Circumventing nausea and vomiting. According to a survey of over 500 respondents conducted by the National Headache Foundation in 2008, 90% of migraineurs have experienced nausea with a migraine and 59% of migraineurs have experienced vomiting with a migraine. In this survey, 48% of respondents who ever experienced nausea or vomiting with a migraine reported that the nausea or vomiting had a moderate to major impact on when or how they take migraine medications. The American Academy of Neurology guidelines recommend non-oral therapies for migraineurs who experience nausea or vomiting as significant migraine symptoms. Because Zelrix is administered transdermally, we believe

EX-10.18 22 w78367a1exv10w18.htm EX-10.18 exv10w18
Exhibit 10.18
Indemnification Agreements
The following current directors of NuPathe Inc. are each a party to an Indemnification Agreement with NuPathe Inc. consistent in all material respects with the Form of Indemnification Agreement which is filed as Exhibit 10.17 to Amendment No. 1 to NuPathe Inc.’s Registration Statement on Form S-1 filed June 15, 2010.
Michael Cola
Jeanne Cunicelli
Michael C. Diem, MD
John H. Dillon, II
Jane H. Hollingsworth
Richard S. Kollender
Gary J. Kurtzman, MD