agreements.