Amendment Number 1 to License Agreement Regents of The University ofMichigan & Cancer Stem Cell Genomics, Inc. University of Michigan Files 1819, 1876, 1980, 2237, 2629, 2705

Exhibit 10.4(B)

Execution Version

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Amendment Number 1 to License Agreement

Regents of The University of Michigan &

Cancer Stem Cell Genomics, Inc.

University of Michigan Files 1819, 1876, 1980, 2237, 2629, 2705

Effective as of this 21st day of July, 2004, and in consideration of the mutual covenants contained herein, Cancer Stem Cell Genomics, Inc., a corporation incorporated in the State of Michigan, with offices located at 1385 Burgundy Road, Ann Arbor, MI 48105-2524 (“LICENSEE”), and the Regents of The University of Michigan, a constitutional corporation of the State of Michigan (“MICHIGAN”), agree to and hereby do amend their License Agreement, dated January 5, 2001 (hereinafter “Subject License”) in accordance with the following terms and conditions:

“Licensed Field” means cancer cells and non-cancer cells, including but not limited to (1) identification, purification, and assays thereof; (2) identification, purification, and assays of markers and agents, or molecules, that affect the function of cancer cells as compared to other cells; and (3) information and data related to gene expression, drug discovery, diagnostics and therapeutics related thereof.

“LICENSEE agrees to use its commercially reasonable efforts: (i) to develop Products and Processes, obtain any government approvals necessary, and manufacture and sell Products or Processes at the earliest practical date; and (ii) to effectively exploit, market and manufacture in sufficient quantities to meet anticipated customer demand and to make the benefits of the Products and Processes reasonably available to the public.”

“10.1 LICENSEE and MICHIGAN shall cooperate fully to obtain, protect and defend patent rights arising out of: (i) the Licensed Patents and (ii) if LICENSEE exercises its options under Sections 8.2 or 8.3 of the Research Agreement, the University Intellectual Property and Joint Intellectual Property, as each are defined in the Research Agreement, and will endeavor to develop a common strategy in order to do so. As used in this Article 10, “Licensed Patents” shall include the intellectual property described in Subsection (ii) above. Subject to the limitations described in this Article 10, LICENSEE, with full consideration for any obligations that MICHIGAN may have to third parties such as the US Government, shall have the right, through counsel of its choice and at its expense, to prepare the initial draft of all patent applications worldwide (including provisionals, non provisionals, continuations, divisions, continuations in part, PCT applications, national phase applications, reissues and reexaminations) for the Licensed Patents to assist MICHIGAN in the prosecution thereof before the US PTO and patent offices worldwide. Such drafts shall be reviewed and filed by MICHIGAN counsel. MICHIGAN shall receive correspondence from patent offices worldwide, and shall make available to LICENSEE all such documents as soon as feasible after receipt. LICENSEE and MICHIGAN will negotiate in good faith the terms of handling and control over any U.S interference that might be declared with respect to LICENSED PATENTS.

10.2 MICHIGAN may in its sole discretion decide to refrain from or to cease prosecuting or maintaining any of the Licensed Patents, including any foreign filing or any Patent Cooperation Treaty filing. If MICHIGAN makes any such decision,

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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MICHIGAN shall notify LICENSEE promptly and in sufficient time to permit LICENSEE at its sole discretion to continue such prosecution or maintenance at LICENSEE’s expense. If LICENSEE elects to continue such prosecution or maintenance, MICHIGAN shall execute such documents and perform such acts at LICENSEE’s expense as may be reasonably necessary for LICENSEE to so continue such prosecution or maintenance.

10.3 MICHIGAN shall make available to LICENSEE (or vice versa in instances where LICENSEE provides first drafts pursuant to Section 10.1) all draft filings and applications as well as all responses to be filed in response to any prosecution action within an amount of time reasonably sufficient (but in most cases, not less than three weeks) before filing, for review and comment by LICENSEE and/or counsel of its choice. LICENSEE and MICHIGAN shall cooperate with each other in the transmission of, and comment on, such documentation and shall instruct its respective counsel to do so.

10.4 In the case where MICHIGAN and LICENSEE disagree on a course of action or on a response or strategic position before a patent office, a senior individual of each party who has responsibility for patent and licensing activities at such party, with advice of their respective patent counsel, if necessary, will meet in person or by phone in a reasoned good faith effort to resolve the disagreement. If such disagreement is not resolved after discussion, MICHIGAN shall have the final decision on the matter.

10.5 If the parties cannot resolve between themselves matters of inventorship for new applications that are not on file and that do not claim priority to LICENSED PATENTS pending at the time of this Amendment then resolution of such dispute shall be subject to confidential mediation under the CPR Mediation Procedure, such mediation to be conducted in good faith in Chicago, Illinois, before resorting to arbitration. The cost of such mediation shall be shared equally by the parties. If such dispute cannot be resolved by mediation, then within seven (7) calendar days notice by either party, the resolution of such dispute shall be submitted to arbitration in accordance with the CPR Institute For Dispute Resolution (“CPR”) Rules for Non-Administered Arbitration of Patent and Trade Secret Disputes or Rules for Non-Administered Arbitration, as appropriate, in effect on the date of the dispute by a sole arbitrator who shall be appointed in accordance with the applicable CPR rules and whose ruling shall be binding and not subject to appeal (“CPR Arbitration”). Any other choice of law clause to the contrary in this Agreement notwithstanding, the arbitration shall be governed by the United States Arbitration Act, 9 U.S.C. Section 1-16. The costs of arbitration shall be borne solely by the party who did not prevail in the arbitration, as determined by the arbitrator.

