On an intent-to-treat basis, which includes all randomized patients who recorded at least one post-baseline body weight measurement, Contrave demonstrated mean weight loss of 4.0% of baseline body weight at 16 weeks and 5.2% at 24 weeks

EX-4.1 4 a25623a3exv4w1.htm EXHIBIT 4.1 exv4w1
 

EXHIBIT 4.1
CUSIP 686164 10 4

 

OREXIGEN THERAPEUTICS, INC.
The Corporation is authorized to issue more than one class of stock. The Corporation shall furnish without charge to each stockholder who so requests the powers, designations, preferences and relative, participating, optional, or other special rights of each class of stock of the Corporation or series thereof and the qualifications, limitations or restrictions of such preferences and/or rights. Such requests shall be made to the Corporation’s Secretary at the principal office of the Corporation.
The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations:
                                 
TEN COM   —   as tenants in common       UNIF GIFT MIN ACT —                                              Custodian                                           
TEN ENT   —   as tenants by the entireties           (Cust)
       (Minor)
JT TEN   —   as joint tenants with right of survivorship and not as tenants in common           under Uniform Gifts to Minors    
 
                  Act            
                         
                        (State)
Additional abbreviations may also be used though not in the above list.
FOR VALUE RECEIVED,                                                                                                                                      hereby sell(s), assign(s) and transfer(s) unto

PLEASE INSERT SOCIAL SECURITY OR OTHER
IDENTIFYING NUMBER OF ASSIGNEE

      
      


 
 
(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS INCLUDING POSTAL ZIP CODE OF ASSIGNEE)
 
 
     
 
  Shares
     
of the common stock represented by the within Certificate, and do(es) hereby irrevocably constitute and appoint
     
 
  Attorney
     
to transfer the said stock on the books of the within named Corporation with full power of substitution in the premises.
         
Dated
       
 
 
 
    
         
 
  X    
 
     
 
 
  X    
Signatures Guaranteed
  NOTICE:  
 
THE SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME(S) AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.
         
By
  
 
    
THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15.    
KEEP THIS CERTIFICATE IN A SAFE PLACE. IF IT IS LOST, STOLEN OR DESTROYED, THE CORPORATION WILL REQUIRE A BOND OF INDEMNITY AS A CONDITION TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE.