Opko Health, Inc. Contracts & Agreements

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OPKO HEALTH, INC. 3.00% CONVERTIBLE SENIOR NOTES DUE 2033 INDENTURE DATED AS OF JANUARY 30, 2013 WELLS FARGOBANK, NATIONAL ASSOCIATION TRUSTEE Table of Contents
Indenture Agreements
Opko Health, Inc.
Biotechnology
DE
2013
Note Purchase Agreement dated July 17, 2024 by and among the Company, certain purchasers party thereto, OPKO Biologics Limited, Eirgen Pharma Ltd. and HCR Injection SPV, LLC as...
Note Agreements
Opko Health, Inc.
2024
Form of Note dated July 17, 2024
Note Agreements
Opko Health, Inc.
2024
Asset Purchase Agreement, dated as of March 27, 2024 by and among BioReference Health, LLC, OPKO Health, Inc. and Laboratory Corporation of America Holdings
Purchase Agreements
Opko Health, Inc.
2024
Asset Purchase Agreement, dated as of March 27, 2024 by and among BioReference Health, LLC, OPKO Health, Inc. and Laboratory Corporation of America Holdings
Purchase Agreements
Opko Health, Inc.
2024
Indenture, dated January 9, 2024, by and between OPKO Health, Inc. and U.S. Bank Trust Company, National Association, as Trustee
Indenture Agreements
Opko Health, Inc.
2024
Purchase Agreement, dated January 4, 2024, by and between the Company and J.P. Morgan Securities LLC, as representative of the Initial Purchasers named therein
Purchase Agreements
Opko Health, Inc.
2024
Convertible Note Purchase Agreement, dated as of January 4, 2024, by and among the Company and certain investors, including Frost Gamma Investments Trust and Jane H. Hsiao, Ph.D.,...
Note Agreements
Opko Health, Inc.
2024
License and Research Collaboration Agreement by and between ModeX Therapeutics, Inc., OPKO Health, Inc. (with respect to certain sections), and Merck Sharp & Dohme LLC dated March...
Collaboration Agreements
Opko Health, Inc.
2023
Form of Amended 5% Convertible Promissory Note dated February 10, 2023
Note Agreements
Opko Health, Inc.
Biotechnology
NY
2023
Severance Agreement and General Release, dated August 16, 2022, by and among OPKO Health, Inc., BioReference Health, LLC and Jon R. Cohen, M.D
Severance Agreements
Opko Health, Inc.
2022
Settlement Agreement, dated July 14, 2022, by and among OPKO Health, Inc., BioReference Health, LLC, the United States of America, acting through the United States Department of...
Settlement Agreements
Opko Health, Inc.
2022
Corporate Integrity Agreement, dated July 14, 2022, by and among OPKO Health, Inc., BioReference Health, LLC and the Office of Inspector General of the United States Department of...
Services Agreements
Opko Health, Inc.
Biotechnology
2022
Agreement and Plan of Merger, dated as of May 9, 2022, by and among the Company, ModeX Therapeutics, Inc., Orca Acquisition Sub, Inc. and Gary J. Nabel, solely in the capacity of...
Merger Agreements
Opko Health, Inc.
2022
Lock-up and Voting Agreement, dated as of May 9, 2022, by and among the Company, Dr. Phillip Frost, Dr. Jane Hsiao and Frost Gamma Investments Trust
Voting Agreements
Opko Health, Inc.
2022
Offer Letter, dated May 9, 2022, by and between the Company and Dr. Zerhouni
Opko Health, Inc.
Biotechnology
FL
2022
Offer Letter, dated May 9. 2022, by and between the Company and Dr. Nabel
Opko Health, Inc.
Biotechnology
FL
2022
Waiver Under and Amendment No. 1 to Amended and Restated Credit Agreement, dated as of April 29, 2022, by and among BioReference Health LLC, GeneDx, LLC, the other subsidiary...
