Fourth Amendment to the Development and License Agreement between the Registrant and Amgen Inc. dated August 10, 2011
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EX-10.5 17 exhibit10-5.pdf THIRD AMENDMENT TO THE DEVELOPMENT AND LICENSE AGREEMENT BETWEEN THE REGISTRANT AND AMGEN INC. begin 644 exhibit10-5.pdf M)5!$1BTQ+C0-)>+CS],-"C$Y,"`P(&]B:@T\/"],:6YE87)I>F5D(#$O3"`T M,#`U,"]/(#$Y,R]%(#(Q-3(V+TX@,R]4(#,V,C`R+T@@6R`X-3$@,CF4@,C$W+U!R978@,S8Q.3`O6%)E9E-T;2`Q,3(Q+U)O;W0@ M,3DQ(#`@4B]);F9O(#$U(#`@4B])1%L\,D)$13DW,$4T1#,V,D4V-D,Q,C1" M0S4X,#,P.#8W1#4^/#`X0D,U-T(Y0C4Y0T5%-$8Y13A"-#5%0S)&1C=$1C!G M0`!^!A:@*`L#QXJ&_C8##@:&1D`$NOH8&!@ M%#8%40P<'1`-0,#.p)`m!*3%@5@2+*+*p,>4()P0=TB:L8&!P?C`5>873!/F M-YWCJM$16,ZDP;5%=M&,)%[F`*X&)D83I@RHE=P,#!47&<".9;`%8dx&aepm m")][.9*3&;ie@30c$!d#!!@`"g4@7pt*96yd%LQ-B`Q-S1=+T1E8V]D95!AF4@,3DP+U1Y<&4o6%)e9cx^7!E+T-A=&%L;V'1=+U!R;W!E7!E+U!A9V4^/@UE;F1O8FH-,3DT(#`@;V)J M#3P\+U-U8G1Y<&4o5')u951y<&4o1f]n=$1e%LM-34X("TS,#<@,c`p m,"`q,#(v72]!7!E+T9O;G1$97-C5%"[;L,P#-SU M%1Q;9)#B=#0,%,GBH0_43G=%HAT!,270\N"_KR0X"3J0!(\\W)'RV)Y:RF70`F<6ah\u+60/vdx1u[a mi>\/._4*\HLMLJ,Q(6_5^3D"`J:!BP.0AX_=/C4$X(LQ"?8KP&A M*OU^T_86YZ`-LJ81H59*'9I[0;+_YW?693!7S>*Y_:X:D;8W///R30\?9F%. 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