Second Amendment to Lease Agreement, dated March 25, 2024, by and between ARE-San Francisco No. 19 Owner, LLC and the Registrant

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of March 25, 2024 (“Effective Date”), by and between ARE-SAN FRANCISCO NO. 19 OWNER, LLC, a Delaware limited liability company (“Landlord”), and NURIX THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

A.    Landlord and Tenant entered into that certain Lease Agreement dated as of July 8, 2021 (the “Original Lease”), as amended by that certain First Amendment to Lease dated as of June 28, 2023 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises commonly known as Suite 493 and consisting of approximately 19,320 rentable square feet (the “Premises”) in a building located at 455 Mission Bay Boulevard South, San Francisco, California. The Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease.

B.    The Term of the Lease is scheduled to expire on June 30, 2024.

C.     Landlord and Tenant desire, subject to the terms and conditions set forth below, to among other things, extend the Term of the Lease through April 30, 2025 (the “Extended Expiration Date”).

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows:

1.Extended Term. The expiration date of the Term of the Lease is hereby extended until the Extended Expiration Date. Tenant shall continue to accept the Premises in its then-current “as-is” condition as of July 1, 2024, and Landlord shall have no obligation to perform any improvements or to provide any allowances for improvements during the Term as extended pursuant to this Section 1.

2.Base Rent; Additional Rent. Tenant shall continue to pay Base Rent for the Premises as provided in the Lease through June 30, 2024. Commencing on July 1, 2024 and continuing through the Extended Expiration Date, Tenant shall continue to pay Base Rent at the rental rate in effect as of June 30, 2024, which shall be calculated in accordance with Section 4 of the Original Lease. In addition, throughout the Extended Expiration Date, Tenant shall continue to pay Additional Rent in accordance with the terms and conditions of the Lease.

3.Parking. Throughout the Extended Expiration Date, Tenant’s parking rights shall continue as set forth in Section 10 of the Original Lease and the Parking Charges payable by Tenant shall continue to increase on each Parking Charge Adjustment Date by 3% as set forth in such Section 10.

4.Security Deposit. Landlord holds a Security Deposit in the amount of $115,920.00 in the form of a Letter of Credit. Concurrent with Tenant’s delivery of copy of this Second Amendment executed by Tenant, Tenant shall deliver to Landlord an amendment to the Letter of Credit extending the expiration date of the Letter of Credit until 90 days after the Extended Expiration Date.

5.Right to Extend Term. Tenant shall continue to have the Extension Right pursuant to Section 39 of the Original Lease, except that, following the execution of this Second Amendment, the term of any such extension will be limited to two (2) years, unless otherwise mutually agreed upon by Landlord and Tenant.

6.Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Second Amendment and that no Broker brought about this transaction, other than CBRE, Inc.

Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other than CBRE, Inc., claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Second Amendment.

7.Section 1938 Disclosures.  Section 41(p) of the Original Lease is incorporated herein as though set forth in full herein.

8.OFAC. Tenant and all beneficial owners of Tenant are currently (a) in compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List, or the Sectoral Sanctions Identification List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules.

9.Miscellaneous.

IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the Effective Date above written.