Loan Agreements
Opko Health, Inc.
Biotechnology
NJ
2022
Asset Purchase Agreement, dated June 16, 2021, among EirGen Pharma Limited, Horizon Therapeutics Ireland DAC, and OPKO Health, Inc. (with respect to certain sections)
Purchase Agreements
Opko Health, Inc.
2021
License Agreement by and among EirGen Pharma Limited and Nicoya Macua Limited, dated June 18, 2021
License Agreements
Opko Health, Inc.
2021
Exclusive License Agreement by and between OPKO Health, Inc. and CAMP4 Therapeutics Corporation, dated July 6, 2021
License Agreements
Opko Health, Inc.
Biotechnology
DE
2021
Form of Exchange Agreement, dated as of May 6, 2021, by and between OPKO Health Inc. and the applicable Noteholder
Exchange Agreements
Opko Health, Inc.
Biotechnology
NY
2021
Amendment No. 12 to Credit Agreement, dated as of March 12, 2021, by and among BioReference Laboratories, Inc., certain of its subsidiaries, and JPMorgan Chase Bank, N.A
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2021
Description of Securities
Opko Health, Inc.
2021
Amendment to Development and License Agreement between EirGen Pharma Ltd. and Vifor Fresenius Medical Care Renal Pharma Ltd., dated May 5, 2020
License Agreements
Opko Health, Inc.
Biotechnology
2020
Description of Securities
Opko Health, Inc.
2020
Amendment No. 10 to Credit Agreement by and between BioReference Laboratories, Inc. and certain of its subsidiaries, and JPMorgan Chase, N.A. dated November 4, 2019
Credit Agreements
Opko Health, Inc.
2020
Amendment No. 11 to Credit Agreement by and between BioReference Laboratories, Inc. and certain of its subsidiaries, and JPMorgan Chase, N.A. dated February 25, 2020
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2020
Credit Agreement, dated as of February 25, 2020, by and between OPKO Health, Inc. and Frost Gamma Investment Trust
Credit Agreements
Opko Health, Inc.
2020
Amendment No. 9 to Credit Agreement by and between BioReference Laboratories, Inc. and certain of its subsidiaries, and JPMorgan Chase, N.A. dated August 6, 2019
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2019
Underwriting Agreement, dated February 4, 2019, by and between the Company and Jefferies LLC
Underwriting Agreements
Opko Health, Inc.
2019
Amendment No. 8 to Credit Agreement by and between BioReference Laboratories, Inc. and certain of its subsidiaries, and JPMorgan Chase, N.A. dated February 26, 2019
Credit Agreements
Opko Health, Inc.
2019
Credit Agreement, dated as of November 8, 2018, by and between the OPKO Health, Inc. and Frost Gamma Investments Trust
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2019
Stock Purchase Agreement, dated as of November 8, 2018, between certain investors and OPKO Health, Inc
Stock Agreements
Opko Health, Inc.
Biotechnology
FL
2019
Underwriting Agreement, dated February 4, 2019, by and between the Company and Jefferies LLC
Underwriting Agreements
Opko Health, Inc.
2019
Base Indenture related to the 4.50% Convertible Senior Notes due 2025, dated as of February 7, 2019, by and between the Company and U.S. Bank National Association, as trustee
Indenture Agreements
Opko Health, Inc.
Biotechnology
DE
2019
Form of 4.50% Convertible Senior Notes due 2025 (incorporated herein by reference to Exhibit A of the First Supplemental Indenture filed as Exhibit 4.3 to this Current Report on...
Indenture Agreements
Opko Health, Inc.
Biotechnology
DE
2019
Share Lending Agreement, dated February 4, 2019, by and between the Company and Jefferies Capital Services, LLC
Share Agreements
Opko Health, Inc.
