Employment Offer Letter between V.I. Technologies, Inc. and Peyton J. Marshall, Ph.D. (August 2005)

Exhibit 10.2

Dear Peyton,

On behalf of V.I. Technologies, Inc. (“Vitex” or “the Company”), I am very pleased to extend an offer of employment to you. The following summarizes the terms of your anticipated employment with Vitex. Of course, not all of the terms and requirements of your employment can be set forth in this letter, and I encourage you to contact me or Stephen Andre in Human Resources with any questions you may have.

1. Position: Your initial position will be as Executive Vice President and Chief Financial Officer reporting to the CEO. As a Vitex employee, we expect that you will perform any and all duties and responsibilities normally associated with your position in a satisfactory manner and to the best of your abilities at all times. Your responsibilities will include Finance and Administration/Facilities, Investor Relations/Public Relations, and Information Technology.

2. Starting Date/Nature of Relationship: Your employment with Vitex will begin on August 17, 2005. No provision of this letter shall be construed to create an express or implied employment contract, or a promise of employment for any specific period of time. Your employment at Vitex is at-will employment, which may be terminated by you or Vitex at any time for any reason with or without advance notice.

3. Compensation/Benefits: Your initial Base Pay shall be annualized at $240,000 minus customary deductions for federal and state taxes and the like, and shall be paid in accordance with the Company’s usual payroll practices. Assuming you are still employed by Vitex at the time of payment, you will also be eligible to receive an Annual Cash Bonus targeted at 35% of your annual Base Pay, at the end of each calendar year that you are employed by the Company. The award and amount (which may be less than or greater than the target amount) of any Annual Cash Bonus shall be determined at the sole discretion of Vitex, based on the achievement of mutually agreed upon performance goals (both individual and Company) and your continued employment with the Company. Any Annual Cash Bonus will be paid within sixty (60) days following the end of the year to which it relates. Any annual Cash Bonus for 2005 will be pro-rated based on your start date.

In connection with your employment, and subject to approval of the Vitex Board of Directors, you will be granted an initial option to purchase 545,000 shares of common stock (“Initial Option Grant”) in Vitex at fair market value at the time of grant, pursuant to the terms of a formal stock option agreement. Neither the formal Stock Option Certificate nor any applicable Vitex stock plan creates any obligation on the Company’s part to employ you for any particular period of time. The options, which to the extent permitted by law shall be incentive stock options, will become exercisable on a time-based basis at the rate of 1/48^th per month beginning on September 17, 2005 and continuing as set forth in your stock option certificate. Subject to Section 5 below and the terms of your Stock Option Certificate and the applicable stock option plan, upon termination of employment, you shall have three months to exercise any unexercised, vested options.

In addition to your compensation, you may take advantage of various benefits offered by the Company, including Vitex’s medical, disability and life insurance, dependent care and medical flexible spending plans, 401(k) plan, and paid vacation and holiday time. These benefits, of course, may be modified or changed from time to time at the sole discretion of the Company. Vitex’s present benefit structure and other important information about the benefits for which you may be eligible are available from Human Resources. Where a particular benefit is subject to a formal plan (for example, medical insurance or life insurance), eligibility to participate in and receive any particular benefit is governed solely by the applicable plan document. Vacation and holidays are governed by Company policy. Subject to those policies, you will be eligible to accrue up to 4 weeks of vacation and 10 holidays each year. Should you ever have any questions about Vitex benefits, you should ask the Company for a copy of the applicable plan document or policy.

4. Confidentiality/Proof of Employability: Our offer is contingent on your execution of the attached Employee Non-Disclosure, Non-Competition and Inventions Agreement. This Agreement is necessary to protect the Company’s trade secrets, confidential information and/or goodwill. Also, your employment is contingent on your provision of all documents required to verify your eligibility to work in the United States.

5. Termination of Employment/Severance and Other Benefits: As stated, your employment with Vitex is at-will, which means that either you or Vitex may end the employment relationship at any time, for any reason, with or without notice. Not withstanding the foregoing, if you are terminated as set forth in this section, the Company will provide you with the severance and benefits set forth in this section, conditioned upon your timely execution of a separation agreement, in a form acceptable to the Company, containing a general release of claims against the Company.

a. If your employment is terminated by the Company without Cause (as defined in the Addendum, attached hereto) within three years of the start of your employment or if you resign for Good Reason (as defined in the Addendum) within three years of the start of your employment, then in exchange for a complete release of claims by you, the Company will pay you severance of six

month’s base pay, paid out over time in accordance with the Company’s then- current payroll practices, and will continue to pay its portion of the cost to continue your medical and dental coverage for six months following the termination date. In addition, you will have twelve months from the date of your termination to exercise any stock options that are exercisable as of your termination date, provided that such extension may cause the options to become non-qualified options.