10.6 LICENSEE shall reimburse all reasonable and necessary expenses paid by MICHIGAN in reviewing, monitoring and drafting with respect to the prosecution and maintenance of the Licensed Patents, including without limitation fees paid to outside counsel or consultants, and reasonable travel expenses incurred by MICHIGAN employees for the purpose of prosecution and maintenance of the Licensed Patents, but not including any part of any MICHIGAN employee’s salary, within thirty (30) days of invoice therefor if such invoice is accompanied by reasonable evidence of MICHIGAN’s

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expenses. Prior to the prosecution of any patent and on a case by case basis, LICENSEE and MICHIGAN shall use their best commercial judgment to budget a fixed amount of money for such reimbursement. MICHIGAN will not require LICENSEE to reimburse expenses incurred through foreign filings or Patent Cooperation Treaty filings initiated after the Effective Date, unless LICENSEE has authorized such filings. In any case where LICENSEE fails to reimburse MICHIGAN within thirty (30) days after receiving an invoice for reimbursement of any above-described expenses (whether or not related to filings requested by LICENSEE), any patent applications or resulting patents to which such unreimbursed expenses relate shall be excluded from the definitions of “TECHNOLOGY” and “Licensed Patents”; provided, however, that no such exclusion shall take place if LICENSEE has a good faith dispute related to any such invoice and notifies MICHIGAN in writing during such thirty (30) day period of such dispute. When invoice disputes cannot be resolved by mutual agreement of the parties within ten (10) days after a notice of dispute, the dispute shall be submitted to arbitration solely to determine the appropriate amount of fees to be reimbursed as set forth in this Section 10.6. The dispute shall be subject to CPR Arbitration with respect to the sole determination of what amount shall be reimbursed hereunder, if any.”

“15. ASSIGNMENT. The Agreement may not be assigned or otherwise transferred, nor, except as expressly provided hereunder, may any right or obligations hereunder be assigned or transferred by either party without the prior written consent of the other party; provided, however, that LICENSEE may, without such consent, assign the Agreement and its rights and obligations hereunder in connection with the transfer or sale of all or substantially all of its business, or in the event of its merger or consolidation or change in control or similar transaction. Any permitted assignee shall provide written notice to MICHIGAN and shall assume all obligations of its assignor under the Agreement and shall abide by all terms of this Agreement.”

(i) Section 30.4 of the Subject License shall be deleted in its entirety and replaced with the following:

(ii) Without limiting the generality of the definition of “Licensed Patent(s)” as set forth in Section 30.4 of the Subject License, as amended by Section 11 (i) of this

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Amendment, the parties agree that, as of the effective date of this Amendment, the Licensed Patents comprise the list of patent applications set forth on Attachment B hereto.

“As provided in Paragraph 8.5 of the License Agreement between MICHIGAN and Cancer Stem Cell Genomics, Inc., in the event of a termination of said License Agreement,”

“Article 31. In the event of disputes between or among the Parties arising out of or in connection with this Agreement, such disputes shall be resolved by good faith discussions by and among the senior individuals with responsibility for patent and licensing activities at the disputing Parties’ institutions, with advice of counsel, if necessary. Where disputes cannot be resolved by mutual agreement within sixty days, the disputing Parties agree to submit to binding

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arbitration upon written notice of one of the Parties. The arbitration shall be administered by the American Arbitration Association in accordance with the provisions of its Commercial Arbitration rules, and/or its Patent Arbitration rules, whichever is reasonably applicable, and Federal Arbitration Act. The written notice must contain a statement of the dispute in sufficiently clear detail for the arbitrators and the other party to understand it.

The arbitration proceedings shall be conducted before a panel of three neutral arbitrators. Within thirty (30) days after the notice of arbitration, each party shall select one person to act as arbitrator; and the two selected shall select the third arbitrator for the panel within thirty (30) days of the appointment of the last to be appointed of the initial two. The third arbitrator shall be chairperson of the arbitration panel. If the arbitrators selected by the parties are unable or fail to agree upon the third arbitrator by sixty (60) days after the notice of arbitration, the third arbitrator shall be selected by the American Arbitration Association. All members of the arbitration panel shall be paid the same rate. None of the panel members shall be employed by or affiliated in any way with either party (including, for example, as an independent consultant or as a customer or vendor to either party, or an employee of a customer or vendor).

The place of arbitration shall be in Chicago, Illinois. The Federal Rules of Civil Procedure shall apply where the rules of the American Arbitration Association are silent. The Parties shall allow and participate in discovery in accordance with the Federal Rules of Civil Procedure. Unresolved discovery disputes may be brought to the attention of the chair of the arbitration panel and may be disposed of by the chair of the panel.

The decision of the arbitrators must be in writing and must generally specify the basis on which the decision was made. Judgment on the award rendered by the arbitrators may be entered in any court having competent jurisdiction thereof. Each party shall bear its own costs and expenses and an equal share of the arbitrator’s and administrative fees of the arbitration.”

All other terms and provisions of the Subject License shall remain unaltered and in full effect. IN WITNESS WHEREOF, the Parties hereto have executed this Agreement by their duly authorized officers or representatives.

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Attachment A - Patent Expenses Billed to Michigan Through Date of Amendment

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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Attachment B

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