2019
Amendment No. 7 to Credit Agreement by and between BioReference Laboratories, Inc. and certain of its subsidiaries, and JPMorgan Chase, N.A. dated February 28, 2018
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2018
Development and License Agreement by and between EirGen Pharma Limited, a subsidiary of OPKO Health, Inc., and Japan Tobacco Inc., dated October 12, 2017
License Agreements
Opko Health, Inc.
2018
Amendment No. 5 to Credit Agreement, dated as of November 8, 2017, among Bio-Reference Laboratories, Inc. and certain of its subsidiaries and JPMorgan Chase Bank, N.A
Credit Agreements
Opko Health, Inc.
Biotechnology
NY
2018
Amendment No. 6 to Credit Agreement, dated as of December 22, 2017, among Bio-Reference Laboratories, Inc. and certain of its subsidiaries and JPMorgan Chase Bank, N.A
Credit Agreements
Opko Health, Inc.
Biotechnology
NY
2018
Form of 5% Convertible Promissory Note dated February 27, 2018
Note Agreements
Opko Health, Inc.
2018
Amendment No. 4 to Credit Agreement by and between Bio-Reference Laboratories, Inc. and certain of its subsidiaries and JPMorgan Chase Bank, N.A. dated August 7, 2017
Credit Agreements
Opko Health, Inc.
2017
Commitment Letter by and between OPKO Health, Inc. and Veterans Accountable Care Group, LLC, dated August 15, 2017
Opko Health, Inc.
Biotechnology
FL
2017
AMENDMENT NO. 3 TO CREDIT AGREEMENT
Credit Agreements
Opko Health, Inc.
2017
DEVELOPMENT AND LICENSE AGREEMENT BETWEEN OPKO HEALTH, INC. AND VIFOR FRESENIUS MEDICAL CARE RENAL PHARMA LTD May 8, 2016
License Agreements
Opko Health, Inc.
2016
ARRANGEMENT AGREEMENT BY AND AMONG OPKOHEALTH, INC., OPKO GLOBAL HOLDINGS, INC. AND TRANSITIONTHERAPEUTICS INC. Dated as of June 29, 2016 TABLE OF CONTENTS
Opko Health, Inc.
2016
CREDIT AGREEMENT dated as of November 5, 2015, among BIO-REFERENCE LABORATORIES, INC., as the Company, The Subsidiaries from time to time party hereto as Subsidiary Borrowers, The...
Loan Agreements
Opko Health, Inc.
2016
DATED 5 May, 2015 (1) SELLERS (2) OPKO IRELAND LIMITED (3) OPKO HEALTH, INC. AGREEMENT FOR THE SALE AND PURCHASE OF SHARES IN EIRGEN PHARMA LIMITED McCann FitzGerald Solicitors...
Purchase Agreements
Opko Health, Inc.
2015
DATED 5 May 2015 (1) SELLERS (2) OPKO IRELAND LIMITED FORM OF AGREEMENT FOR THE SALE AND PURCHASE OF SHARES IN EIRGEN PHARMA LIMITED McCann FitzGerald Solicitors Riverside One Sir...
Purchase Agreements
Opko Health, Inc.
2015
AGREEMENT AND PLAN OF MERGER BY AND AMONG OPKO HEALTH, INC., BAMBOO ACQUISITION, INC. AND BIO-REFERENCE LABORATORIES, INC. Dated as of June 3, 2015 TABLE OF CONTENTS
Merger Agreements
Opko Health, Inc.
2015
*** = Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the...
License Agreements
Opko Health, Inc.
Biotechnology
NY
2015
AMENDMENT TO THE OPKOHEALTH, INC. 2007 EQUITY INCENTIVE PLAN
Bonus & Incentive Agreements
Opko Health, Inc.
2013
SHARE PURCHASE AGREEMENT BY AND AMONG CYTOCHROMA INC., CYTOCHROMA HOLDINGS ULC, CYTOCHROMA CANADA INC. CYTOCHROMA DEVELOPMENT INC. PROVENTIV THERAPEUTICS, LLC CYTOCHROMA CAYMAN...