b. If your employment is terminated by the Company without Cause (as defined in the Addendum, attached hereto) after the third anniversary of your first day of employment with the Company, or if you resign for Good Reason (as defined in the Addendum) after the third anniversary of your first day of employment with the Company, then in exchange for a complete release of claims by you, the Company will pay you severance of one year’s base pay, paid out over time in accordance with the Company’s then-current payroll practices, and will continue to pay its portion of the cost to continue your medical and dental coverage for one year following the termination date. In addition, you will have twelve months from the date of your termination to exercise any stock options that are exercisable as of your termination date, provided that such extension may cause the options to become non-qualified options.

c. If, within twelve months following a Change of Control (as defined in the Addendum), your employment is terminated by you for Good Reason (as defined in the Addendum) or by the Company for reasons other than Cause (as defined in the Addendum), then in lieu of 5(a) or 5(b) and in exchange for a complete release of claims by you, the Company will pay you severance of one year’s base pay, paid out over time in accordance with the Company’s then-current payroll practices, and will continue to pay its portion of the cost to continue your medical and dental coverage for one year following the termination date. In addition, any outstanding options shall become automatically exercisable at the time of such termination or resignation and shall be reflected in the terms of your Stock Option Certificate. You will have twelve months from the date of your termination to exercise any exercisable stock options.

6. Certifications: You hereby agree, represent and warrant that (i) neither your execution of this offer letter nor your becoming an employee of Vitex will cause you to be in violation of any post-employment restrictive covenants (e.g., non-competition/confidentiality agreements) with any prior employer; (ii) you understand that the Company will not ask for nor accept any confidential information belonging to any such employer; and (iii) you will honor all such valid agreements.

7. Miscellaneous: This letter, together with the attached Addendum, the Employee Non-Disclosure, Non-Competition and Inventions Agreement, and your Incentive Stock Option Certificate, constitutes our entire offer regarding the terms and conditions of your employment with the Company. It supersedes any prior agreements or other promises or statements (whether oral or written) regarding the offered terms of employment. As we have discussed, the Company intends to adopt, as soon as practicable, indemnification agreements for all of its officers, at which time you shall be offered such an agreement.

The terms of your employment shall be governed by the law of the Commonwealth of Massachusetts, without giving effect to conflict of law principles. By accepting this offer of employment, you agree that any action, demand, claim or counterclaim in connection with your employment with Vitex, or any separation of employment (whether voluntary or involuntary) from Vitex, shall be resolved in a court of competent jurisdiction in the Commonwealth of Massachusetts by a judge alone, and you waive and forever renounce your right to a trial before a civil jury.

You may accept this offer of employment and the terms and conditions hereof by signing the enclosed additional copy of this letter and returning it to Samuel Ackerman.

ADDENDUM – Definitions Applicable to Marshall Employment Agreement

(a) For purposes hereof, “Cause” shall mean willful misconduct by Marshall or willful failure by Marshall to perform his responsibilities to the Company (including, without limitation, breach by Marshall of any provision of any employment, consulting, advisory, non-disclosure, non-competition or other similar agreement between Marshall and the Company) that continues for fifteen (15) days after the CEO has given written notice to Marshall specifying in reasonable detail the manner in which Marshall has failed to perform such duties or comply with such directions.

i. a material or substantial diminution of Marshall’s responsibilities or the loss of the title of Chief Financial Officer, which the Company or its successor has failed to remedy within fifteen (15) days following Marshall’s delivery to the Company or its successor of written notice of such diminution of responsibilities or loss of title;

ii. an alteration of Marshall’s direct reporting structure such that he no longer reports directly to the CEO of the Company or its successor;

iii. a reduction in Marshall’s Base Pay following a merger or acquisition;

iv. any change to Marshall’s duties or the Company’s relocation, if such change would require excessive additional travel or relocation of Marshall’s sole assigned office to a location in excess of sixty (60) miles from Marshall’s principal residence as existed immediately prior to the date of such change; or

v. material breach by the Company or its successor of the terms of Marshall’s employment agreement with the Company or its successor (including the failure to grant equity promised thereunder).

(c) For purposes hereof, a “Change of Control” means the occurrence of any of the following events:

i. a merger or consolidation in which

1. the Company is a constituent party, or

2. a subsidiary of the Company is a constituent party and the Company issues shares of its capital stock pursuant to such merger or consolidation,

In the case of (1) or (2) above, except any such merger or consolidation involving the Company or a subsidiary in which the holders of capital stock of the Company immediately prior to such merger or consolidation continue to hold immediately following such merger or consolidation at

least 51%, by voting power and economic interest, of the capital stock of (A) the surviving or resulting entity or (B) if the surviving or resulting entity is a wholly owned subsidiary of another entity immediately following such merger or consolidation, the parent entity of such surviving or resulting entity; or

ii. the sale, in a single transaction or series of related transactions,

1. by the Company of all or substantially all of the assets of the Company (except where such sale is to a wholly owned subsidiary of the Company) or

2. by the stockholders of the Company of at least 51%, by voting power and economic interest, of the then-outstanding capital stock of the Company.