Share Agreements
Opko Health, Inc.
2013
AGREEMENT AND PLAN OF MERGER
Merger Agreements
Opko Health, Inc.
Biotechnology
OK
2013
NOTE PURCHASE AGREEMENT
Note Agreements
Opko Health, Inc.
2013
STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
Biotechnology
2012
STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
2012
AGREEMENT AND PLAN OF MERGER
Merger Agreements
Opko Health, Inc.
2011
ASSET PURCHASE AGREEMENT
Purchase Agreements
Opko Health, Inc.
Biotechnology
DE
2011
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
Biotechnology
FL
2011
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
2011
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
Biotechnology
FL
2011
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
2011
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
2010
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
2010
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
Biotechnology
DE
2010
FORM OF RESTRICTED STOCK AGREEMENT FOR DIRECTORS
Stock Agreements
Opko Health, Inc.
Biotechnology
FL
2009
R E C I T A L S
Opko Health, Inc.
2009
SECURITIES PURCHASE AGREEMENT dated as of September 18, 2009 by and among OPKO HEALTH, INC. AND THE PURCHASERS SET FORTH ON THE SIGNATURE PAGES HERETO
Purchase Agreements
Opko Health, Inc.
2009
COMMON STOCK WARRANT
Warrant Agreements
Opko Health, Inc.
Biotechnology
DE
2009
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
2009
We have a history of operating losses and we do not expect to become profitable in the near future
Opko Health, Inc.
Biotechnology
CA
2009
EX-31.1 Section 302 Certification of CEO
Opko Health, Inc.
2009
EX-31.1 Section 302 Certification of CEO
Opko Health, Inc.
Biotechnology
FL
2009
STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
2008
CONFIDENTIAL MATERIAL OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS. SECURITIES PURCHASE AGREEMENT
Exchange Agreements
Opko Health, Inc.
Biotechnology
FL
2008
DIRECTOR INDEMNIFICATION AGREEMENT
Indemnification Agreements
Opko Health, Inc.
2008
OFFICER INDEMNIFICATION AGREEMENT
Indemnification Agreements
Opko Health, Inc.
2008
AMENDED AND RESTATED BYLAWS OF OPKO HEALTH, INC. (A DELAWARE CORPORATION) Effective: March 28, 2008 Article I. OFFICES
Opko Health, Inc.
Biotechnology
2008
OPHTHALMIC TECHNOLOGIES INC. SHARE PURCHASE AGREEMENT April11, 2007 OPHTHALMIC TECHNOLOGIES INC SHARE PURCHASE AGREEMENT
Share Agreements
Opko Health, Inc.
2008
SHARE PURCHASE AGREEMENT November 28, 2007
Share Agreements
Opko Health, Inc.
Biotechnology
2008
OPKO HEALTH, INC. - and - OTI HOLDINGS LIMITED - and - EACH HOLDER OF EXCHANGEABLE SHARES in the capital of OTI Holdings Limited EXCHANGE AND SUPPORT AGREEMENT DATED: November 28,...
Exchange Agreements
Opko Health, Inc.
Biotechnology
2008
STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
Biotechnology
2008
OPKO HEALTH, INC. 2007 EQUITY INCENTIVE PLAN
Bonus & Incentive Agreements
Opko Health, Inc.
Biotechnology
FL
2008
OFFICE LEASE
Lease Agreements
Opko Health, Inc.
Biotechnology
2007
SETTLEMENT AGREEMENT AND GENERAL RELEASE
Settlement Agreements
Opko Health, Inc.
2007
EXEGENICS INC. 4400 Biscayne Blvd. Suite 900 Miami, Florida 33137
Opko Health, Inc.
2007
MERGER AGREEMENT AND PLAN OF REORGANIZATION
Merger Agreements
Opko Health, Inc.
Biotechnology
FL
2007
FORM OF COMMON STOCK WARRANT
Warrant Agreements
Opko Health, Inc.
Biotechnology
DE
2007
FORM OF SERIES C PREFERRED STOCK WARRANT
Warrant Agreements
Opko Health, Inc.
2007
FORM OF LOCKUP AGREEMENT
Opko Health, Inc.
2007
CREDIT AGREEMENT
Credit Agreements
Opko Health, Inc.
Biotechnology
FL
2007
AMENDED AND RESTATED VENTURE LOAN AND SECURITY AGREEMENT Executed as of March ___, 2007 Effective as of September 14, 2005 by and among
Loan Agreements
Opko Health, Inc.
Biotechnology
DE
2007
TECHNOLOGY LICENSE AGREEMENT
License Agreements
Opko Health, Inc.
Biotechnology
IL
2007
LICENSE AGREEMENT
License Agreements
Opko Health, Inc.
2007
AMENDMENT NO. 1 TO LICENSE AGREEMENT
License Agreements
Opko Health, Inc.
2007
AMENDMENT NO. 2 TO LICENSE AGREEMENT
License Agreements
Opko Health, Inc.
Biotechnology
2007
LICENSE AND COLLABORATION AGREEMENT
Collaboration Agreements
Opko Health, Inc.
2007
University of Pennsylvania
Opko Health, Inc.
2007
University of Pennsylvania
Opko Health, Inc.
2007
First Amendment to the License Agreement between the The Trustees of the University of Pennsylvania and Acuity Pharmaceuticals, Inc.
License Agreements
Opko Health, Inc.
2007
FirstAmendment to the License Agreement between the The Trustees of the University of Pennsylvania and Acuity Pharmaceuticals, Inc.
License Agreements
Opko Health, Inc.
Biotechnology
2007
AMENDED AND RESTATED SUBORDINATION AGREEMENT
Subordination Agreement
Opko Health, Inc.
Biotechnology
DE
2007
EXEGENICS INC. 4400 Biscayne Blvd Suite 900 Miami, Florida 33137
Opko Health, Inc.
2007
EMPLOYMENT AGREEMENT
Employment Agreements
Opko Health, Inc.
2007
AMENDMENT TO STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
2006
STOCK PURCHASE AGREEMENT
Stock Agreements
Opko Health, Inc.
2006
EX-10.1 Separation Agreement
Separation Agreements
Opko Health, Inc.
2005
EX-10.2 Agreement Between eXegenics and D. Hostelley
Opko Health, Inc.
Biotechnology
2005
INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT
Assignment Agreements
Opko Health, Inc.
2004
SUBLEASE
Lease Agreements
Opko Health, Inc.
Biotechnology
2004
Form of Warrant Agreement - Gruntal & Co., LLC
Warrant Agreements
Opko Health, Inc.
2004
Form of Warrant Agreement - Roan Meyers Associates
Warrant Agreements
Opko Health, Inc.
Biotechnology
NY
2004
Form of Warrant Agreement - Petkevich & Partners
Warrant Agreements
Opko Health, Inc.
2004
Promissory Note and Pledge Agreement
Note Agreements
Opko Health, Inc.
Biotechnology
TX
2004
Amendment to Employment Agreement - David E Riggs
Employment Agreements
Opko Health, Inc.
2004
Termination Letter - Dorit Arad
Termination Agreements
Opko Health, Inc.
Biotechnology
2004
Termination Letter - Joan Gillett
Termination Agreements
Opko Health, Inc.
Biotechnology
2004
Separation from Employment Letter - Arthur Bollon
Separation Agreements
Opko Health, Inc.
2004
EX-10.1 Amendment to Employment Agreement
Employment Agreements
Opko Health, Inc.
2003
EX-10.2 Amendment to Employment Agreement
Employment Agreements
Opko Health, Inc.
2003